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Drug substance refers to the drug substance used in the production of various preparations. It is the effective ingredient in the preparations. It is the powder, crystal, extract, etc. prepared by chemical synthesis, plant extraction or biotechnology and used as medicine, but cannot be taken directly by patients.The perfect definition of API in ICH Q7A: any substance or mixture of substances intended to be used in the manufacture of drugs and become an active ingredient of drugs when used in pharmaceuticals. This substance has pharmacological activity or other direct effects in the diagnosis, treatment, symptom relief, treatment or disease prevention of diseases, or can affect the function or structure of the body.

To thoroughly review the uses of human chorionic gonadotropin (hCG) related to the process of reproduction and also assess new, non-traditional theories. Review of the international literature and research studies. hCG and its receptor, LH/CGR, are expressed in numerous sites of the reproductive tract, both in gonadal and extra-goanadal tissues, promoting oocyte maturation, fertilization, implantation and early embryo development. Moreover, hCG seems to have a potential role as an anti-rejection agent in solid organ transplantation. Future research needs to focus extensively on the functions of hCG and its receptor LH/CGR, in an effort to reveal known, as well as unknown clinical potentials.Keywords: hCG, LH/CGR, ovulation induction, oocyte maturation, endometrial synchrony, immunization

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