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No. The HCG diet isn't safe, and it doesn't lead to long-term weight loss. HCG stands for human chorionic gonadotropin. It's a hormone made in the body during pregnancy. Lab-made HCG is added to some weight-loss products that are sold without a prescription. The U.S. Food and Drug Administration (FDA) warns against using these products. The HCG diet combines these weight-loss products with a very low-calorie eating plan.

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This document presents current approaches and concerns regarding over-the-counter hCG devices. It is based on: 1) current science; 2) clinical experience; 3) previous submissions by manufacturers to the Food and Drug Administration (FDA); 4) the FDA Modernization Act of 1997 (FDAMA); and 5) FDA regulations in the Code of Federal Regulations (CFR). As advances are made in science and technology, and as changes in implementation of legislation occur, these Review Criteria will be re-evaluated and revised as appropriate. So that the draft may be revised as necessary, please send comments as instructed in the Preface.

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The Food and Drug Administration (FDA) has approved hCG injections to treat specific medical conditions. In females assigned at birth (FAABs), they can help treat infertility. In males assigned at birth (MAABs), they can treat a type of hypogonadism.Human chorionic gonadotropin (hCG) is sometimes called “the pregnancy hormone” because of its important role in maintaining pregnancy.Pregnancy tests check hCG levels in the urine or blood to determine if a person is pregnant or not. 

Photo showing a urine sample that has tested positive for human chorionic gonadotropin (hCG). This hormone is secreted by the placenta in pregnant women.Human chorionic gonadotrophin (hCG) is a hormone produced by the cells that surround the growing human embryo that go on to form the placenta (called trophoblasts). Human chorionic gonadotrophin can be detected in the urine from 7-9 days after fertilisation as the embryo attaches and implants in the womb; it forms the basis of most over-the-counter and hospital pregnancy tests (see photo).