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The Food and Drug Administration (FDA) has approved hCG injections to treat specific medical conditions. In females assigned at birth (FAABs), they can help treat infertility. In males assigned at birth (MAABs), they can treat a type of hypogonadism.Human chorionic gonadotropin (hCG) is sometimes called “the pregnancy hormone” because of its important role in maintaining pregnancy.Pregnancy tests check hCG levels in the urine or blood to determine if a person is pregnant or not. 

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To thoroughly review the uses of human chorionic gonadotropin (hCG) related to the process of reproduction and also assess new, non-traditional theories. Review of the international literature and research studies. hCG and its receptor, LH/CGR, are expressed in numerous sites of the reproductive tract, both in gonadal and extra-goanadal tissues, promoting oocyte maturation, fertilization, implantation and early embryo development. Moreover, hCG seems to have a potential role as an anti-rejection agent in solid organ transplantation. Future research needs to focus extensively on the functions of hCG and its receptor LH/CGR, in an effort to reveal known, as well as unknown clinical potentials.Keywords: hCG, LH/CGR, ovulation induction, oocyte maturation, endometrial synchrony, immunization