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Mar . 24, 2023 22:31 Back to list

What is the meaning of pharmaceutical intermediates



The meaning of pharmaceutical intermediates is that two or more different substances have special properties of products through systematic chemical reactions in appropriate proportions. It retains the unique efficacy of its own raw materials, overcomes the defect of using a single raw material, and improves the efficacy and safety of the drug.

Pharmaceutical intermediates are a new synthetic method, which have been widely used in many important fine chemical products at home and abroad, such as pesticides, dyes, spices, etc. Pharmaceutical intermediates are also called pharmaceutical intermediates. It belongs to the category of fine chemicals and pharmaceutical intermediates. It refers to the synthetic derivatives of two or more organic compounds through chemical methods or artificial synthesis, or a naturally occurring, but human beings have not mastered the chemical synthesis of organic compounds. Pharmaceutical intermediates are fine chemical products, such as herbicides, pesticides, detergents, spices, drugs, etc. General pharmaceutical intermediates are more expensive.

Definition: 1. Pharmaceutical intermediates Pharmaceutical intermediates refer to compounds with similar but different chemical structures, also known as new materials. Pharmaceutical intermediates mainly refer to similar chemical structural formula, but there is another difference between ethyl acetate and n-butyl propionate, methyl methacrylate and methyl acrylate. Therefore, pharmaceutical intermediates are made by using chemical synthesis methods with similar chemical structures, some have good chemical stability, some can be dissolved in polar solvents, some still have the advantages of low toxicity and easy to use, and are made by different methods

  1. Pharmaceutical intermediates can be classified according to their sources and uses, as shown below. (1) It is extracted from natural products through chemical modification of derivatives. These derivative molecules are the original compounds in the homologues of parent compounds, such as: ethyl acetoacetate is diethyl malonate; Amino acid methyl ester is resorcinol methanolate. (2) Chemical synthesis. Including direct synthesis and indirect synthesis. The synthesis reaction is simple, the reactants are synthesized, and the yield is high. A typical example is the esterification of dimethyl malonate and ethyl phenylacetate by ethyl phenylacetate and diethyl malonate through lactic acid. For example, isooctyl phenylacetate and ethyl malonate can be obtained by direct exchange of ethylphenylacetic acid and diethyl malonate.
  2. The production of pharmaceutical intermediates is a new synthetic method, which has been widely used in many important fine chemical products at home and abroad, such as pesticides, dyes, spices, etc. Pharmaceutical intermediates are also known as pharmaceutical intermediates.

The production of pharmaceutical intermediates consists of two steps: synthesis and purification. The first step is to go through the synthesis process. The synthetic products are refined to reach purity, and finally sold as commodities.

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