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  • I-DSIP CAS 62568-57-4

Jun . 30, 2023 09:36 Buyela kuluhlu

I-DSIP CAS 62568-57-4



  • I-DSIP CAS 62568-57-4 WHATSAPP:+86-19031013676

  • I-Emiditide yi-neuropeptide ene-antioxidant kunye ne-anti-anxiety effects

  • 1. Ku vivo funda
  • I-Inrabbitin idityaniswe nge-δ-InducingInducingPeptide(DSIP), umsebenzi wokujikeleza uyanyuka, kunye nentliziyo kunye nokuphefumla kwehle kancinci.δ-SleepInducingPeptide(DSIP)mayactasaprogrammingmodulatoratsupra-operationallevelratherthanasatransmitteratoperaptileveldeepI-DSμincwadiI-DSμindlela yokuqhuba; ,ip)yandisa i-scatalasekunye ne-superoxidedismutase(SOD)imisebenzi kunye nemalonicdialdehyde(MDA)uxinanisokwiliverhomogenateofratsluphantsi kwecutestress,kodwa iziphumo ezichaseneyo zijongwe kwi-120,kunye ne-360μg/kg.
  • Iipropathi ze-emidi Indawo yokubilisa 1522.7±65.0°C(Kuqikelelwe) Ubuninzi 1.458±0.06g/cm3(Kuqikelelwe) Iimeko zokugcina −20°C iMilo yePowder i-Acidity coefficient (Kuqikelelwe) 3.18±0.10(Kuqikelelwe) Ukunyibilika kwamanzi Isisombululo kunye neSolubleinwaterat0.5 mg/mlInChIKeyZRZROXNBKJAOKB - GFVHOAGBSA - N

  • 2. ukunyibilika

    3. Kwi-Vitro:

    H2O.

     

    4. Unyibiliko lwePeptide kunye nezikhokelo zokugcina:

     

    1. Bala ubude bepeptide.

     

    2. Bala intlawulo iyonke yepeptide yonke ngokwale theyibhile ilandelayo:

     

    Ixabiso lesabelo somxholo I-Acidic amino acids i-Asp (D), i-Glu (E) kunye ne-C-terminal -COOH. -1 Basic amino acids Arg (R), Lys (K), Yakhe (H) kunye N-terminal -NH 2+1 neutral amino acids Gly (G), Ala (A), Leu (L), Ile (I) , Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), ITyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

    3. Izisombululo ezicetyiswayo:

     

    Itotali yeenkcukacha zentlawulo yepeptide ayinayo (<0) 1. Kuqala zama ukunyibilikisa i-peptide emanzini. 2. Ukuba amanzi akaphumeleli, yongeza i-NH 4 OH (<50μL). 3. Ukuba i-peptide ayikanyibiliki, yongeza i-DMSO (50-100μL) ukunyibilikisa i-peptide. Okuhle (> 0) 1. Qala uzame ukunyibilikisa i-peptide emanzini. 2. Ukuba amanzi akaphumeleli, zama ukutshabalalisa i-peptide kwisisombululo se-10% -30% ye-acetic acid. 3. Ukuba i-peptide ayikanyibiliki, zama ukunyibilikisa i-peptide ngexabiso elincinci le-DMSO. 0 (= 0) 1. Okokuqala zama ukunyibilikisa i-peptide kwi-solvents eziphilayo (i-acetonitrile, i-methanol, njl.). 2. Kwi-peptides ye-hydrophobic kakhulu, zama ukunyibilikisa i-peptide kwixabiso elincinci le-DMSO kwaye emva koko uhlambulule isisombululo ngamanzi kwi-concentration oyifunayo.

Yabelana
Okulandelayo:

Iindaba zamva
Asset 3

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