I-Semax cas 80714-61-0 ngexabiso lentengiso

I-MEHFPGP yi-peptide ye-neuroprotective. I-MEHFPGP ingasetyenziselwa uphando lwe-stroke

I-MEHFPGP (i-25μM kunye ne-100μM, i-48 h) yanciphisa i-Abeta oligomers (100μM) amanqanaba [2]. I-MEHFPGP (100nM) yonyusa ukusinda kwe-cholinergic basal forebrain neurons [3]. I-MEHFPGP (i-100 nM) ivuselele umsebenzi we-choline acetyltransferase kwi-free basal forebrain tissue culture [3]. I-MEHFPGP (i-10μM, i-24 h) ivuselele ukuhlanganiswa kwe-brain-derived neurotrophic factor (BDNF) kwi-astrocytes ekhuliswe kwi-basal forebrain yeempuku.

I-MEHFPGP (i-Semax, i-100μg / kg, ip) ikhuthaza ukubunjwa kunye nokusebenza kwenkqubo ye-vascular ngexesha le-ischemia (pMCAO) kwiigundane [1]. I-MEHFPGP (i-50µg kunye ne-250µg, i-100µL / kg, i-intranasal inhalation) inyuse izinga leprotheni ye-BDNF kwi-basal forebrain yeegundane [5]. Imodeli yezilwanyana: Ischemic (pMCAO) ibuzi [1]. I-Dose: 100μg / kg Ulawulo: I-injection ye-Intraperitoneal (ip) imizuzu ye-15, i-1, i-4, kunye neeyure ze-8 emva kwesigxina esisisigxina se-cerebral artery occlusion (pMCAO). Iziphumo: Impendulo yokuzivikela komzimba yongezwa (umbhalo wawulawulwa). Imodeli yezilwanyana: ibuzi [5] Idosi: 50µg, 250µg, 100µL/kg Ulawulo: Ukuphefumla ngeempumlo

Iimpawu zomzimba kunye neekhemikhali zeSemax

Uxinaniso 1.391g/cm3

Indawo yokubilisa 1335.2ºC ku-760 mmHg

Ifomula yemolekyuli C37H51N9O10S

Ubunzima bemolekyuli 813.92000

Indawo edanyazayo 761.3ºC

Ubunzima obuchanekileyo 813.34800

PSA 325.58000

IlogP 2.71460

Refractive index 1.617

Inkcazo yamanyathelo oncedo lokuqala ayimfuneko

1.1 ukufunxa

Ukuba utsaliwe, susa isigulane emoyeni omtsha. Ukuba uyeka ukuphefumla, nika umoya owenziweyo.

Uqhagamshelwano lwesikhumba

Pula ngesepha kunye namanzi amaninzi.

Uqhagamshelo lamehlo

Hlamba amehlo akho ngamanzi njengenyathelo lokhuseleko.

ukungeniswa

Musa ukondla nantoni na esuka emlonyeni emntwini ongekho zingqondweni. Hlamba umlomo wakho ngamanzi.

1.2 Iimpawu eziphambili kunye neziphumo, iziphumo ezibukhali kunye nezasemva kwexesha

Ngokolwazi lwethu, le mveliso yekhemikhali, ebonakalayo kunye netyhefu ayizange ifundwe ngokupheleleyo

I-Semax cas 80714-61-0 ngexabiso lentengiso

I-MEHFPGP yi-peptide ye-neuroprotective. I-MEHFPGP ingasetyenziselwa uphando lwe-stroke

I-MEHFPGP (i-25μM kunye ne-100μM, i-48 h) yanciphisa i-Abeta oligomers (100μM) amanqanaba [2]. I-MEHFPGP (100nM) yonyusa ukusinda kwe-cholinergic basal forebrain neurons [3]. I-MEHFPGP (i-100 nM) ivuselele umsebenzi we-choline acetyltransferase kwi-free basal forebrain tissue culture [3]. I-MEHFPGP (i-10μM, i-24 h) ivuselele ukuhlanganiswa kwe-brain-derived neurotrophic factor (BDNF) kwi-astrocytes ekhuliswe kwi-basal forebrain yeempuku.

I-MEHFPGP (i-Semax, i-100μg / kg, ip) ikhuthaza ukubunjwa kunye nokusebenza kwenkqubo ye-vascular ngexesha le-ischemia (pMCAO) kwiigundane [1]. I-MEHFPGP (i-50µg kunye ne-250µg, i-100µL / kg, i-intranasal inhalation) inyuse izinga leprotheni ye-BDNF kwi-basal forebrain yeegundane [5]. Imodeli yezilwanyana: Ischemic (pMCAO) ibuzi [1]. I-Dose: 100μg / kg Ulawulo: I-injection ye-Intraperitoneal (ip) imizuzu ye-15, i-1, i-4, kunye neeyure ze-8 emva kwesigxina esisisigxina se-cerebral artery occlusion (pMCAO). Iziphumo: Impendulo yokuzivikela komzimba yongezwa (umbhalo wawulawulwa). Imodeli yezilwanyana: ibuzi [5] Idosi: 50µg, 250µg, 100µL/kg Ulawulo: Ukuphefumla ngeempumlo

Iimpawu zomzimba kunye neekhemikhali zeSemax

Uxinaniso 1.391g/cm3

Indawo yokubilisa 1335.2ºC ku-760 mmHg

Ifomula yemolekyuli C37H51N9O10S

Ubunzima bemolekyuli 813.92000

Indawo edanyazayo 761.3ºC

Ubunzima obuchanekileyo 813.34800

PSA 325.58000

IlogP 2.71460

Refractive index 1.617

Inkcazo yamanyathelo oncedo lokuqala ayimfuneko

1.1 ukufunxa

Ukuba utsaliwe, susa isigulane emoyeni omtsha. Ukuba uyeka ukuphefumla, nika umoya owenziweyo.

Uqhagamshelwano lwesikhumba

Pula ngesepha kunye namanzi amaninzi.

Uqhagamshelo lamehlo

Hlamba amehlo akho ngamanzi njengenyathelo lokhuseleko.

ukungeniswa

Musa ukondla nantoni na esuka emlonyeni emntwini ongekho zingqondweni. Hlamba umlomo wakho ngamanzi.

1.2 Iimpawu eziphambili kunye neziphumo, iziphumo ezibukhali kunye nezasemva kwexesha

Ngokolwazi lwethu, le mveliso yekhemikhali, ebonakalayo kunye netyhefu ayizange ifundwe ngokupheleleyo