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  • Kisspeptin 10 (muntu) cas 374675-21-5

Jul. 07, 2023 09:22 Subira kurutonde

Kisspeptin 10 (muntu) cas 374675-21-5



Kisspeptin 10 (muntu) cas 374675-21-5

Kisspeptin-10, umuntu, ni vasoconstrictor ikomeye na angiogenez inhibitor. Kisspeptin-10, muntu, ibuza metastasis ikibyimba ikoresheje reseptor yayo GPR54. Sisitemu ya Kisspeptin-10-GPR54 igira uruhare runini mu mikurire y'impyiko. Kisspeptin-10 / GPR54 yerekana itera osteoblast itandukanya binyuze muri NFATc4 ihuza imvugo ya BMP2

Kisspeptin-10 Ubucucike bwumutungo 1.46 ± 0.1g / cm3 (Biteganijwe) Imiterere yububiko -20 ° C Gukemura DMF: 15mg / ml; DMSO: 15mg / ml; DMSO: PBS (pH7.Igitabo cya 2) (1: 2): 0.33mg / ml formacrystallinesolid Coefficient (pKa) 9.96 ± 0.15

mu bushakashatsi bwa vitro

Kisspeptin-10 (KP-10) yongereye cyane guhuza ingirabuzimafatizo za THP-1 kuri HUVEC inshuro 10 kuri 10μM. Kwitegura hamwe na GPR54 antagonist P234 (20μM) yabujije cyane Kisspeptin-10 (10μM) -yatewe na THP-1 ingirabuzimafatizo ya HUVEC. Ibisubizo byerekana ko Kisspeptin-10 yongerera guhuza selile THP-1 kuri HUVEC ikoresheje GPR54. Kisspeptin-10 yazamuye cyane mRNA imvugo ya TNF-α, IL-6, MCP-1, ICAM-1, VCAM-1, na poroteyine e-ihitamo muri HUVEC. Kisspeptin-10 yiyongereye cyane kuri poroteyine ya ICAM-1 na VCAM-1 muri HUVECs, ugereranije no kwiyongera kwa mRNA

muri vivo 

Kugirango dusuzume uruhare rwa Kisspeptin-10 (KP-10) na GPR54 antagonist P234 mugutezimbere ibikomere bya atherosklerotike muri ApoE ebyiri zitandukanye - / - imbeba (C57 / B6 na BALB / c). Muri ApoE - / - imbeba (C57 / B6), ubuso (bwose) hamwe nubuso bwambukiranya imizi (ingano ya plaque) ya aortic atherosclerotic ibikomere hamwe na pentamer-3-nziza, kwinjirira monocyte / macrophage nibirimo VSMC byari bigaragara cyane yiyongereye ku byumweru 17 by'amavuko ugereranije n'ibyumweru 13 by'amavuko. Mugihe cibyumweru 17 byamavuko, plasma Kisspeptin-10 yibanze cyane mumbeba zatewe hamwe na Kisspeptin-10 (12.5μg / kg / saha) ugereranije no kugenzura abatwara. Umubare munini wa Kisspeptin-10 (12.5μg / kg / saha) wongereye cyane uduce twa atherosclerotic lesion ya aorta hamwe na plaque ya atherosclerotic, byongera cyane pentagramin-3 ahantu heza hamwe na monocyte / macrophage, kandi byagabanutse cyane kuri VSMC. Mu matsinda 3 ya ApoE - / - imbeba zifite ibyumweru 17, nta tandukaniro rikomeye ryagaragaye muburemere bwumubiri, gufata ibiryo, umuvuduko wamaraso wa systolique na diastolique, hamwe na plasma yibintu bya cholesterol cyangwa glucose. Gutera Kisspeptin-10 byagabanije umuvuduko w'amaraso ya microcasculaire yimbeba. Imihindagurikire ya metabolite yumutima mu mbeba zavuwe na Kisspeptin-10 zakozweho ubushakashatsi hakoreshejwe ubushakashatsi bwa metabolomics bushingiye kuri GC / TOF-MS mu mbeba. Kumenyekanisha inzira ya metabolike hamwe na biomarkers birashobora gufasha gusobanukirwa nuburyo Kisspeptin-10 ivura ihindura imikorere yumutima. Mitochondriya irimo metabolisme yingufu igaragazwa no kwanduza microscopi electronique (TEM), kandi ihindagurika ryingufu za metabolisme rishobora guterwa nimpinduka zimiterere ya mito-iyambere. Hariho itandukaniro rigaragara hagati yubugenzuzi (N) na Kisspeptin-10 (K) mumashusho yerekeranye na serumu sample.v

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