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  • I-MOG (35-55) CAS 149635-73-4 ngexabiso lentengo

Agasti . 03, 2023 09:27 Buyela kuluhlu

I-MOG (35-55) CAS 149635-73-4 ngexabiso lentengo



I-MOG (35-55) CAS 149635-73-4 ngexabiso lentengo

I-Myelin oligodendrocytes glycoprotein (myelinoligodendrocyteglyco - protein, MOG) yinkqubo ye-nervous central (centralnervoussystem, CNS) i-myelin engaphandle komxholo weprotheyini ye-myelin encinci, i-subtype ye-immunoglobulin IgG1, elawula ngokufanelekileyo i-complement-dependent ye-cytotoxicity engundoqo ye-cytotoxicity. -i-induced demyelination ye-MS. Ukumelana ne-MOG ye-antibody kwi-multiple sclerosis (i-multiplesclerosis, i-MS) idlala indima ebaluleke kakhulu kwinkqubo ye-pathological, eyenziwa yi-MOG yovavanyo lwe-autoimmune encephalomyelitis (i-experimentalautoimmuneencephalomyelitis, i-EAE ngumzekelo wezilwanyana owaziwayo ngamazwe we-MS.

Iimpawu 1. I-adhesion molekyuli ye-OG i-immunoglobuloin-like region ifana ne-butyrophilin yommandla ofanayo, kunye ne-antigen yenkukhu ye-BG ayikwazi ukuqaphela umsebenzi we-MOG. I-surface localization ye-MOGs, ukuqatshelwa kwe-MOGs njenge-immunoglobulin superfamily, kunye nokubonakala kwe-Lα / HNK-1 i-carbohydrate antigen epitopes zonke zixhasa umsebenzi we-MOG njengama-adhesion molecules okanye i-cell receptors. Ufumene kwi-alpha / HNK L - i-antigen epitope ye-1 ichongiwe njenge-myelin ehambelana ne-glycoprotein (i-myelin - ehambelana ne-glycoprotein, i-MAG) kunye ne-P0, zombini inecandelo lokubambelela kwi-protein ye-myelin. Ukuba i-MOG inomsebenzi wokubambelela, inokudibana namanye amacandelo e-nervous system ngaphandle kwayo; Kucingelwa ukuba ukuba i-MOG inendima ebalulekileyo kwi-cell adhesion, i-MOG inokusebenza njenge-adhesive "glue" phakathi kwe-myelin fibers ekufutshane kwaye yenzeke kamva kwinkqubo ye-myelination. 2. I-Microtubule i-stable regulator 8-18C5 i-antibody ingabangela ukuthotywa kwe-MBP kwi-sheath ye-myelin ecocekileyo. 3. Yenza i-complement complement MOG genes in major histocompatibility complex (MHC) majorhistocompatibilitChemicalbookycomplex, indawo efanayo nenkukhu ye-MHC antigen B - G, isakhiwo sayo sifana neentsapho zemfuza, inokubangela ukuphendula okunamandla omzimba. I-MOG icingelwa ukuba inomsebenzi wokuzivikela kwi-system ye-nervous system, kwaye iingxelo zamva nje zokuqala zibonisa ukuba i-MOG ibonakaliswe kuluhlu lwe-neutrophils, olukwaxhasa umsebenzi wokuzivikela we-MOG. Nangona i-MOG ingekho kwiintlobo ezingondliyo ze-myelin, inokuchazwa ngeendlela ezininzi. Enye inkcazo kukuba i-MOG ayenzi ngokuthe ngqo kwiinkqubo ze-myelin, kwaye ngokuchanekileyo, inokulamla i-myelin kunye nezinye iinkqubo kwi-vivo. Elinye icandelo, njengokunxibelelana phakathi kwamajoni omzimba; Enye inkcazo kukuba i-MOG ihambelana ngokuthe ngqo nomsebenzi wokuzivikela we-CNS myelin sheath, ngokungafaniyo ne-peripheral nervous system myelin sheath, eyenza i-classical complement pathway in vivo. Isitofu sokukhusela i-DNA ye-encoding ye-MOG (MOG) - i-DNA inokuthintela iigundane ngovavanyo lwe-autoimmune encephalomyelitis (i-EAE experimentalautoimmuneencephalomyelitis), ngendima yokuphunyezwa kwe-C3d. Ke ngoko, i-CNS myelin sheath kufuneka iqulathe amacandelo ahambelanayo abopha i-Ctq, ekhokelela ekusebenzeni okuhambelanayo.

 

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