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Jul . 05, 2023 15:15 Back to list

TRH cas 24305-27-9 at wholesale price



TRH cas 24305-27-9 at wholesale price

Protirelin (formerly thyrotropin-releasing hormone) is a tripeptide hormone released by the hypothalamus. It was first purified and synthesized from hypothalamic tissue of sheep and pigs in the late 1960s. TRH Chemicalbook is widely distributed in the central nervous system and some peripheral organs. In addition to endocrine effects, TRH also plays the role of endogenous excitatory neurotransmitter, which can produce a wide range of central and peripheral effects. It has certain antagonistic effect on endogenous opioid receptors, but it does not antagonize the analgesic effect of morphine, and prorelin was first reported to have anti-shock effect in 1981.

In addition to the treatment of shock, prorelin has other uses, such as the treatment of hypothalamic hypothyroidism, central hyperthyroidism in endocrinology. It is used in psychiatry to treat depression and schizophrenia. Neurology is used to treat brain and spinal cord injuries, coma of various causes, amyotrophic lateral sclerosis, spinocerebellar degeneration, senile dementia, epilepsy, etc. Diagnostic for the diagnosis of hyperthyroidism. Therefore, prorelin is a drug with good development value and deserves further study to expand its application.

Application 1. Treatment of shock; 2. Treatment of hypothalamic hypothyroidism and central hyperthyroidism in secretory department; 3. Psychiatric treatment of depression and schizophrenia; 4. Neurochemicalbook is used to treat brain and spinal cord injury, coma of various causes, amyotrophic lateral sclerosis, spinocerebellar degeneration, senile dementia, epilepsy, etc.; 5. Diagnosis for the diagnosis of hyperthyroidism.

Prorelin is a tripeptide hormone in the body, the chemical structure is relatively simple, has been synthetic, freeze-dried powder can be stored at room temperature for one year,4℃ storage for several years, the price is moderate. Pharmacological dose of prorelin has a clear anti-shock effect on a variety of circulatory shock, such as hemorrhagic, infectious, traumatic, spinal shock has a clear therapeutic effect, literature has reported that it also has an anti-shock effect on anaphylactic shock, platelet activator and leukotriene-induced hypotension, and its anti-shock effect is superior to common anti-shock drugs in many aspects. For example, compared with vasoconstricting drugs, the pressure increase is more moderate, and the pressure increase also improves the microcirculation. Compared with vasodilator drugs, it still has a good effect without the use of Chemicalbook solution without relying on full volume recovery. Compared with naloxone, it does not antagonize μ-opioid receptors, does not affect the use of morphine, and is especially suitable for traumatic shock. Moreover, prorelin has low toxicity, large therapeutic dose width, and no teratogenic, mutagenic and lethal effects. So prorelin may be a promising new class of antishock drugs. At present, trauma has become a major cause of death in humans after cardiovascular disease and tumor, and more than 30% of the deaths in trauma are from shock. Other causes of shock such as septic shock (mortality up to 30% to 50%), anaphylactic shock, hemorrhagic shock are also common. However, antishock drugs still have many shortcomings, so it is very important to develop new antishock drugs

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