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  • TRH cas 24305-27-9 ka theko e felletseng

Jul. 05, 2023 15:15 Khutlela lethathamong

TRH cas 24305-27-9 ka theko e felletseng



TRH cas 24305-27-9 ka theko e felletseng

Protirelin (eo pele e neng e le thyrotropin-releasing hormone) ke hormone ea tripeptide e hlahisoang ke hypothalamus. E ile ea hloekisoa ka lekhetlo la pele le ho etsoa ho tloha ho linku le likolobe tsa hypothalamic ho elella bofelong ba lilemo tsa bo-1960. TRH Chemicalbook e ajoa haholo tsamaisong ea methapo e bohareng le litho tse ling tsa peripheral. Ntle le litlamorao tsa endocrine, TRH e boetse e bapala karolo ea endogenous excitatory neurotransmitter, e ka hlahisang mefuta e mengata ea litlamorao tse bohareng le tsa peripheral. E na le phello e itseng ea bohanyetsi ho li-receptor tsa endogenous opioid, empa ha e hanyetse phello ea analgesic ea morphine, 'me prorelin e ile ea tlalehoa hore e na le phello ea anti-shock ka 1981.

Ntle le ho phekola ho tšoha, prorelin e na le lisebelisoa tse ling, tse kang phekolo ea hypothalamic hypothyroidism, hyperthyroidism e bohareng ho endocrinology. E sebelisoa ho tsa kelello ho phekola khatello ea maikutlo le schizophrenia. Neurology e sebelisetsoa ho phekola likotsi tsa boko le lesapo la mokokotlo, coma ea lisosa tse fapaneng, amyotrophic lateral sclerosis, spinocerebellar degeneration, senile dementia, sethoathoa, joalo-joalo. Tlhahlobo bakeng sa ho fumanoa ha hyperthyroidism. Ka hona, prorelin ke sethethefatsi se nang le boleng bo botle ba nts'etsopele mme se lokeloa ke boithuto bo eketsehileng ho atolosa ts'ebeliso ea sona.

Kopo ea 1. Kalafo ea ho tšoha; 2. Phekolo ea hypothalamic hypothyroidism le hyperthyroidism bohareng lefapheng la sephiri; 3. Phekolo ea kelello ea ho tepella maikutlong le schizophrenia; 4. Neurochemicalbook e sebelisetsoa ho phekola boko le mokokotlo oa mokokotlo, coma ea lisosa tse sa tšoaneng, amyotrophic lateral sclerosis, spinocerebellar degeneration, senile dementia, sethoathoa, joalo-joalo; 5. Tlhahlobo ea ho hlahlojoa ha hyperthyroidism.

Prorelin ke hormone ea tripeptide 'meleng, sebopeho sa lik'hemik'hale se batla se le bonolo, se entsoe, phofo e omisitsoeng ka leqhoa e ka bolokoa mocheso oa kamore bakeng sa selemo se le seng, 4 ℃ polokelo ka lilemo tse' maloa, theko e leka-lekane. Pharmacological dose ea prorelin e na le phello e hlakileng ea anti-shock ho mefuta e fapaneng ea ts'oaetso ea ho potoloha ha mali, e kang mali a mali, a tšoaetsanoang, a sithabetsang, a na le phello e hlakileng ea phekolo, lingoliloeng li tlalehile hore e boetse e na le phello e khahlanong le ho sisinyeha ha anaphylactic shock, platelet activator le leukotriene-induced hypotension, 'me phello ea eona ea anti-shock e phahametse lithethefatsi tse tloaelehileng tse khahlanong le ts'oaetso likarolong tse ngata. Ka mohlala, ha ho bapisoa le lithethefatsi tsa vasoconstricting, khatello ea kelello e eketseha, 'me khatello ea khatello e boetse e ntlafatsa microcirculation. Ha e bapisoa le lithethefatsi tsa vasodilator, e ntse e e-na le phello e ntle ntle le tšebeliso ea tharollo ea Chemicalbook ntle le ho itšetleha ka ho hlaphoheloa ha molumo o feletseng. Ha e bapisoa le naloxone, ha e hanyetsane le li-receptor tsa μ-opioid, ha e ame tšebeliso ea morphine, 'me e loketse ka ho khetheha bakeng sa ts'oaetso e bohloko. Ho feta moo, prorelin e na le chefo e tlaase, bophara ba tekanyo e kholo ea phekolo, 'me ha e na liphello tsa teratogenic, mutagenic le tse bolaeang. Kahoo prorelin e ka 'na ea e-ba sehlopha se secha se tšepisang sa lithethefatsi tse thibelang ho sisinyeha. Hajoale, ho sithabela maikutlo e se e le sesosa se seholo sa lefu ho batho ka mor'a lefu la pelo le methapo ea mali le hlahala, 'me karolo e fetang 30 lekholong ea batho ba shoang ka lebaka la ts'oaetso e bakoa ke ho makala. Lisosa tse ling tsa ho tsieleha tse kang septic shock (ho shoa ho fihlela ho 30% ho isa ho 50%), ho tšoha ha anaphylactic, ho tšoha ha mali le hona ho tloaelehile. Leha ho le joalo, lithethefatsi tse thibelang ho sisinyeha li ntse li e-na le mefokolo e mengata, kahoo ke habohlokoa haholo ho hlahisa lithethefatsi tse ncha tse thibelang ho sisinyeha

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