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  • I-TRH cas 24305-27-9 ngexabiso lentengiso

Jul . 05, 2023 15:15 Buyela kuluhlu

I-TRH cas 24305-27-9 ngexabiso lentengiso



I-TRH cas 24305-27-9 ngexabiso lentengiso

I-Protirelin (eyayisakuba yi-thyrotropin-releasing hormone) yi-hormone ye-tripeptide ekhutshwa yi-hypothalamus. Yaqala yacocwa yaza yadityaniswa kwi-hypothalamic tissue yeegusha neehagu ekupheleni kweminyaka yoo-1960. I-TRH Chemicalbook isasazwa ngokubanzi kwinkqubo ye-nervous central kunye namanye amalungu e-peripheral. Ukongeza kwimiphumo ye-endocrine, i-TRH iphinda idlale indima ye-neurotransmitter ye-excitatory endogenous, enokuvelisa uluhlu olubanzi lweziphumo eziphambili kunye ne-peripheral. Inefuthe elithile elichasayo kwi-endogenous opioid receptors, kodwa ayichasani nefuthe le-analgesic ye-morphine, kwaye iprorelin yaxelwa okokuqala ukuba ine-anti-shock effect kwi-1981.

Ukongeza kwonyango lokutshatyalaliswa, iprorelin inezinye izinto ezisetyenziswayo, ezifana nonyango lwe-hypothalamic hypothyroidism, i-hyperthyroidism ephakathi kwi-endocrinology. Isetyenziswa kwi-psychiatry ukunyanga ukudakumba kunye ne-schizophrenia. I-Neurology isetyenziselwa ukunyanga ubuchopho kunye nokulimala kwentambo yomgogodla, i-coma yezizathu ezahlukeneyo, i-amyotrophic lateral sclerosis, i-spinocerebellar degeneration, i-senile dementia, i-epilepsy, njl. Ukuxilongwa kokuxilongwa kwe-hyperthyroidism. Ke ngoko, iprorelin lichiza elinexabiso elilungileyo lophuhliso kwaye ifanele ukufundwa ngakumbi ukuze yandise ukusetyenziswa kwayo.

Isicelo 1. Unyango lokothuka; 2. Unyango lwe-hypothalamic hypothyroidism kunye ne-central hyperthyroidism kwisebe eliyimfihlo; 3. Unyango lwengqondo lokudakumba kunye ne-schizophrenia; 4. I-Neurochemicalbook isetyenziselwa ukunyanga ubuchopho kunye nokulimala komgogodla, i-coma yezizathu ezahlukahlukeneyo, i-amyotrophic lateral sclerosis, i-spinocerebellar degeneration, i-senile dementia, i-epilepsy, njl.; 5. Ukuxilongwa kokuxilongwa kwe-hyperthyroidism.

I-Prorelin yi-hormone ye-tripeptide emzimbeni, i-chemical structure ilula, yenziwe, i-powder eyomileyo ingagcinwa kwiqondo lokushisa lonyaka omnye, i-4 ℃ yokugcina iminyaka emininzi, ixabiso liphakathi. Idosi ye-Pharmacological ye-prorelin inefuthe elicacileyo lokuchasa ukothuka kwiintlobo ezahlukeneyo zokutyhutyha, ezifana ne-hemorrhagic, i-infectious, i-traumatic, i-spinal shock inesiphumo esicacileyo sonyango, uncwadi lunike ingxelo yokuba nayo inefuthe elichasayo kwi-anaphylactic shock, i-activator platelet kunye ne-leukotriene-induced hypotension, kunye ne-anti-shock effect iphezulu kuneziyobisi eziqhelekileyo ezichasayo kwiinkalo ezininzi. Ngokomzekelo, xa kuthelekiswa neziyobisi ze-vasoconstricting, ukunyuka koxinzelelo kumodareyitha, kwaye ukunyuka koxinzelelo kuphucula i-microcirculation. Xa kuthelekiswa neziyobisi ze-vasodilator, kusenomphumo omhle ngaphandle kokusetyenziswa kwesisombululo se-Chemicalbook ngaphandle kokuxhomekeka ekubuyiseleni umthamo opheleleyo. Xa kuthelekiswa ne-naloxone, ayichasananga ne-μ-opioid receptors, ayichaphazeli ukusetyenziswa kwe-morphine, kwaye ifaneleke ngokukodwa ukutshitshiswa okubuhlungu. Ngaphezu koko, iprorelin inobuthi obuphantsi, ububanzi bedosi yonyango enkulu, kwaye akukho teratogenic, mutagenic kunye nemiphumo ebulalayo. Ngoko iprorelin isenokuba ludidi olutsha oluthembisayo lwamachiza okulwa nokhwankqiso. Okwangoku, umonzakalo uye waba ngunobangela ophambili wokufa kwabantu emva kwesifo sentliziyo kunye ne-tumor, kwaye ngaphezulu kwe-30% yabantu ababhubhileyo ngenxa yomothuko. Ezinye oonobangela bomothuko ezifana ne-septic shock (ukufa ukuya kuma-30% ukuya kuma-50%), ukothuka kwe-anaphylactic, ukothuka kwe-hemorrhagic nazo zixhaphakile. Nangona kunjalo, amachiza okuthomalalisa aneentsilelo ezininzi, ngoko ke kubaluleke kakhulu ukuphuhlisa amachiza amatsha okulwa nokungcangcazela

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