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  • TRH cas 24305-27-9 ni osunwon owo

Jul. 05, 2023 15:15 Pada si akojọ

TRH cas 24305-27-9 ni osunwon owo



TRH cas 24305-27-9 ni osunwon owo

Protirelin (hormone itusilẹ thyrotropin tẹlẹ) jẹ homonu tripeptide ti a tu silẹ nipasẹ hypothalamus. O jẹ mimọ ni akọkọ ati iṣelọpọ lati inu àsopọ hypothalamic ti agutan ati elede ni ipari awọn ọdun 1960. Iwe kemikali TRH ti pin kaakiri ni eto aifọkanbalẹ aarin ati diẹ ninu awọn ara agbeegbe. Ni afikun si awọn ipa endocrine, TRH tun ṣe ipa ti neurotransmitter excitatory endogenous, eyiti o le gbejade ọpọlọpọ awọn ipa aarin ati agbeegbe. O ni ipa antagonistic kan lori awọn olugba opioid endogenous, ṣugbọn ko ṣe atako ipa analgesic ti morphine, ati pe prorelin ni a kọkọ royin lati ni ipa anti-mọnamọna ni ọdun 1981.

Ni afikun si itọju mọnamọna, prorelin ni awọn lilo miiran, gẹgẹbi itọju hypothalamic hypothyroidism, hyperthyroidism aarin ni endocrinology. O ti wa ni lo ninu Awoasinwin lati toju şuga ati schizophrenia. Ẹkọ-ara ti wa ni lilo lati toju ọpọlọ ati ọpa ẹhin nosi, coma ti awọn orisirisi awọn okunfa, amyotrophic lateral sclerosis, spinocerebellar degeneration, senile iyawere, warapa, ati be be lo. Aisan fun ayẹwo ti hyperthyroidism. Nitorinaa, prorelin jẹ oogun ti o ni iye idagbasoke to dara ati pe o yẹ iwadi siwaju sii lati faagun ohun elo rẹ.

Ohun elo 1. Itoju ti mọnamọna; 2. Itoju ti hypothalamic hypothyroidism ati hyperthyroidism aarin ni ẹka ikọkọ; 3. Itọju ọpọlọ ti ibanujẹ ati schizophrenia; 4. Iwe Neurochemical ni a lo lati ṣe itọju ọpọlọ ati ọgbẹ ọgbẹ ẹhin, coma ti awọn idi pupọ, sclerosis lateral amyotrophic, spinocerebellar degeneration, senile dementia, warapa, ati bẹbẹ lọ; 5. Ayẹwo fun ayẹwo ti hyperthyroidism.

Prorelin jẹ homonu tripeptide ninu ara, ọna kemikali jẹ irọrun ti o rọrun, ti jẹ sintetiki, didi-iyẹfun didi le wa ni ipamọ ni iwọn otutu yara fun ọdun kan, ibi ipamọ 4℃ fun ọdun pupọ, idiyele jẹ iwọntunwọnsi. Iwọn elegbogi ti prorelin ni ipa ipakokoro ti o han gbangba lori ọpọlọpọ mọnamọna ti iṣan ẹjẹ, gẹgẹ bi ẹjẹ, àkóràn, ọgbẹ, mọnamọna ọpa ẹhin ni ipa itọju ailera ti o han gbangba, awọn iwe ti royin pe o tun ni ipa anti-mọnamọna lori mọnamọna anaphylactic, Akitiyan platelet ati leukotriene-induced hypotension, ati awọn oniwe-egboogi-mọnamọna jẹ superior si wọpọ egboogi-mọnamọna oloro ni ọpọlọpọ awọn aaye. Fun apẹẹrẹ, ni akawe pẹlu awọn oogun vasoconstricting, ilosoke titẹ jẹ iwọntunwọnsi diẹ sii, ati ilosoke titẹ tun ṣe ilọsiwaju microcirculation. Ti a bawe pẹlu awọn oogun vasodilator, o tun ni ipa ti o dara laisi lilo ojutu Kemikali laisi gbigbekele gbigba iwọn didun ni kikun. Ti a bawe pẹlu naloxone, ko ṣe atako awọn olugba μ-opioid, ko ni ipa lori lilo morphine, ati pe o dara julọ fun mọnamọna ikọlu. Pẹlupẹlu, prorelin ni majele kekere, iwọn iwọn lilo itọju ailera nla, ati pe ko si teratogenic, mutagenic ati awọn ipa apaniyan. Nitorinaa prorelin le jẹ kilasi tuntun ti o ni ileri ti awọn oogun antishock. Ni bayi, ibalokanjẹ ti di idi pataki ti iku ninu eniyan lẹhin arun inu ọkan ati ẹjẹ ati tumo, ati pe diẹ sii ju 30% awọn iku ninu ibalokanjẹ jẹ lati mọnamọna. Awọn okunfa ipaya miiran gẹgẹbi mọnamọna septic (iku to 30% si 50%), mọnamọna anafilactic, mọnamọna ẹjẹ jẹ tun wọpọ. Sibẹsibẹ, awọn oogun antishock tun ni ọpọlọpọ awọn aito, nitorinaa o ṣe pataki pupọ lati ṣe agbekalẹ awọn oogun antishock tuntun

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