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  • TRH cas 24305-27-9 pamtengo wamba

Jul. 05, 2023 15:15 Bwererani ku mndandanda

TRH cas 24305-27-9 pamtengo wamba



TRH cas 24305-27-9 pamtengo wamba

Protirelin (yomwe kale inali thyrotropin-release hormone) ndi timadzi ta tripeptide totulutsidwa ndi hypothalamus. Idayeretsedwa koyamba ndikupangidwa kuchokera ku minofu ya hypothalamic ya nkhosa ndi nkhumba kumapeto kwa zaka za m'ma 1960. TRH Chemicalbook imafalitsidwa kwambiri m'kati mwa mitsempha yapakati ndi ziwalo zina zotumphukira. Kuphatikiza pa zotsatira za endocrine, TRH imagwiranso ntchito ya endogenous excitatory neurotransmitter, yomwe imatha kutulutsa zotsatira zapakati komanso zotumphukira. Ili ndi zotsatira zotsutsana ndi zolandilira opioid, koma sizitsutsana ndi zotsatira za morphine, ndipo prorelin idanenedwa koyamba kukhala ndi anti-shock effect mu 1981.

Kuphatikiza pa chithandizo chodzidzimutsa, prorelin ilinso ndi ntchito zina, monga chithandizo cha hypothalamic hypothyroidism, chapakati hyperthyroidism mu endocrinology. Amagwiritsidwa ntchito pazamisala pochiza kupsinjika ndi schizophrenia. Neurology imagwiritsidwa ntchito pochiza kuvulala kwaubongo ndi msana, chikomokere pazifukwa zosiyanasiyana, amyotrophic lateral sclerosis, kuchepa kwa spinocerebellar, dementia, khunyu, ndi zina zambiri. Kuzindikira matenda a hyperthyroidism. Chifukwa chake, prorelin ndi mankhwala omwe ali ndi phindu labwino lachitukuko ndipo akuyenera kuphunziranso kuti awonjezere kugwiritsa ntchito kwake.

Ntchito 1. Chithandizo cha mantha; 2. Chithandizo cha hypothalamic hypothyroidism ndi chapakati hyperthyroidism mu secretory dipatimenti; 3. Chithandizo chamaganizo cha kuvutika maganizo ndi schizophrenia; 4. Neurochemicalbook imagwiritsidwa ntchito pochiza kuvulala kwa ubongo ndi msana, chikomokere cha zifukwa zosiyanasiyana, amyotrophic lateral sclerosis, kuchepa kwa spinocerebellar, kusokonezeka kwa ubongo, khunyu, ndi zina zotero; 5. Kuzindikira matenda a hyperthyroidism.

Prorelin ndi hormone ya tripeptide m'thupi, kapangidwe kake kamakhala kosavuta, kamakhala kopanga, ufa wowuma wowuma ukhoza kusungidwa kutentha kwa chaka chimodzi, 4 ℃ kusungidwa kwa zaka zingapo, mtengo wake ndi wocheperako. Pharmacological mlingo wa prorelin ali bwino odana ndi mantha zotsatira zosiyanasiyana circulatory mantha, monga hemorrhagic, matenda, zoopsa, msana mantha ali bwino achire zotsatira, mabuku inanena kuti alinso odana ndi mantha kwambiri anaphylactic mantha, kuphatikizika kwa mapulateleti ndi leukotriene-induced hypotension, ndipo zotsatira zake zotsutsana ndi mantha zimaposa mankhwala wamba odana ndi mantha m'mbali zambiri. Mwachitsanzo, poyerekeza ndi mankhwala a vasoconstricting, kuthamanga kwapakati kumakhala kocheperako, ndipo kuwonjezereka kwa kuthamanga kumathandizanso kuti microcirculation ikhale bwino. Poyerekeza ndi mankhwala a vasodilator, imakhalabe ndi zotsatira zabwino popanda kugwiritsa ntchito Chemicalbook yankho popanda kudalira kuchira kwathunthu. Poyerekeza ndi naloxone, sizimatsutsana ndi μ-opioid receptors, sizimakhudza kugwiritsa ntchito morphine, ndipo ndizoyenera kwambiri kugwedezeka koopsa. Kuphatikiza apo, prorelin ili ndi kawopsedwe kakang'ono, kukula kwakukulu kwamankhwala ochizira, komanso alibe teratogenic, mutagenic ndi zowopsa. Choncho prorelin ikhoza kukhala gulu latsopano lodalirika la mankhwala oletsa kugwedeza. Pakali pano, zoopsa zakhala zomwe zimayambitsa imfa kwambiri mwa anthu pambuyo pa matenda a mtima ndi chotupa, ndipo oposa 30% amafa chifukwa cha zoopsa. Zina zomwe zimachititsa mantha monga septic shock (imfa mpaka 30% mpaka 50%), anaphylactic shock, hemorrhagic shock ndizofalanso. Komabe, mankhwala oletsa kugwedezeka akadali ndi zofooka zambiri, choncho ndikofunikira kwambiri kupanga mankhwala atsopano oletsa kugwedezeka

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