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  • TRH cas 24305-27-9 qiimo jumlo ah

Jul 05, 2023 15:15 Ku laabo liiska

TRH cas 24305-27-9 qiimo jumlo ah



TRH cas 24305-27-9 qiimo jumlo ah

Protirelin (oo hore u ahaan jiray hoormoonka sii daaya thyrotropin) waa hormoon tripeptide ah oo ay sii daysay hypothalamus. Waxaa markii ugu horreysay la nadiifiyay oo laga sameeyay unugyo hypothalamic ah oo ido iyo doofaarro ah dabayaaqadii 1960-meeyadii. Kiimikada TRH ayaa si weyn ugu qaybsan habka dhexe ee neerfayaasha iyo qaar ka mid ah xubnaha durugsan. Marka lagu daro saameynta endocrine, TRH waxay sidoo kale ka ciyaartaa doorka neurotransmitter-ka firfircoonida, kaas oo soo saari kara saameyn ballaaran oo dhexe iyo durugsan. Waxay leedahay saameyn liddi ku ah qaar ka mid ah receptors opioid endogenous, laakiin kama soo horjeedo saameynta xanuunka morphine, iyo prorelin ayaa markii ugu horreysay lagu soo warramey inay leedahay saameyn liddi ku ah shoogga 1981.

Marka lagu daro daaweynta shoogga, prorelin waxay leedahay adeegsiyo kale, sida daaweynta hypothalamic hypothyroidism, hyperthyroidism dhexe ee endocrinology. Waxa loo adeegsadaa cilmu-nafsiga si loo daweeyo niyad-jabka iyo schizophrenia. Neerfaha waxaa loo isticmaalaa in lagu daweeyo dhaawacyada maskaxda iyo laf dhabarta, kooma sababo kala duwan, amyotrophic lateral sclerosis, spinocerebellar degeneration, waayeelka waallida, suuxdin, iwm. Ogaanshaha ogaanshaha hyperthyroidism. Sidaa darteed, prorelin waa daawo leh qiime horumarineed oo wanaagsan waxayna u qalantaa daraasad dheeri ah si loo ballaariyo codsigeeda.

Codsiga 1. Daawaynta shoogga; 2. Daaweynta hypothalamic hypothyroidism iyo hyperthyroidism dhexe ee qaybta qarsoodiga ah; 3. Daaweynta dhimirka ee niyad-jabka iyo schizophrenia; 4. Buuga neurochemical waxaa loo isticmaalaa in lagu daweeyo dhaawaca maskaxda iyo laf dhabarta, kooma sababo kala duwan, amyotrophic lateral sclerosis, spinocerebellar degeneration, waallida waayeelka, suuxdin, iwm; 5. Ogaanshaha ogaanshaha hyperthyroidism.

Prorelin waa hormoonka tripeptide ee jirka, qaabdhismeedka kiimikaad waa mid fudud, wuxuu ahaa synthetic, budada qallalan ee la qaboojiyey waxaa lagu kaydin karaa heerkulka qolka hal sano, 4 ℃ kaydinta dhowr sano, qiimuhu waa dhexdhexaad. Qiyaasta dawooyinka ee prorelin waxay leedahay saameyn cad oo anti-shoog ah oo ku saabsan noocyada kala duwan ee shoogga wareegga dhiigga, sida dhiig-baxa, caabuqa, dhaawacyada, shoogga laf-dhabarka ayaa leh saameyn daweyn oo cad, suugaanta ayaa sheegay in ay sidoo kale leedahay saameyn liddi ku ah shoogga anaphylactic. Dhaqdhaqaaqa platelet iyo leukotriene-ku-dhisnaanta hypotension, iyo saameynteeda ka-hortagga shoogga ayaa ka sarreeya daawooyinka caadiga ah ee ka-hortagga shoogga dhinacyo badan. Tusaale ahaan, marka la barbardhigo daawooyinka vasoconstrictive, cadaadiska cadaadiska ayaa ah mid dhexdhexaad ah, cadaadiska cadaadiska ayaa sidoo kale wanaajiya microcirculation. Marka la barbardhigo daawooyinka vasodilator, waxay weli leedahay saameyn wanaagsan iyada oo aan la isticmaalin xalalka Kiimikada iyada oo aan ku tiirsanayn soo kabashada mugga buuxda. Marka la barbar dhigo naloxone, kama soo horjeedo μ-opioid reseptors, ma saameynayso isticmaalka morphine, waxayna si gaar ah ugu habboon tahay shoogga naxdinta leh. Intaa waxaa dheer, prorelin waxay leedahay sun yar, ballac qiyaasta daweynta weyn, mana laha teratogenic, mutagenic iyo saameyn dil ah. Markaa prorelin waxay noqon kartaa nooc cusub oo rajo leh oo ah dawooyinka lidka-shoogga. Waqtigan xaadirka ah, dhaawacu wuxuu noqday sababta ugu weyn ee dhimashada bini'aadamka ka dib cudurrada wadnaha iyo xididada, iyo in ka badan 30% dhimashada dhaawacyada ayaa ah naxdin. Sababaha kale ee shoogga sida shoogga septica (dhimasho ilaa 30% ilaa 50%), shoogga anaphylactic, shoogga dhiigbaxa ayaa sidoo kale caan ah. Si kastaba ha ahaatee, daawooyinka ka hortagga shoogga ayaa weli leh cillado badan, sidaas darteed aad bay muhiim u tahay in la sameeyo dawooyin cusub oo ka hortagga shoogga

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