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  • I-TRH cas 24305-27-9 ngentengo yesamba

Jul. 05, 2023 15:15 Buyela ohlwini

I-TRH cas 24305-27-9 ngentengo yesamba



I-TRH cas 24305-27-9 ngentengo yesamba

I-Protirelin (eyayiyi-hormone ekhulula i-thyrotropin) iyihomoni ye-tripeptide ekhishwa i-hypothalamus. Yaqala ukuhlanzwa futhi yahlanganiswa kusuka kuzicubu ze-hypothalamic zezimvu nezingulube ngasekupheleni kwawo-1960. I-TRH Chemicalbook isatshalaliswa kabanzi ohlelweni lwezinzwa olumaphakathi nakwezinye izitho zomzimba. Ngokungeziwe emiphumeleni ye-endocrine, i-TRH iphinde idlale indima ye-endogenous excitatory neurotransmitter, engakhiqiza imiphumela eminingi emaphakathi ne-peripheral. Inomphumela othile ophikisayo kuma-endogenous opioid receptors, kodwa ayiphikisani nomphumela we-morphine we-analgesic, futhi i-prorelin yabikwa okokuqala ukuthi inomphumela wokulwa nokushaqeka ngo-1981.

Ngaphezu kokwelashwa kokushaqeka, i-prorelin inokunye ukusetshenziswa, njengokwelashwa kwe-hypothalamic hypothyroidism, i-hyperthyroidism ephakathi ku-endocrinology. Isetshenziswa ekwelapheni kwengqondo ukwelapha ukudangala kanye ne-schizophrenia. I-Neurology isetshenziselwa ukwelapha ukulimala kobuchopho nomgogodla, i-coma yezimbangela ezihlukahlukene, i-amyotrophic lateral sclerosis, i-spinocerebellar degeneration, i-senile dementia, isithuthwane, njll. Ukuxilongwa kokuxilongwa kwe-hyperthyroidism. Ngakho-ke, i-prorelin iyisidakamizwa esinenani elihle lokuthuthuka futhi ifanelwe ukufundwa okwengeziwe ukuze kwandiswe ukusetshenziswa kwayo.

Isicelo 1. Ukwelashwa kokushaqeka; 2. Ukwelashwa kwe-hypothalamic hypothyroidism kanye ne-hyperthyroidism emaphakathi emnyangweni we-secretory; 3. Ukwelashwa kwengqondo yokucindezeleka kanye nengqondo; 4. I-Neurochemicalbook isetshenziselwa ukwelapha ukulimala kobuchopho nomgogodla, i-coma yezimbangela ezihlukahlukene, i-amyotrophic lateral sclerosis, i-spinocerebellar degeneration, i-senile dementia, isithuthwane, njll.; 5. Ukuxilongwa kokuxilongwa kwe-hyperthyroidism.

I-Prorelin iyi-hormone ye-tripeptide emzimbeni, isakhiwo samakhemikhali silula, senziwe, impushana efriziwe ingagcinwa ekamelweni lokushisa unyaka owodwa, isitoreji esingu-4 ℃ iminyaka eminingana, intengo iphakathi. Umthamo we-Pharmacological we-prorelin unomphumela ocacile wokulwa nokushaqeka ezinhlobonhlobo zokushaqeka kwe-circulatory, njenge-hemorrhagic, ezithathelwanayo, ezibuhlungu, ukushaqeka komgogodla kunomphumela ocacile wokwelapha, izincwadi zibike ukuthi nazo zinomphumela wokulwa nokushaqeka ekushaqekeni kwe-anaphylactic, i-activator platelet kanye ne-leukotriene-induced hypotension, futhi umphumela wayo wokulwa nokushaqeka uphakeme kunezidakamizwa ezivamile zokulwa nokushaqeka ezicini eziningi. Isibonelo, uma kuqhathaniswa nezidakamizwa ze-vasoconstricting, ukwanda kwengcindezi kumaphakathi, futhi ukwanda kwengcindezi nakho kuthuthukisa i-microcirculation. Uma kuqhathaniswa nezidakamizwa ze-vasodilator, isenomphumela omuhle ngaphandle kokusetshenziswa kwesisombululo se-Chemicalbook ngaphandle kokuthembela ekubuyiseleni ivolumu ephelele. Uma kuqhathaniswa ne-naloxone, ayiphikisani nama-receptors e-μ-opioid, ayithinti ukusetshenziswa kwe-morphine, futhi ifaneleka ngokukhethekile ukushaqeka okubuhlungu. Ngaphezu kwalokho, i-prorelin inobuthi obuphansi, ububanzi bethamo lokwelapha elikhulu, futhi ayikho imiphumela ye-teratogenic, mutagenic kanye nebulalayo. Ngakho i-prorelin ingase ibe isigaba esisha esithembisayo semithi elwa nokushaqeka. Njengamanje, ukuhlukumezeka sekuyimbangela enkulu yokufa kwabantu ngemuva kwesifo senhliziyo nemithambo yegazi kanye nesimila, futhi ngaphezu kuka-30% wabantu abashona ngenxa yokuhlukumezeka ngenxa yokushaqeka. Ezinye izimbangela zokushaqeka njengokushaqeka kwe-septic (ukufa kufika ku-30% kuya ku-50%), ukushaqeka kwe-anaphylactic, ukushaqeka kwe-hemorrhagic nazo zivamile. Kodwa-ke, izidakamizwa ezilwa nokushaqeka zisenamaphutha amaningi, ngakho-ke kubaluleke kakhulu ukwenza imishanguzo emisha ye-antishock

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