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  • Thymalin cas 63958-90-7 whatsapp:+86-19031013676

Agasti . 08, 2023 15:20 Buyela kuluhlu

Thymalin cas 63958-90-7 whatsapp:+86-19031013676



Thymalin cas 63958-90-7

Ifanelekile kwizifo eziziiprayimari kunye nesekondari, izifo ezibangelwa kukungasebenzi komzimba, ukunyangwa kwe-adjuvant ye-tumor, i-anemia ye-aplastic, i-hepatitis yentsholongwane ebukhali kunye nengapheliyo, kwaye ingasetyenziselwa i-lupus erythematosus, i-rheumatoid arthritis, i-asthma ye-allergic, njl.

Iqondo lokubila leSerum thymic factor 1658.9 + / - 65.0 ° C (Kuxelwe kwangaphambili) 1.417 + 0.06 g/cm3 density (Kuqikelelwe) iimeko zokugcina - 20 ° C solubility dChemicalbookeionizedwater: i-soluble acidity coefficient (pKa) 3.0 8±0.10(Kuxelwe kwangaphambili) Umgubo weLyophilized Umbala omhlophe

I-Serum thymus factor yinto ebalulekileyo yokukhuthaza ukuhlukana kwe-lymphocyte kunye nokuphucula umsebenzi wayo. Inokuvuselela ukusebenza kweeseli zomzimba, ukulawula ukusebenza komzimba kunye nokuphucula ukungatheleleki kweselula. Imveliso yeMichiza inokulawula ukusebenza kwe-immune yeselula, kunye ne-anti-aging, imiphumo ye-antiviral. Ubushushu buzinzile, umsebenzi webhayoloji awunciphi kwi-80 ℃, kwaye umsebenzi webhayoloji uyanyamalala emva kokuba i-hydrolyzed ibe yi-amino acids. I-calf thymus yayisetyenziswe njengezinto eziluhlaza, amafutha, i-fascia kunye nezinye izicubu ze-non-thymus zaye zasuswa, zafakwa efrijini kwi-20 ℃, zahlanjwa ngamanzi ahlambulukileyo ahlambulukileyo, kwaye zigaywe kwisigrisi senyama esizintsholongwane. Ngokomlinganiselo wobunzima be-1: 1, i-thymus echotshoziweyo ikhutshwe ngamanzi abandayo ukuze ifakwe isitofu (amanzi aseTshayina akhutshwe ngokugqithiswa okuphantsi kunye nokunyibilika okubandayo), okunokwenza i-peptide esebenzayo inyibilike ngokupheleleyo emanzini kwaye iphucule isivuno. Ngokweengxelo zangaphandle, inokuphinda ikhutshwe nge-saline eqhelekileyo) ixutywe, ifakwe kwi-10000r / min i-high-speed tissue masher, kunye ne-mashed for 1min ukwenza i-homogenize. Ithole i-thymus [umhlaba]→ i-thymus etyumziweyo [amanzi abandayo okutofwa]→[10000r/min,1min] I-Thymus homogenate inxalenye ye-thermal denaturation, centrifugation, filtration I-thymus homogenate yafunxwa yaza yatsalwa ngaphantsi kwe-10℃, yaze yafakwa emkhenkceni kwi -2chemical book0 ℃ nge48h. Emva kokunyibilika, gxobhoza kwibhafu yamanzi kunye nobushushu kwi-80 ℃, gcina i-5min, upholise ngokukhawuleza, upholise kwi-20℃ ye-2-3d. Emva kokunyibilika, i-supernatant yayiyi-centrifuged kwi-2 ℃ kwi-5000r / min ye-40min, kwaye yahluzwa phantsi koxinzelelo oluncitshisiweyo (i-pulp yesihluzi okanye i-0.22μm i-microporous filter membrane) ukufumana isicatshulwa esicacileyo se-polypeptide esebenzayo. I-Thymus homogenate [isicatshulwa esingaphantsi kwe-10℃]→[-20℃,48h] isisombululo sokukhenkceza [80℃,5min]→[5000r/min,40min centrifuge] Isicatshulwa se-peptide esisebenzayo i-ultrafiltration, ukucoca, ukupakishwa, lyophilization Isicatshulwa esicacisiweyo sisicatshulwa se-peptide esebenzayo. I-membrane ye-ultrafiltration (enokuthi igcine ubunzima be-molecular mass ngaphantsi kwe-10,000) ukufumana isisombululo esisulungekileyo. Ifriji kwi -20 ℃. Emva kokuphumelela uvavanyo, i-3% ye-mannitol (i-excipient) yongezwa, i-sterilized kwaye yahluzwa, yapakishwa, yomiswa ngumkhenkce, kunye ne-thymosin yenaliti yafunyanwa. Isicatshulwa sepolypeptide esebenzayo [i-ultrafiltration inwebu]→[Mr<10000] isisombululo esisulungekileyo [ukumisa umkhenkce]→[3% mannitol] thymosin yenaliti (Qaphela: Inkqubo yonke yokusebenza kunye nezixhobo kufuneka ziqhutywe ngokuhambelana nendlela yokusebenza kwe-aseptic.)

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