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  • Thymalin cas 63958-90-7 whatsapp:+86-19031013676

Aug. 08, 2023 15:20 Buyela ohlwini

Thymalin cas 63958-90-7 whatsapp:+86-19031013676



I-Thymalin cas 63958-90-7

Ilungele izifo eziyisisekelo zokuzivikela komzimba, izifo ezibangelwa ukungasebenzi kahle kwamasosha omzimba, ukwelashwa kwe-adjuvant yezimila, i-aplastic anemia, i-acute kanye ne-viral hepatitis engapheli, futhi ingasetshenziselwa i-lupus erythematosus, i-rheumatoid arthritis, i-asthma ye-allergen, njll.

Iphuzu elibilisayo le-Serum thymic factor 1658.9 + / - 65.0 ° C (Kubikezelwe) 1.417 + 0.06 g/cm3 ukuminyana (Okubikezelwe) izimo zokugcina - 20 ° C ukunyibilika kwe-dChemicalbookeionizedwater: i-acidity encibilikayo i-coefficient (pKa) 3.0 8±0.10(Kubikezelwe) I-Lyophilizedpowder Umbala omhlophe

I-Serum thymus factor iyisici esibalulekile sokuthuthukisa ukuhlukaniswa kwe-lymphocyte nokuthuthukisa umsebenzi wayo. Ingavuselela ukusebenza kwamangqamuzana omzimba, ilawule ukusebenza kwamasosha omzimba futhi ithuthukise ukuzivikela kwamangqamuzana okungaqondile. Umkhiqizo wamakhemikhali ungalawula ukusebenza kokuzivikela komzimba kwamaselula, nge-anti-aging, nemiphumela elwa namagciwane. Azinzile ekushiseni, umsebenzi webhayoloji awehli ku-80℃, futhi umsebenzi webhayoloji uyanyamalala ngemva kokufakwa nge-hydrolyzed ku-amino acid. I-calf thymus yayisetshenziswa njengempahla eluhlaza, amafutha, i-fascia nezinye izicubu ezingezona i-thymus zasuswa, zafakwa esiqandisini ku--20 ℃, zigezwa ngamanzi angenalutho acwecwe, futhi zigaywe ngomshini wokugaya inyama inzalo. Ngokwesilinganiso esikhulu se-1: 1, i-thymus echotshoziwe ikhishwa ngamanzi abandayo ukuze umjovo (amanzi aseShayina akhishwa ngokungena okuphansi nokuncibilika okubandayo), okungenza i-peptide esebenzayo incibilike ngokugcwele emanzini futhi ithuthukise isivuno. Ngokwemibiko yangaphandle, ingaphinda ikhishwe ngosawoti ojwayelekile) exutshwe, ifakwe kumshini wokuhlanganisa izicubu ezinesivinini esikhulu esingu-10000r/min, bese iculwa imizuzu engu-1 ukuze kwenziwe i-homogenize. I-Calf thymus [umhlabathi]→ i-thymus echotshoziwe [amanzi abandayo omjovo]→[10000r/min,1min] I-Thymus homogenate ingxenye ye-thermal denaturation, centrifugation, filtration I-thymus homogenate yacwiliswa futhi yakhishwa ngaphansi kuka-10℃, yase iqandiswa ku -2 chemical book0 ℃ amahora angu-48. Ngemva kokuncibilika, gudluza emanzini okugeza bese ushisa ku-80℃, gcina imizuzu emi-5, uphole ngokushesha, ufake efrijini ku-20℃ isikhathi esingu-2-3d. Ngemva kokuncibilika, i-supernatant yafakwa i-centrifuged ku-2 ℃ ku-5000r/min ye-40min, bese ihlungwa ngaphansi kwengcindezi encishisiwe (i-pulp yokuhlunga noma ulwelwesi lwesihlungi se-microporous esingu-0.22μm) ukuze kutholwe ukukhishwa okucacisiwe kwe-polypeptide esebenzayo. I-Thymus homogenate [isizinda esingaphansi kuka-10℃]→[-20℃,48h] isixazululo sokuqandisa [80℃,5min]→[5000r/min,40min centrifuge] I-peptide esebenzayo ikhiphe i-ultrafiltration, ukuhlanzwa, ukupakishwa, lyophilization Ukukhishwa kwe-peptide esebenzayo Ulwelwesi lwe-ultrafiltration (elingakwazi ukugcina isisindo samangqamuzana esihlobene esingaphansi kuka-10,000) ukuze kutholwe isisombululo esicolisisiwe. Isiqandisi ku -20 ℃. Ngemuva kokuphumelela ukuhlolwa, i-3% ye-mannitol (i-excipient) yengezwe, yafakwa inzalo futhi yahlungwa, yapakishwa, yamiswa yiqhwa, kanye ne-thymosin yokujova. I-polypeptide ekhishwayo esebenzayo [ulwelwesi lwe-ultrafiltration]→[Mr<10000] isixazululo esicolisisiwe [ukumisa iqhwa]→[3% mannitol] i-thymosin yomjovo (Qaphela: Yonke inqubo yokusebenza nezinto zokusebenza kufanele zenziwe ngokuhambisana nendlela yokusebenza kwe-aseptic.)

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