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  • Icatibant acetate cas 138614-30-9

Iuch . 13, 2023 10:04 Air ais dhan liosta

Icatibant acetate cas 138614-30-9



Icatibant acetate cas 138614-30-9

Tha Icatibant Acetate na antagonist de bradykinin B2 receptor, a dh'fhaodar a chleachdadh airson làimhseachadh angioedema oighreachail.

sgrùdadh in vitro

Icatibant (10-30μM) potentiatesangiotensin III, butnotangiotensin II (cunnradh air a mheadhanachadh le angiotensinAT1receChemicalbookptors), agus Lys-des-Arg9-bradykinin, butnotdes-Arg9-bradykinin (buaidhean air am meadhanachadh leis na gabhadairean bradykininB1).

sgrùdadh in vivo

Tha Icatibant (10-30μM) a 'toirt buaidh air angiotensin III, ach chan e angiotensin II (crapadh air a mheadhanachadh le gabhadairean angiotensinAT1), agus Lys-des-Arg9-bradykinin, butnotdes-Arg9-bradykinin (buaidhean air an eadar-theangachadh leis na gabhadairean bradykininB1). Modail Ainmhidhean: luchagan boireann den t-srann CBA/J (H-Chemicalbook2k).

Dosage: 0.06,0.3, no 1.5mg / kg.

Rianachd: Rianachd subcutaneous dà uair sa latha.

Toradh: Fad an innewas as motha 93.6 ± 6.8mm leis an dosage 1.5mg / kg agus 94.0 ± 4.1mm leis an dosachadh 0.3mg / kg, a’ nochdadh buaidh casgach mòr air giorrachadh.

Feartan acetate freagairtant Suidheachadh stòraidh -20 ° C solubility DMSO: 65.0 (MaxConc.mg/mL); 47.63 (MaxConc. MM) Ethanol: 0.25 (MaxConc. MgChemicalbook/mL); 0.18 (MaxConc. MM) PBS (pH7.2): 10.0 (MaxConc. Mg/mL); 7.33 (MaxConc.mM) Acrystallinesolid

Àireamh CAS 138614-30-9

Foirmle moileciuil C59H89N19O13S.C2H4O2

Cuideam moileciuil 1364.59EINECS àireamh: -

Feartan fiosaigeach de Altybant acetate

Dùmhlachd 1.6g/cm3

Foirmle moileciuil C61H93N19O15S

Cuideam moileciuil 1364.57000

Meud cruinn 1363.68000

 

Icatibant acetate cas 138614-30-9

Tha Icatibant Acetate na antagonist de bradykinin B2 receptor, a dh'fhaodar a chleachdadh airson làimhseachadh angioedema oighreachail.

  • ailias Beurla

  • Acetate Icatibant [USAN]; (R) -Arginyl-(S)-arginyl-(S)-prolyl-(2S,4R)-(4-hydroxyprolyl)glycyl-(S)-(3-(2-thienyl)alanyl)-(S)- seryl-(R) -((1,2,3,4-tetrahydro-3-isoquinolyl)carbonyl)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S)-arginine acetate (salann); Acetate Icatibant; L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylgglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3, 4-tetrahydro-3-isoquinolinecarbonyl-L- (2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-, acetate (salann)

  • Ailias Sìneach

  • Acetabant acetate; D - bonn l-arginine - L - bonn arginine - L - glèidhte ammonia acyl - (4 r) - 4 - hydroxy - L - ammonia glèidhte stèidhichte air siùcar - 3 - (2 -) bonn thiophene - L - propylene ammonia acyl - L - sìoda ammonia acyl - (3 r) - 1, 2, 3, 4 - ceithir hydrogen Leabhar ceimigeach - 3 - isoquinoline carbonyl - (mar) 2 s, 3 as, 7-8 h - 1 h - indole -2-carbonyl-L-arginine acetate; Aitebant acetate (Aitebant acetate, HOE140); ACETATE; Acetate Aldeibant
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