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  • Icatibant acetate cas 138614-30-9

Jul 13, 2023 10:04 Ku laabo liiska

Icatibant acetate cas 138614-30-9



Icatibant acetate cas 138614-30-9

Icatibant Acetate waa antagonist of bradykinin B2 reseptor, kaas oo loo isticmaali karo in lagu daweeyo anjioedema la dhaxlo.

barashada vitro

Icatibant (10-30μM) potentiatesangiotensinIII, butnotangiotensinII (contractionmediatedbyangiotensinAT1receChemicalbookptors),iyo Lys-des-Arg9-bradykinin, laakiinnotdes-Arg9-bradykinin(saamaynta dhexdhexaadin bythebradykininB1receptors).

waxbarashada vivo

Icatibant (10-30μM) waxay xoojisaa angiotensin III, laakiin ma aha angiotensinII (contractionmediatedbyangiotensinAT1receptors), iyo Lys-des-Arg9-bradykinin, butnotdes-Arg9-bradykinin (saamaynta dhexdhexaadin bythebradykininB1receptors). Qaabka Xayawaanka: Jiirarka dheddigga ee CBA/J(H-Chemicalbook2k).

Qiyaasta: 0.06,0.3, ama 1.5mg/kg.

Maamulka:Maamulka subcutaneous laba jeer maalintii.

Natiijadu: Dhererka inewas93.6 ± 6.8mm ugu weyn oo leh 1.5mg/kg qiyaasta iyo 94.0± 4.1mm oo leh qiyaasta 0.3mg/kg, oo muujinaysa saameyn ka hortag ah oo weyn oo gaaban.

Guryaha Atebant acetate xaaladaha kaydinta -20 ° C milanka DMSO: 65.0 (MaxConc.mg/mL); 47.63 (MaxConc. MM) Ethanol: 0.25 (MaxConc. MgChemicalbook/mL); 0.18 (MaxConc. MM) PBS (pH7.2): 10.0 (MaxConc. Mg/mL); 7.33(MaxConc.mM) Acrystallinesolid

Lambarka CAS 138614-30-9

Qaacidada molecular C59H89N19O13S.C2H4O2

Miisaanka unugyada 1364.59EINECS lambarka:-

Tilmaamaha physicochemical ee Altybant acetate

Cufnaanta 1.6g/cm3

Qaaciddada molecular C61H93N19O15S

Miisaanka unugyada 1364.57000

Tirada saxda ah 1363.68000

 

Icatibant acetate cas 138614-30-9

Icatibant Acetate waa antagonist of bradykinin B2 reseptor, kaas oo loo isticmaali karo in lagu daweeyo anjioedema la dhaxlo.

  • Ingriiska oo loo yaqaan

  • Icatibant acetate [USAN]; (R)-Arginyl-(S)-arginyl-(S)-prolyl-(2S,4R)-(4-hydroxyprolyl) glycyl-(S)-(3- (2-thienyl) alanyl)-(S) seryl-(R)-((1,2,3,4-tetrahydro-3-isoquinolyl)carbonyl)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S) -arginine acetate (cusbo); Icatibant acetate; L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3- (2-thienyl) -L-alanyl-L-seryl-D-1,2,3, 4-tetrahydro-3-isoquinolinecarbonyl-L- (2alpha,3abeta,7abeta) -octahydro-1H-indole-2-carbonyl-, acetate (milix)

  • Shiine oo loo yaqaan

  • Acetabant acetate; D - l-arginine saldhigga - L - saldhigga arginine - L - ammonia acyl la ilaaliyo - (4 r) - 4 - hydroxy - L - ilaalinta ammonia acyl sonkorta ku salaysan - 3 - (2 -) saldhigga thiophene - L - propylene ammonia acyl - L - silk ammonia acyl - (3 r) - 1, 2, 3, 4 - afar kiimiko hydrogen - 3 - isoquinoline carbonyl - (sida) 2 s, 3 sida, 7-8 h - 1 h - indole -2-carbonyl-L-arginine acetate; Aitebant acetate (Aitebant acetate, HOE140); ACETATE; Aldeibant acetate
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