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Iul. 13, 2023 10:04 Ad album

Icatibant acetate cas 138614-30-9



Icatibant acetate cas 138614-30-9

Acetate antagonista est receptae bradykinin B2, quod angioedema hereditarium tractari potest.

in vitro studio

Icatibant(10-30μM)potentiatesangiotensinIII, sed notangiotensinII(contractionmediatedbyangiotensinAT1receChemicalbookptors), et Lys-des-Arg9-bradykinin, sed notdes-Arg9-bradykinin (effectis mediantibus dbythebradykininB1receptoribus).

in vivo studio

Icatibant (10-30μM) potentiates angiotensin III, sed non angiotensinII (contractionmediatedbyangiotensinAT1receptores) et Lys-des-Arg9-bradykinin, sed notdes-Arg9-bradykinin (effectis mediantibus e. Exemplar animal: Mures feminei theCBA/J (H-Chemicalbook2k) contendunt.

Dosis: 0.06,0.3, or1.5mg/kg.

Administratio: Subcutaneous administrationtwicedaily.

Consequuntur: Longitudo maxima inewas93.6±6.8mm cum 1.5mg/kg dosage et 94.0±4.1mm cum 0.3mg/kg dosis, ostendens praecaventiam notabilem effectum minuendi.

Atebant acetatas possessiones at conditiones -20°C solubilitas DMSO:65.0(MaxConc.mg/mL); 47.63 (MaxConc. MM) Ethanol: 0.25 (MaxConc. mgChemicalbook/mL); 0.18 (MaxConc. MM) PBS (pH7.2) : 10.0 (MaxConc. Mg/mL); 7.33(MaxConc.mM) Acrystallinesolid

CAS numerus 138614-30-9

Formulae hypotheticae C59H89N19O13S.C2H4O2

Pondus hypotheticum 1364.59EINECS number: -

Proprietates physicae Altybantiae acetatis

Densitas 1.6g/cm3

Formulae hypotheticae C61H93N19O15S

pondus hypotheticum 1364,57000

Massa accurata 1363.68000

 

Icatibant acetate cas 138614-30-9

Acetate antagonista est receptae bradykinin B2, quod angioedema hereditarium tractari potest.

  • Anglicus alias

  • Icatibant acetate [USAN]; glycyl-(S)-(3-(2-thienyl) alanyl)-(S)- seryl-(R)-((1,2,3,4-tetrahydro-3-isoquinolyl)carbonyl)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S)-arginine acetate (sal); Icatibant acetate; L-argininus, D-arginyl-L-arginyl-L-prolyl-trans- 4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3; 4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-, acetata.

  • Seres alias

  • Acetabant acetabant; D - l- arginine basi L - arginine basi L - conservata ammoniaci acyl - (4 r) - 4 - hydroxy - L - conservata ammoniaci acyl saccharo substructio - 3 - (2 -) basi thiophene - L - propylene ammoniaci acyl - L - ammoniaci serici acyl - ( 3 r ) - 1, 2, 3, 4 - s. -2-carbonyl-L-arginine acetato; Aitebant acetate (Aitebant acetate, HOE140); ACETATE; Aldeibant acetate
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