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  • I-Icatibant acetate cas 138614-30-9

Jul. 13, 2023 10:04 Buyela ohlwini

I-Icatibant acetate cas 138614-30-9



I-Icatibant acetate cas 138614-30-9

I-Icatibant Acetate imelene ne-bradykinin B2 receptor, engasetshenziswa ukwelapha i-angioedema yofuzo.

isifundo se-in vitro

I-Icatibant(10-30μM) inamandla e-sangiotensinIII,kodwa i-notangiotensinII(i-contractionmediatedbyangiotensinAT1receChemicalbookptors),kanye ne-Lys-des-Arg9-bradykinin,butnotdes-Arg9-bradykinin(imiphumela ihlanganiswe yi-thebradykininB1).

esifundweni se-vivo

I-Icatibant (10-30μM) yenza i-angiotensin III, kodwa hhayi i-angiotensinII(contractionmediatedbyangiotensinAT1receptors), kanye neLys-des-Arg9-bradykinin, butnotdes-Arg9-bradykinin(imiphumela ixhunywe yi-thebradykininB1receptors). Imodeli Yezilwane:Amagundane esifazane e-CBA/J(H-Chemicalbook2k)strain.

Isilinganiso: 0.06,0.3, noma 1.5mg/kg.

Ukuphatha:Ukuphatha ngaphansi kwesikhumba kabili ngosuku.

Umphumela:Ubude bobukhulu obunamandla bungama-93.6±6.8mm obunomthamo we-1.5mg/kg kanye no-94.0±4.1mm ngomthamo ongu-0.3mg/kg, okubonisa umphumela obalulekile wokuvimbela ekufinyezeni.

Izakhiwo ze-atebant acetate Izimo zesitoreji -20°C ukunyibilika kwe-DMSO:65.0(MaxConc.mg/mL); 47.63 (MaxConc. MM) I-Ethanol: 0.25 (MaxConc. MgChemicalbook/mL); 0.18 (MaxConc. MM) PBS (pH7.2) : 10.0 (MaxConc. Mg/mL); 7.33(MaxConc.mM) I-Acrystallinesolid

Inombolo ye-CAS 138614-30-9

Ifomula yemolekyuli C59H89N19O13S.C2H4O2

Isisindo se-molecule 1364.59EINECS inombolo: -

Izakhiwo ze-Physicochemical ze-Altybant acetate

Ukuminyana 1.6g/cm3

Ifomula yemolekyuli C61H93N19O15S

Isisindo samangqamuzana 1364.57000

Isisindo esinembile 1363.68000

 

I-Icatibant acetate cas 138614-30-9

I-Icatibant Acetate imelene ne-bradykinin B2 receptor, engasetshenziswa ukwelapha i-angioedema yofuzo.

  • Isibizo sesiNgisi

  • I-Icatibant acetate [USAN]; (R)-Arginyl-(S)-arginyl-(S)-prolyl-(2S,4R)-(4-hydroxyprolyl)glycyl-(S)-(3-(2-thienyl)alanyl)-(S)- i-seryl-(R)-((1,2,3,4-tetrahydro-3-isoquinolyl)carbonyl)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S)-arginine acetate (usawoti); I-acetate ye-icatibant; I-L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3, 4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-, acetate (usawoti)

  • Isibizo sesiShayina

  • I-acetabant acetate; Isisekelo se-D - l-arginine - L - isisekelo se-arginine - L - i-ammonia acyl egciniwe - (4 r) - 4 - i-hydroxy - L - i-ammonia egciniwe esekelwe kushukela - 3 - (2 -) isisekelo se-thiophene - L - propylene ammonia acyl - L - usilika ammonia acyl - (3 r) - 1, 2, 3, 4 - ezine hydrogen Chemicalbook - 3 - isoquinoline carbonyl - (as) 2 s, 3 njengoba, 7-8 h - 1 h - indole -2-carbonyl-L-arginine acetate; I-aitebant acetate (i-Aitebant acetate,HOE140); I-ACETATE; I-Aldeibant acetate
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