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  • Icatibant acetate cas 138614-30-9

Jul . 13, 2023 10:04 Buyela kuluhlu

Icatibant acetate cas 138614-30-9



Icatibant acetate cas 138614-30-9

I-Icatibant Acetate ngumchasi we-bradykinin B2 receptor, engasetyenziselwa ukuphatha i-angioedema yefa.

isifundo se-in vitro

I-Icatibant(10-30μM) inamandla esangiotensinIII, kodwanotangiotensinII(contractionmediatedbyangiotensinAT1receChemicalbookptors),kunye neLys-des-Arg9-bradykinin,butnotdes-Arg9-bradykinin(iziphumo zidibene yithebradykininB1receptors).

kwisifundo se-vivo

I-Icatibant (10-30μM) yenza i-angiotensin III, kodwa hayi i-angiotensinII(i-contractionmediatedbyangiotensinAT1receptors), kunye neLys-des-Arg9-bradykinin, kodwa notdes-Arg9-bradykinin(iziphumo zidibene yi-thebradykininB1receptors). UMzekelo Wezilwanyana:Iimpuku ezizimazi ze-CBA/J(H-Chemicalbook2k)strain.

Umthamo: 0.06,0.3, okanye1.5mg/kg.

Ulawulo:Ulawulo olungaphantsi kwe-subcutaneous kabini yonke imihla.

Isiphumo:Ubude beyona nto inkulu ine-inewas93.6±6.8mm kunye ne-1.5mg/kg dosage kunye ne-94.0±4.1mm kunye ne-0.3mg/kg yedosi, ebonisa impembelelo ebalulekileyo yokuthintela ekunciphiseni.

Iimpawu ze-atebant acetate Iimeko zokugcina -20 °C ukunyibilika kwe-DMSO: 65.0 (MaxConc.mg/mL); 47.63 (MaxConc. MM) I-Ethanol: 0.25 (MaxConc. MgChemicalbook/mL); 0.18 (MaxConc. MM) PBS (pH7.2) : 10.0 (MaxConc. Mg/mL); 7.33(MaxConc.mM) Acrystallineolid

Inombolo ye-CAS 138614-30-9

Ifomula yemolekyuli C59H89N19O13S.C2H4O2

Ubunzima bemolekyuli 1364.59EINECS inombolo: -

Iimpawu zePhysicochemical ze-Altybant acetate

Ubuninzi 1.6g/cm3

Ifomula yemolekyuli C61H93N19O15S

Ubunzima bemolekyuli 1364.57000

Ubunzima obuchanekileyo 1363.68000

 

Icatibant acetate cas 138614-30-9

I-Icatibant Acetate ngumchasi we-bradykinin B2 receptor, engasetyenziselwa ukuphatha i-angioedema yefa.

  • Igama lesiNgesi

  • I-Icatibant acetate [USAN]; (R)-Arginyl-(S)-arginyl-(S)-prolyl-(2S,4R)-(4-hydroxyprolyl)glycyl-(S)-(3-(2-thienyl)alanyl)-(S)- seryl-(R)-((1,2,3,4-tetrahydro-3-isoquinolyl)carbonyl)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S)-arginine acetate (ityuwa); I-acetate ye-Icatibant; L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3, I-4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-, i-acetate (ityuwa)

  • Igama lesiTshayina

  • Iacetate ye-acetabant; D - isiseko se-arginine - L - isiseko se-arginine - L - i-ammonia acyl egciniweyo - (4 r) - 4 - i-hydroxy - L - igcinwe i-ammonia i-acyl sugar-based - 3 - (2 -) isiseko se-thiophene - L - propylene ammonia acyl - L - isilika ammonia acyl - (3 r) - 1, 2, 3, 4 - ezine hydrogen Chemicalbook - 3 - isoquinoline carbonyl - (as) 2 s, 3 njengoko, 7-8 h - 1 h - indole -2-carbonyl-L-arginine acetate; I-aitebant acetate (i-Aitebant acetate,HOE140); I-ACETATE; Aldeibant acetate
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