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  • Icatibant acetate cas 138614-30-9

Lulju. 13, 2023 10:04 Lura għal-lista

Icatibant acetate cas 138614-30-9



Icatibant acetate cas 138614-30-9

Icatibant Acetate huwa antagonist tar-riċettur ta' bradykinin B2, li jista' jintuża biex jikkura anġjoedema ereditarja.

studju in vitro

Icatibant(10-30μM)potentiatesangiotensinIII,butnotangiotensinII(kontrazzjoni medjatabyangiotensinAT1receChemicalbookptors),andLys-des-Arg9-bradykinin,butnotdes-Arg9-bradykinin(effetti medjatibythebradykininB1receptors).

studju in vivo

Icatibant (10-30μM) isaħħaħ angiotensin III, iżda mhux angiotensinII (kontrazzjoni medjata mir-riċetturi tal-angiotensinAT1), u Lys-des-Arg9-bradykinin, iżda mhux des-Arg9-bradykinin (effetti medjati mir-riċetturi tal-bradykinin B1). Mudell tal-Annimali: Ġrieden nisa tar-razza CBA/J(H-Chemicalbook2k).

Dożaġġ: 0.06, 0.3, jew 1.5mg/kg.

Amministrazzjoni: Amministrazzjoni taħt il-ġilda darbtejn kuljum.

Riżultat: It-tul tal-intest largeintest kien 93.6 ± 6.8mm bid-dożaġġ ta '1.5mg/kg u 94.0±4.1mm bid-dożaġġ ta' 0.3mg/kg, li juri effett preventiv sinifikanti fuq it-tqassir.

Atebant acetate proprjetajiet Kondizzjonijiet ta 'ħażna -20°C solubilità DMSO:65.0(MaxConc.mg/mL); 47.63 (MaxConc. MM) Etanol: 0.25 (MaxConc. MgChemicalbook/mL); 0.18 (MaxConc. MM) PBS (pH7.2): 10.0 (MaxConc. Mg/mL); 7.33(MaxConc.mM) Solidu kristallin

Numru CAS 138614-30-9

Formula molekulari C59H89N19O13S.C2H4O2

Piż molekulari 1364.59 Numru EINECS:-

Proprjetajiet fiżikokimiċi tal-aċetat Altybant

Densità 1.6g/cm3

Formula molekulari C61H93N19O15S

Piż molekulari 1364.57000

Massa preċiża 1363.68000

 

Icatibant acetate cas 138614-30-9

Icatibant Acetate huwa antagonist tar-riċettur ta' bradykinin B2, li jista' jintuża biex jikkura anġjoedema ereditarja.

  • Alias ​​Ingliż

  • Icatibant aċetat [USAN]; (R)-Arginyl-(S)-arginyl-(S)-prolyl-(2S,4R)-(4-hydroxyprolyl)glycyl-(S)-(3-(2-thienyl)alanil)-(S)- seryl-(R)-((1,2,3,4-tetrahydro-3-isoquinolil)carbonyl)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S)-arginine acetate (melħ); Icatibant aċetat; L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3, 4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-, aċetat (melħ)

  • Psewdonimu Ċiniż

  • Aċetat tal-aċetabant; D - bażi ta 'l-arginine - L - bażi ta' arginina - L - aċil ta 'ammonja ippreservat - (4 r) - 4 - idrossi - L - ammonja aċil ippreservat ibbażat fuq zokkor - 3 - (2 -) bażi ta' thiophene - L - propylene ammonja aċil - L - silk ammonja acyl - (3 r) - 1, 2, 3, 4 - erba 'idroġenu Chemicalbook - 3 - isoquinoline carbonyl - (as) 2 s, 3 as, 7-8 h - 1 h - indol -2-carbonyl-L-arginine aċetat; Aitebant acetate (Aitebant acetate,HOE140); AĊETAT; Aldeibant aċetat
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