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Jul. 13, 2023 10:04 Hoʻi i ka papa inoa

Icatibant acetate cas 138614-30-9



Icatibant acetate cas 138614-30-9

ʻO Icatibant Acetate kahi mea kū'ē i ka bradykinin B2 receptor, hiki ke hoʻohana ʻia e mālama i ka angioedema hoʻoilina.

haʻawina in vitro

Icatibant(10-30μM)potentiatesangiotensinIII, butnotangiotensinII(contractionmediatedbyangiotensinAT1receChemicalbookptors),a me Lys-des-Arg9-bradykinin, butnotdes-Arg9-bradykinin(nā hopena i hoʻopili ʻia e nā mea hoʻokipa bradykininB1).

in vivo haʻawina

ʻO ka Icatibant (10-30μM) ka potentiates angiotensin III, akā ʻaʻole ka angiotensinII (contractionmediatedbyangiotensinAT1 receptors), a me Lys-des-Arg9-bradykinin, butnotdes-Arg9-bradykinin(effectsmediatedbythebradykininB1receptors). Ke Ana Hoʻohālike holoholona:Nā ʻiole wahine o ke kāʻili CBA/J(H-Chemicalbook2k).

ʻAi: 0.06, 0.3, a i ʻole 1.5mg/kg.

Administration: Subcutaneous administration i kēlā me kēia lā.

Ka hopena: ʻO ka lōʻihi o ka nui inewas93.6±6.8mm me ka 1.5mg/kg dosage a me 94.0±4.1mm me ka 0.3mg/kg dosage, e hōʻike ana i kahi hopena pale nui i ka pōkole.

Atebant acetate waiwai Kūlana mālama -20°C solubility DMSO:65.0(MaxConc.mg/mL); 47.63 (MaxConc. MM) Ethanol: 0.25 (MaxConc. MgChemicalbook / mL); 0.18 (MaxConc. MM) PBS (pH7.2): 10.0 (MaxConc. Mg/mL); 7.33(MaxConc.mM) Acrystallinesolid

Helu CAS 138614-30-9

Huina molekala C59H89N19O13S.C2H4O2

Kaumaha Molekala 1364.59EINECS helu:-

ʻO nā waiwai physicochemical o Altybant acetate

ʻO ka mānoanoa 1.6g/cm3

ʻAno molekole C61H93N19O15S

Kaumaha molekula 1364.57000

Nuipa pololei 1363.68000

 

Icatibant acetate cas 138614-30-9

ʻO Icatibant Acetate kahi mea kū'ē i ka bradykinin B2 receptor, hiki ke hoʻohana ʻia e mālama i ka angioedema hoʻoilina.

  • inoa Pelekane

  • Icatibant acetate [USAN]; (R)-Arginyl-(S)-arginyl-(S)-prolyl-(2S,4R)-(4-hydroxyprolyl)glycyl-(S)-(3-(2-thienyl)alanyl)-(S)- seryl-(R)-((1,2,3,4-tetrahydro-3-isoquinolyl)carbonyl)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S)-arginine acetate (paakai); Icatibant acetate; L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3, 4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-, acetate (paakai)

  • inoa pake

  • Acetabant acetate; D - l-arginine base - L - arginine base - L - mālama ʻia ka ammonia acyl - (4 r) - 4 - hydroxy - L - mālama ʻia ka ammonia acyl sugar-based - 3 - (2 -) thiophene base - L - propylene ammonia acyl - L - siliki ammonia acyl - (3 r) - 1, 2, 3, 4 - eha hydrogen Chemicalbook - 3 - isoquinoline carbonyl - (as) 2 s, 3 e like me, 7-8 h - 1 h - indole -2-carbonyl-L-arginine acetate; Aitebant acetate (Aitebant acetate, HOE140); ACETATE; Aldeibant acetate
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