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  • Icatibant asetat cas 138614-30-9

Jul. 13, 2023 10:04 Bali menyang dhaptar

Icatibant asetat cas 138614-30-9



Icatibant asetat cas 138614-30-9

Icatibant Acetate minangka antagonis reseptor bradykinin B2, sing bisa digunakake kanggo nambani angioedema turun temurun.

sinau in vitro

Icatibant(10-30μM)potentiatesangiotensinIII, butnotangiotensinII(contractionmediatedbyangiotensinAT1receChemicalbookptors),lanLys-des-Arg9-bradykinin, butnotdes-Arg9-bradikinin(efek mediatedbythebradykininB1reseptor).

sinau ing vivo

Icatibant (10-30μM) potentiates angiotensin III, nanging ora angiotensin II (kontraksibyangiotensinAT1reseptor), lan Lys-des-Arg9-bradykinin, butnotdes-Arg9-bradykinin (efek mediatedbythebradykininB1reseptor). Model Hewan: Tikus wadon saka galur CBA/J(H-Chemicalbook2k).

Dosis: 0,06, 0,3, utawa 1,5 mg / kg.

Administrasi: administrasi subkutane kaping pindho saben dina.

Asil: Dawane tes paling gedhe yaiku 93.6±6.8mm kanthi dosis 1.5mg/kg lan 94.0±4.1mm kanthi dosis 0.3mg/kg, nuduhake efek pencegahan sing signifikan ing shortening.

Sifat Atebant asetat Kondisi panyimpenan -20°C kelarutan DMSO:65.0(MaxConc.mg/mL); 47.63 (MaxConc. MM) Etanol: 0.25 (MaxConc. MgChemicalbook/mL); 0.18 (MaxConc. MM) PBS (pH7.2): 10.0 (MaxConc. Mg/mL); 7.33(MaxConc.mM) Acrystallinesolid

CAS nomer 138614-30-9

Rumus molekul C59H89N19O13S.C2H4O2

Bobot molekul 1364.59 Nomer EINECS:-

Sifat fisikokimia saka Altybant acetate

Kapadhetan 1.6g/cm3

Rumus molekul C61H93N19O15S

Bobot molekul 1364,57000

Massa akurat 1363.68000

 

Icatibant asetat cas 138614-30-9

Icatibant Acetate minangka antagonis reseptor bradykinin B2, sing bisa digunakake kanggo nambani angioedema turun temurun.

  • alias Inggris

  • Icatibant acetate [USAN]; (R)-Arginyl-(S)-arginyl-(S)-prolyl-(2S,4R)-(4-hydroxyprolyl)glycyl-(S)-(3-(2-thienyl)alanyl)-(S)- seryl-(R)-((1,2,3,4-tetrahydro-3-isoquinolyl)karbonil)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S)-arginine acetate (uyah); Icatibant asetat; L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3, 4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-, asetat (garam)

  • alias Cina

  • Acetabant asetat; D - l-arginine basa - L - arginin basa - L - diawetake amonia asil - (4 r) - 4 - hidroksi - L - diawetake amonia asil gula basis - 3 - (2 -) thiophene basa - L - propylene amonia asil - L - sutra amonia asil - (3 r) - 1, 2, 3, 4 - papat hidrogen Chemicalbook - 3 - isoquinoline karbonil - (as) 2 s, 3 as, 7-8 h - 1 h - indole -2-karbonil-L-arginine asetat; Aitebant asetat (Aitebant asetat, HOE140); ASETAT; Aldeibant asetat
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