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Jul. 13, 2023 10:04 Komawa zuwa lissafi

Icatibant acetate cas 138614-30-9



Icatibant acetate cas 138614-30-9

Icatibant Acetate antagonist na bradykinin B2 mai karɓa, wanda za'a iya amfani dashi don maganin angioedema na gado.

in vitro karatu

Icatibant (10-30μM) potentiatesangiotensinIII, butnotangiotensinII (contractionmediatedbyangiotensinAT1receChemicalbookptors), da Lys-des-Arg9-bradykinin, butnotdes-Arg9-bradykinin (sakamako ta hanyar masu karɓa nabradykininB1).

in vivo karatu

Icatibant (10-30μM) yana ƙarfafa angiotensin III, amma ba angiotensinII (masu karɓa ba) da Lys-des-Arg9-bradykinin, butnotdes-Arg9-bradykinin (yana tasiri ta hanyar masu karɓa nabradykininB1). Model Dabbobi: Berayen mata na nau'in CBA/J(H-Chemicalbook2k).

Sashi: 0.06,0.3, ko 1.5mg/kg.

Gudanarwa: Gudanar da subcutaneous sau biyu a rana.

Sakamakon: Tsawon mafi girman inewas93.6 ± 6.8mm tare da 1.5mg/kg sashi da 94.0± 4.1mm tare da kashi 0.3mg/kg, yana nuna babban tasiri na rigakafi akan ragewa.

Atebant acetate Properties Yanayin ajiya -20 ° C solubility DMSO: 65.0 (MaxConc.mg/mL); 47.63 (MaxConc. MM) Ethanol: 0.25 (MaxConc. MgChemicalbook/mL); 0.18 (MaxConc. MM) PBS (pH7.2): 10.0 (MaxConc. Mg/mL); 7.33 (MaxConc.mM) Acrystallinesolid

Lambar CAS 138614-30-9

Tsarin kwayoyin halitta C59H89N19O13S.C2H4O2

Nauyin kwayoyin halitta 1364.59EINECS lambar: -

Abubuwan Physicochemical na Altybant acetate

Yawaita 1.6g/cm3

Tsarin kwayoyin halitta C61H93N19O15S

Nauyin kwayoyin 1364.57000

Daidaitaccen taro 1363.68000

 

Icatibant acetate cas 138614-30-9

Icatibant Acetate antagonist na bradykinin B2 mai karɓa, wanda za'a iya amfani dashi don maganin angioedema na gado.

  • turanci mai suna

  • Icatibant acetate [USAN]; (R) -Arginyl-(S) -arginyl-(S)-prolyl-(2S,4R)-(4-hydroxyprolyl) glycyl-(S)-(3- (2-thienyl) alanyl)-(S) seryl-(R)-((1,2,3,4-tetrahydro-3-isoquinolyl)carbonyl)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S) -arginine acetate (gishiri); Acatibant acetate; L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3- (2-thienyl)-L-alanyl-L-seryl-D-1,2,3, 4-tetrahydro-3-isoquinolinecarbonyl-L- (2alpha,3abeta,7abeta) -octahydro-1H-indole-2-carbonyl-, acetate (gishiri)

  • Lakabi na kasar Sin

  • Tsarin acetate; D - l-arginine tushe - L - arginine tushe - L - kiyaye ammonia acyl - (4 r) - 4 - hydroxy - L - kiyaye ammonia acyl sugar tushen - 3 - (2 -) thiophene tushe - L - propylene ammonia acyl - L - siliki ammonia acyl - (3 r) - 1, 2, 3, 4 - hydrogen hudu Chemicalbook - 3 - isoquinoline carbonyl - (as) 2 s, 3 as, 7-8 h - 1 h - indole -2-carbonyl-L-arginine acetate; Aitebant acetate (Aitebant acetate, HOE140); ACETA; Aldeibant acetate
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