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Jul . 13, 2023 10:04 Back to list

Icatibant acetate cas 138614-30-9



Icatibant acetate cas 138614-30-9

Icatibant Acetate inopikisa bradykinin B2 receptor, iyo inogona kushandiswa kurapa nhaka angioedema.

in vitro kudzidza

Icatibant(10-30μM) inogona kuitasangiotensinIII,asinotangiotensinII(contractionmediatedbyangiotensinAT1receChemicalbookptors),uyeLys-des-Arg9-bradykinin,butnotdes-Arg9-bradykinin(zvinoitwa nebradykininB1 zvinogamuchira).

mu vivo kudzidza

Icatibant (10-30μM) inopa angiotensin III, asi kwete angiotensinII(contractionmediatedbyangiotensinAT1receptors), uyeLys-des-Arg9-bradykinin, butnotdes-Arg9-bradykinin(zvinoitwa nebradykininB1receptors). Mhuka Muenzaniso:Mbeva dzechikadzi dzeCBA/J(H-Chemicalbook2k) strain.

Chiyero: 0.06,0.3, kana 1.5mg/kg.

Kutonga: Subcutaneous administration kaviri zuva nezuva.

Mhedzisiro:Kureba kwehukuru hwakakura inewas93.6±6.8mm ine1.5mg/kg dosage uye 94.0±4.1mm ine 0.3mg/kg dosage,ichiratidza kudzivirirwa kwakakosha pakupfupisa.

Atebant acetate properties Kuchengetedza mamiriro -20°C solubility DMSO:65.0(MaxConc.mg/mL); 47.63 (MaxConc. MM) Ethanol: 0.25 (MaxConc. MgChemicalbook/mL); 0.18 (MaxConc. MM) PBS (pH7.2) : 10.0 (MaxConc. Mg/mL); 7.33(MaxConc.mM) Acrystallineolid

Nhamba yeCAS 138614-30-9

Molecular formula C59H89N19O13S.C2H4O2

Molecular uremu 1364.59EINECS nhamba: -

Physicochemical properties yeAltybant acetate

Density 1.6g/cm3

Molecular formula C61H93N19O15S

Molecular uremu 1364.57000

Huru hwechokwadi 1363.68000

 

Icatibant acetate cas 138614-30-9

Icatibant Acetate inopikisa bradykinin B2 receptor, iyo inogona kushandiswa kurapa nhaka angioedema.

  • Chirungu alias

  • Icatibant acetate [USAN]; (R)-Arginyl-(S)-arginyl-(S)-prolyl-(2S,4R)-(4-hydroxyprolyl)glycyl-(S)-(3-(2-thienyl)alanyl)-(S)- seryl-(R)-((1,2,3,4-tetrahydro-3-isoquinolyl)carbonyl)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S)-arginine acetate (munyu); Icatibant acetate; L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3, 4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-, acetate (munyu)

  • Chinese alias

  • Acetabant acetate; D - l-arginine base - L - arginine base - L - yakachengetedzwa ammonia acyl - (4 r) - 4 - hydroxy - L - yakachengetedzwa ammonia acyl sugar-based - 3 - (2 -) thiophene base - L - propylene ammonia acyl L - silk ammonia acyl - (3 r) - 1, 2, 3, 4 - ina hydrogen Chemicalbook - 3 - isoquinoline carbonyl - (as) 2 s, 3 se, 7-8 h - 1 h - indole -2-carbonyl-L-arginine acetate; Aitebant acetate (Aitebant acetate,HOE140); ACETATE; Aldeibant acetate
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