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  • Icatibant asetat cas 138614-30-9

Iyul . 13, 2023 10:04 Roʻyxatga qaytish

Icatibant asetat cas 138614-30-9



Icatibant asetat cas 138614-30-9

Icatibant asetat bradikinin B2 retseptorlarining antagonisti bo'lib, irsiy anjiyoödemni davolash uchun ishlatilishi mumkin.

in vitro o'rganish

Icatibant (10-30 mkM) angiotensin III, butnotangiotensin II (angiotensin AT1 rece Chemicalbookptors tomonidan qisqarish vositasi) va Lys-des-Arg9-bradikinin, butnotdes-Arg9-bradikinin (tebradikinin B1 retseptorlari orqali ta'sir qiladi) kuchaytiradi.

in vivo tadqiqot

Icatibant (10-30 mkM) angiotensin III ni kuchaytiradi, ammo angiotensin II (angiotensinAT1 retseptorlari orqali qisqarish) va Lys-des-Arg9-bradikinin, butnotdes-Arg9-bradikinin (tebradikinin B1 retseptorlari orqali ta'sir qiladi) ni kuchaytirmaydi. Hayvon modeli: CBA/J(H-Chemicalbook2k) shtammining urg'ochi sichqonlari.

Dozaj: 0,06,0,3 yoki 1,5 mg/kg.

Qo'llash usuli: teri ostiga kuniga ikki marta.

Natija: Eng katta ichakning uzunligi 1,5 mg/kg dozada 93,6 ± 6,8 mm va 0,3 mg/kg dozada 94,0 ± 4,1 mm bo'lib, qisqarishga sezilarli profilaktik ta'sir ko'rsatadi.

Atebant asetat xossalari Saqlash sharoitlari -20°C eruvchanligi DMSO:65.0(MaxConc.mg/mL); 47,63 (MaxConc. MM) Etanol: 0,25 (MaxConc. MgChemicalbook/ml); 0,18 (MaxConc. MM) PBS (pH7,2): 10,0 (MaxConc. Mg/ml); 7.33 (Maks. Kons.mM) Akristalli qattiq

CAS raqami 138614-30-9

Molekulyar formula C59H89N19O13S.C2H4O2

Molekulyar og'irligi 1364.59EINECS raqami: -

Altibant asetatning fizik-kimyoviy xossalari

Zichlik 1,6 g/sm3

Molekulyar formula C61H93N19O15S

Molekulyar og'irligi 1364,57000

Aniq massa 1363,68000

 

Icatibant asetat cas 138614-30-9

Icatibant asetat bradikinin B2 retseptorlarining antagonisti bo'lib, irsiy anjiyoödemni davolash uchun ishlatilishi mumkin.

  • Ingliz taxallus

  • Icatibant asetat [USAN]; (R) -Arginil-(S)-arginil-(S)-prolil-(2S,4R)-(4-gidroksiprolil)glisil-(S)-(3-(2-tienil)alanil)-(S)- seril-(R)-((1,2,3,4-tetrahidro-3-izokinolil)karbonil)-(2S,3aS,7aS)-((geksahidro-2-indolinil)karbonil)-(S)-arginin asetat (tuz); Icatibant asetat; L-Arginin, D-arginil-L-arginil-L-prolil-trans-4-gidroksi-L-prolilglitsil-3-(2-tienil)-L-alanil-L-seril-D-1,2,3, 4-tetrahidro-3-izokinolinkarbonil-L-(2alfa,3abeta,7abeta)-oktahidro-1H-indol-2-karbonil-, asetat (tuz)

  • Xitoy taxalluslari

  • Asetabant asetat; D - l-arginin asosi - L - arginin asosi - L - konservalangan ammiak asil - (4 r) - 4 - gidroksi - L - konservalangan ammiak asil shakar asosida - 3 - (2 -) tiofen asosi - L - propilen ammiak asil - L - ipak ammiak asil - (3 r) - 1, 2, 3, 4 - to'rtta vodorod Kimyoviy kitob - 3 - izokinolin karbonil - (as) 2 s, 3 as, 7-8 soat - 1 soat - indol -2-karbonil-L-arginin asetat; Aitebant asetat (Aitebant asetat, HOE140); ASETAT; Aldeibant asetat
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