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Aug. 03, 2023 09:27 Hoʻi i ka papa inoa

MOG (35-55) CAS 149635-73-4 ma ke kumu kūʻai nui



MOG (35-55) CAS 149635-73-4 ma ke kumu kūʻai nui

ʻO ka myelin oligodendrocytes glycoprotein (myelinoligodendrocyteglyco - protein, MOG) he ʻōnaehana nūnū waena (centralnervoussystem, CNS) myelin outermost content minimal myelin protein composition, He subtype o immunoglobulin IgG1, ka mea e hoʻoponopono pono i ka cytotoxicity hilinaʻi complement a he mea nui o ka puke kemika. - hoʻokomo ʻia ka demyelination o MS. He kuleana koʻikoʻi ka MOG antibody resistance in multiple sclerosis (multiplesclerosis, MS) i ke kaʻina hana pathological, i hoʻoulu ʻia e MOG hoʻokolohua autoimmune encephalomyelitis (experimentalautoimmuneencephalomyelitis, EAE he kumu hoʻohālike holoholona i ʻike ʻia ma ka honua o MS.

'Ano 1. Adhesion mole OG immunoglobuloin-like wahi like me butyrophilin wahi like, a me ka moa BG antigen hiki ole ike MOG hana. ʻO ka ʻike ʻana o ka ʻili o MOG, ka ʻike ʻana i nā MOG ma ke ʻano he immunoglobulin superfamily, a me ke ʻano o ka Lα/HNK-1 carbohydrate antigen epitopes e kākoʻo i ka hana o MOG ma ke ʻano he mole adhesion a i ʻole nā ​​​​mea hoʻokipa cell. Ua loaʻa iā ia ma ka alpha/HNK L - 1 antigen epitope i ʻike ʻia ʻo ka myelin pili glycoprotein (myelin - associated glycoprotein, MAG) a me P0, loaʻa iā lāua ka ʻāpana adhesion o ka myelin protein specificity. Inā loaʻa i ka MOG kahi hana adhesion, hiki ke hoʻopili ʻia me nā mea ʻē aʻe o ke kikowaena pūnaewele ʻē aʻe; Manaʻo ʻia inā he koʻikoʻi ko MOG i ka hoʻopili ʻana i ke kelepona, hiki ke hana ʻo MOG ma ke ʻano he "glue" i hoʻopili ʻia ma waena o nā fiber myelin e pili ana a hiki ma hope o ke kaʻina hana myelination. 2. Hiki i ka microtubule stable regulator 8-18C5 antibody ke hoʻohaʻahaʻa i ka MBP i loko o ka puʻu myelin maʻemaʻe. 3. E ho'ā i ka hoʻokō MOG genes i ka nui histocompatibility complex (MHC) majorhistocompatibilitChemicalbookycomplex, kahi o ka mea like me ka moa MHC antigen B - G, ua like kona ʻano me nā ʻohana gene, hiki ke hana i ka pane immune ikaika. Manaʻo ʻia ʻo MOG he hana pale i loko o ka ʻōnaehana nerve waena, a ʻo nā hōʻike mua i hōʻike ʻia e hōʻike ʻia ka MOG i nā ʻano neutrophils, e kākoʻo pū ana i ka hana immune o MOG. ʻOiai ʻaʻole ʻo MOG i loko o nā ʻano mea hānai ʻole o ka myelin, hiki ke wehewehe ʻia ma nā ʻano he nui. Hoʻokahi wehewehe ʻana ʻaʻole hana pololei ʻo MOG i nā kaʻina myelin, a ʻoi aku ka pololei, hiki ke hoʻopili i ka myelin a me nā kaʻina hana ʻē aʻe i loko o vivo Hoʻokahi mea, e like me ka pilina ma waena o ka ʻōnaehana immune; ʻO kekahi wehewehe ʻana, ʻo MOG ka mea kikoʻī i ka hana immune o ka CNS myelin sheath, ʻaʻole like me ka ʻōnaehana nūnū ʻo myelin sheath, ka mea e hoʻāla ai i ke ala hoʻohui maʻamau i vivo. ʻO ka pale ʻana i ka maʻi maʻi DNA pale MOG (MOG) - hiki i ka DNA ke pale i nā ʻiole me ka hoʻokolohua autoimmune encephalomyelitis (EAE experimentalautoimmuneencephalomyelitis), ma o ke kuleana o ka hoʻokō C3d. No laila, pono i loko o ka CNS myelin sheath nā mea hoʻohui e hoʻopaʻa iā Ctq, e alakaʻi ana i ka hoʻokō ʻana.

 

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