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Aug. 03, 2023 09:27 Bwererani ku mndandanda

MOG (35-55) CAS 149635-73-4 pamtengo wamba



MOG (35-55) CAS 149635-73-4 pamtengo wamba

Myelin oligodendrocytes glycoprotein (myelinoligodendrocyteglyco - protein, MOG) ndi chapakati mantha dongosolo (centralnervoussystem, CNS) myelin zakunja zili zochepa myelin mapuloteni kapangidwe, Ndi subtype wa immunoglobulin IgG1, amene bwino amawongolera complement-amadalira cytotoxicity complementity -kuchepetsa kuchepa kwa MS. MOG antibody resistance mu multiple sclerosis (multiplesclerosis, MS) imakhala ndi gawo lofunika kwambiri pa ndondomeko ya pathological, yoyambitsidwa ndi MOG experimental autoimmune encephalomyelitis (experimentalautoimmuneencephalomyelitis, EAE ndi nyama yodziwika padziko lonse ya MS.

Makhalidwe 1. Adhesion molekyulu OG immunoglobuloin-ngati dera ndi ofanana ndi butyrophilin dera ofanana, ndi nkhuku BG antigen sangathe kuzindikira MOG ntchito. Mawonekedwe amtundu wa MOGs, kuzindikira kwa MOGs monga immunoglobulin superfamily, ndi maonekedwe a Lα / HNK-1 carbohydrate antigen epitopes onse amathandizira ntchito ya MOGs monga mamolekyu omatira kapena ma cell receptors. Anapeza pa alpha / HNK L - 1 antigen epitope adadziwika kuti myelin yogwirizana ndi glycoprotein (myelin - yogwirizana ndi glycoprotein, MAG) ndi P0, onsewa ali ndi chigawo chotsatira cha mapuloteni a myelin. Ngati MOG ili ndi ntchito yomatira, ikhoza kukumana ndi zigawo zina zapakati pa mitsempha pambali payokha; Zimaganiziridwa kuti ngati MOG ili ndi gawo lalikulu pakumatira kwa ma cell, MOG imatha kukhala ngati zomatira "glue" pakati pa ulusi wa myelin woyandikana ndipo zimachitika pambuyo pake m'miyendo. 2. Microtubule stable regulator 8-18C5 antibody ingayambitse kuwonongeka kwa MBP mu sheath yoyeretsedwa ya myelin. 3. Yambitsani complement complement MOG genes in major histocompatibility complex (MHC) majorhistocompatibilitChemicalbookycomplex, malo ofanana ndi nkhuku MHC antigen B - G, kapangidwe kake ndi ofanana ndi mabanja jini, zingachititse amphamvu chitetezo cha m'thupi. MOG imaganiziridwa kuti ili ndi chitetezo chamthupi m'kati mwa mitsempha yapakati, ndipo malipoti oyambirira oyambirira amasonyeza kuti MOG imasonyezedwa mu mitundu yambiri ya neutrophils, yomwe imathandizanso chitetezo cha mthupi cha MOG. Ngakhale kuti MOG palibe mu mitundu yosadyetsa ya myelin, ikhoza kufotokozedwa m'njira zingapo. Kufotokozera kumodzi ndikuti MOG sichichita mwachindunji pamayendedwe a myelin, ndipo molondola, imatha kuyimira myelin ndi njira zina mu vivo. Chigawo chimodzi, monga kukhudzana pakati pa chitetezo cha mthupi; Kufotokozera kwina ndikuti MOG ndi yodziwikiratu ku chitetezo chamthupi cha CNS myelin sheath, mosiyana ndi zotumphukira zamanjenje myelin sheath, yomwe imayambitsa njira yachikale yothandizira mu vivo. Katemera wa Protective DNA encoding MOG (MOG) - DNA ingalepheretse mbewa zoyeserera zoyeserera za autoimmune encephalomyelitis (EAE experimentalautoimmuneencephalomyelitis), kudzera mu gawo lothandizira kukhazikitsa C3d. Choncho, CNS myelin sheath iyenera kukhala ndi zigawo zowonjezera zomwe zimamangiriza Ctq, zomwe zimatsogolera kutsegulira kowonjezera.

 

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