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Aug. 03, 2023 09:27 Hoki ki te rarangi

MOG (35-55) CAS 149635-73-4 i te utu hokohoko



MOG (35-55) CAS 149635-73-4 i te utu hokohoko

Ko te myelin oligodendrocytes glycoprotein (myelinoligodendrocyteglyco - pūmua, MOG) he punaha nerve pokapū (centralnervoussystem, CNS) myelin o waho te ihirangi te iti o te hanganga pūmua myelin, He momo iti o te immunoglobulin IgG1, e whakahaere tika ana i te cytotoxicity e whakawhirinaki ana ki te whakakii me te waahanga matua o te pukapuka matū. -te whakahekenga o MS. Ko te parenga antibody MOG i roto i te sclerosis maha (multiplesclerosis, MS) he mahi tino nui i roto i te tukanga pathological, i whakaawehia e te MOG whakamatautau autoimmune encephalomyelitis (experimentalautoimmuneencephalomyelitis, EAE he tauira kararehe e mohiotia ana i te ao o MS.

Nga Ahuatanga 1. He rite te ngota ngota adhesion OG immunoglobuloin-rite ki te rohe rite te butyrophilin, a kaore e taea e te heihei BG antigen te mohio ki te mahi MOG. Ko te waahi o te mata o MOGs, ko te mohiotanga o nga MOG hei immunoglobulin superfamily, me te ahua o te Lα / HNK-1 carbohydrate antigen epitopes e tautoko katoa ana i te mahi a nga MOG hei ngongo ngota adhesion, he kaiwhakawhiwhi pūtau ranei. I kitea e ia i runga i te alpha/HNK L - 1 antigen epitope i tohuhia ko te myelin associated glycoprotein (myelin - associatedglycoprotein, MAG) me te P0, kei a raua te wahanga piri o te mielin pūmua motuhake. Mēnā he adhesion te mahi a te MOG, tērā pea ka whakapā atu ki ētahi atu wāhanga o te pūnaha io i tua atu i a ia ano; E whakapaetia ana mena he whai waahi nui a MOG ki te whakapiringa o te pūtau, ka mahi pea a MOG hei "kapia" i waenga i nga muka myelin e tata ana, ka puta i muri mai i te tukanga myelination. 2. Microtubule stable regulator 8-18C5 antibody taea meinga MBP degradation i roto i pure myelin sheath. 3. Whakahohehia te whakakii i nga ira MOG i roto i te matatini histocompatibility nui (MHC) majorhistocompatibilitChemicalbookycomplex, te waahi o te taua rite te heihei MHC antigen B - G, he rite tona hanganga ki nga whanau ira, ka taea te kaha te urupare mate. E whakapaetia ana he mahi aukati a MOG i roto i te punaha nerve matua, a ko nga purongo o mua tata nei e kii ana kei te whakaatuhia te MOG i roto i te whānuitanga o nga neutrophils, e tautoko ana hoki i te mahi aukati a MOG. Ahakoa karekau a MOG i roto i nga momo myelin kore whangai, ka taea te whakamarama i nga huarahi maha. Ko tetahi whakamarama ko te MOG karekau e mahi tika i runga i nga mahi myelin, me te tika ake, tera pea ka takawaenga i te myelin me etahi atu tukanga in vivo Ko tetahi waahanga, penei i te whakapiri i waenga i te punaha mate; Ko tetahi atu whakamaarama ko te MOG he mea motuhake ki te mahi aukati o te CNS myelin sheath, kaore i rite ki te pukoro myelin system nerve peripheral, e whakahohe ana i te ara taapiri puāwaitanga i roto i te vivo. Ko te whakawaehere kano kano DNA tiaki MOG (MOG) - Ka taea e te DNA te aukati i nga kiore me te whakamaaramatanga autoimmune encephalomyelitis (EAE experimentalautoimmuneencephalomyelitis), na roto i te mahi ki te whakakii i te whakatinanatanga C3d. Na reira, me whakauru i roto i te pukoro myelin CNS nga waahanga taapiri e herea ana a Ctq, e arahi ana ki te whakakii i te whakahohenga.

 

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