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Aok. 03, 2023 09:27 Toe fo'i i le lisi

MOG (35-55) CAS 149635-73-4 i le tau faʻatau



MOG (35-55) CAS 149635-73-4 i le tau faʻatau

Myelin oligodendrocytes glycoprotein (myelinoligodendrocyteglyco - porotini, MOG) o se faiga neura tutotonu (centralnervoussystem, CNS) myelin pito pito i fafo mea itiiti myelin porotini fatuga, O se subtype o immunoglobulin IgG1, lea e faatonutonuina lelei atoatoa-faalagolago cytotoxicity ma o se vaega autu o tusi kemisi. - fa'aosoina le demyelination o MS. MOG antibody resistance i le tele sclerosis (multiplesclerosis, MS) e taua tele i le faagasologa o pathological, faʻaosoina e le MOG faʻataʻitaʻiga autoimmune encephalomyelitis (experimentalautoimmuneencephalomyelitis, EAE o se faʻataʻitaʻiga manu faʻavaomalo o MS.

Uiga 1. Adhesion mole OG immunoglobuloin-pei o le itulagi e tutusa ma le butyrophilin itulagi tutusa, ma moa BG antigen le mafai ona iloa MOG galuega. O le faʻaogaina o le MOGs, o le faʻalauiloaina o MOG e pei o le immunoglobulin superfamily, ma le faʻaalia o le Lα / HNK-1 carbohydrate antigen epitopes e lagolagoina uma le galuega a MOG e pei o mole mole faʻapipiʻi poʻo le faʻaogaina o sela. Na ia mauaina i luga o le alpha / HNK L - 1 antigen epitope na faailoaina o le myelin associated glycoprotein (myelin - associated glycoprotein, MAG) ma le P0, o loʻo i ai uma le vaega pipii o le myelin protein specificity. Afai ole MOG o loʻo i ai le faʻaogaina o galuega, e mafai ona faʻafesoʻotaʻi ma isi vaega o le neura tutotonu e ese mai ia te ia; O loʻo faʻapea e iai se sao taua a le MOG i le faʻapipiʻiina o sela, e mafai e le MOG ona galue o se "kelu" faʻapipiʻi i le va o filo myelin lata ane ma tupu mulimuli ane i le faagasologa o le myelination. 2. Microtubule stable regulator 8-18C5 antibody e mafai ona mafua ai le faʻaleagaina o le MBP ile faʻamamāina myelin sheath. 3. Fa'aagaoioia fa'ameamea MOG genes i le tele histocompatibility complex (MHC) majorhistocompatibilitChemicalbookycomplex, o le nofoaga o le tutusa ma le moa MHC antigen B - G, o lona fausaga e tutusa ma gene aiga, e mafai ona mafua ai le malosi tali puipuia. MOG o loʻo faʻamoemoeina e iai se puipuiga i totonu o le fatugalemu o le tino, ma o lipoti muamua talu ai nei o loʻo faʻaalia ai le MOG o loʻo faʻaalia i le tele o neutrophils, lea e lagolagoina ai le puipuiga o le MOG. E ui lava e le o iai le MOG i ituaiga e le fafagaina o myelin, e mafai ona faʻamatalaina i le tele o auala. O le tasi faʻamatalaga o le MOG e le faʻaogaina saʻo i luga o le myelin, ma sili atu le saʻo, e mafai ona faʻatalanoaina myelin ma isi gaioiga i vivo Tasi vaega, e pei o feso'ota'iga i le va o le puipuiga; O le isi faʻamatalaga o le MOG e faʻapitoa i le puipuiga o le CNS myelin sheath, e le pei o le peripheral nervous system myelin sheath, lea e faʻagaoioia ai le auala faʻapitoa i vivo. Puipuia DNA tui fa'ailoga MOG (MOG) - DNA e mafai ona puipuia isumu fa'ata'ita'i autoimmune encephalomyelitis (EAE experimentalautoimmuneencephalomyelitis), e ala i le matafaioi o le fa'atutusa C3d fa'atinoga. O le mea lea, o le CNS myelin sheath e tatau ona aofia ai vaega faʻapipiʻi e fusifusia Ctq, e taʻitaʻia ai le faʻamalosia o le faʻagaoioia.

 

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