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Aug. 03, 2023 09:27 Back to list

MOG (35-55) CAS 149635-73-4 pamutengo wekutengesa



MOG (35-55) CAS 149635-73-4 pamutengo wekutengesa

Myelin oligodendrocytes glycoprotein (myelinoligodendrocyteglyco - protein, MOG) ndeyepakati tsinga sisitimu (centralnervoussystem, CNS) myelin ekunze zvemukati mashoma myelin protein kuumbwa, Iyo iine subtype ye immunoglobulin IgG1, iyo inogadzirisa zvinobudirira inopindirana-inoenderana nekemikari inoenderana neiyo cytotoxicity. -induced demyelination yeMS. MOG antibody resistance mumultiple sclerosis (multiplesclerosis, MS) inoita basa rakakosha zvikuru muhurongwa hwepathological, hunokonzerwa neMOG experimental autoimmune encephalomyelitis (experimentalautoimmuneencephalomyelitis, EAE imhando yemhuka inozivikanwa pasi rose yeMS.

Hunhu 1. Adhesion molecule OG immunoglobuloin-like region yakafanana nebutyrophilin yakafanana nharaunda, uye huku BG antigen haigoni kuziva MOG basa. Nzvimbo yepamusoro yeMOGs, kuzivikanwa kweMOGs se immunoglobulin superfamily, uye kuonekwa kweLα / HNK-1 carbohydrate antigen epitopes zvose zvinotsigira basa reMOGs semamolekemu ekunamatira kana cell receptors. Akawana pane alpha / HNK L - 1 antigen epitope yakaonekwa se myelin inobatanidza glycoprotein (myelin - associatedglycoprotein, MAG) uye P0, zvose zvine chikamu chekunamatira chemyelin protein. Kana MOG iine adhesion function, inogona kusangana nedzimwe nhengo dzepakati tsinga kunze kwayo; Zvinofungidzirwa kuti kana MOG ine basa rakakosha mukunamira kwesero, MOG inogona kuita seyakanamatira "glue" pakati pepedyo myelin fibers uye inoitika gare gare mumyelination process. 2. Microtubule stable regulator 8-18C5 antibody inogona kukonzera kukanganisa kweMBP mukucheneswa myelin sheath. 3. Activate complement MOG genes in major histocompatibility complex (MHC) majorhistocompatibilitChemicalbookycomplex, nzvimbo yakafanana nehuku MHC antigen B - G, chimiro chayo chakafanana nemhuri dzejeni, zvinogona kukonzera simba rekudzivirira zvirwere. MOG inofungidzirwa kuva nehutachiona hwehutachiona mukati mehutano hwemagetsi, uye mishumo yemazuva ano yekutanga inoratidza kuti MOG inoratidzirwa muhuwandu hwema neutrophils, iyo inotsigirawo maitiro ezvirwere zveMOG. Kunyange zvazvo MOG isipo mumhando dzisina kudya dzemyelin, inogona kutsanangurwa nenzira dzakawanda. Imwe tsananguro ndeyokuti MOG haiiti zvakananga pane myelin maitiro, uye zvakanyanya, inogona kupindirana myelin nemamwe maitiro mu vivo. Chimwe chikamu, sekusangana pakati pesimba remuviri wemuviri; Imwe tsananguro ndeyokuti MOG yakanangana neiyo immune system yeCNS myelin sheath, kusiyana neyeperipheral nervous system myelin sheath, iyo inomisa yekirasi yekuwedzera nzira mu vivo. Dziviriro yeDNA vaccine encoding MOG (MOG) - DNA inogona kudzivirira mbeva nekuyedza autoimmune encephalomyelitis (EAE experimentalautoimmuneencephalomyelitis), iri kuburikidza nebasa rekuzadzisa C3d kuita. Naizvozvo, iyo CNS myelin sheath inofanirwa kunge iine zvinhu zvinopindirana zvinosunga Ctq, zvichitungamira kuzadzisa activation.

 

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