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Aug . 03, 2023 09:27 Ad album

MOG (35-55) CAS 149635-73-4



MOG (35-55) CAS 149635-73-4

Myelin oligodendrocytes glycoprotein (myelinoligodendrocyteglyco - interdum, MOG) systema nervosum centrale (centralnervoussystem, CNS) myelini extimum contentum compositionis dapibus minimi myelini, Subtypum immunoglobulin IgG1 est, quod efficaciter cytotoxicitatis chemicae complementum regit et est. inducta demyelination of MS. MOG anticorpus resistentia in multiplex sclerosis (multiplesclerosis, MS) munus in processu pathologico maximis agit, adductum per MOG experimentalem autoimmune encephalomyelitis (experimentalautoimmuneencephalomyelitis, EAE exemplar animalis internationale agnitum MS.

Characteres 1. Adhaesio moleculo OG immunoglobuloin-similis regioni similis est cum butyrophilino similis regioni, et pullus BG antigen munus MOG agnoscere non potest. Superficies localizationis MOGs, agnitio MOGs ut immunoglobulin superfamilia, et species Lα/HNK-1 epitopi carbohydratorum antigenorum omnes sustinent munus MOGs ut adhaesio molecularum vel receptaculorum cellularum. Invenit in alpha/HNK L - 1 epitopae antigenis notata sunt cum myelin glycoprotein consociata (myelin - consociataglycoprotein, MAG) et P0, utrumque elementum myelini dapibus speciei adhaesio habet. Si MOG munus adhaesionem habet, attingere potest cum aliis systematis nervorum centralibus praeter se; Existimatur MOG si munus insignem habeat in adhaesione cellae, MOG agere ut inter fibras myelin adjacentes adiacentes "glutines" et postea in processu myelinationis contingat. 2. Microtubula stabilis moderatrix 8-18C5 anticorpus degradationem MBP in vaginam myelini purificatam causare potest. 3. Complementum activum MOG genes in histocompatibilitate maiore complexu (MHC) majorhistocompatibilitChemicalbookycomplex, situm eiusdem cum pullo MHC antigen B - G, eius structura similis familiae gene, responsionem immunem validam causare potest. MOG hypothesizatur ut munus immune in systemate nervosi centrali habeat, et recentes relationes praeliminares suadeant MOG in amplis neutrophils exprimi, quae etiam munus immune MOG sustinet. Etsi MOG in speciebus myelini non pascentibus non adest, multipliciter explicari potest. Una explicatio est, quod MOG in myelin processibus directe non agit, et rectius potest myelin et alios processus in vivo mediare. Una pars, ut contactu inter immunes; Alia explicatio est MOG respective specificum ad functionem immunem vaginae CNS myelin, dissimilis systematis nervosi peripherici vaginae myelini, quae viam complet classicam in vivo. Tutela DNA vaccinum descriptam MOG (MOG) - DNA mures experimentali autoimmune encephalomyelitis prohibere potest (EAE experimentalautoimmuneencephalomyelitis), per partes exsecutionis C3d complementi. Ergo vagina CNS myelin debet continere elementa complementaria quae ligant Ctq, ducens ad activationem completivam.

 

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