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  • MOG (35-55) CAS 149635-73-4 na ọnụ ahịa ọnụ ahịa

Ọgọst. 03, 2023 09:27 Laghachi na ndepụta

MOG (35-55) CAS 149635-73-4 na ọnụ ahịa ọnụ ahịa



MOG (35-55) CAS 149635-73-4 na ọnụ ahịa ọnụ ahịa

Myelin oligodendrocytes glycoprotein (myenoligodendrocyteglyco-protein, MOG) bụ sistemu ụjọ nke etiti (centralnervoussystem, CNS) myelin outermost ọdịnaya kacha nta nke protein myelin, Ọ bụ ụdị nke immunoglobulin IgG1, nke na-achịkwa nke ọma cytotoxicity na-adabere na ya. -akpata demyelination nke MS. Mgbochi mgbochi MOG na otutu sclerosis (multiplesclerosis, MS) na-arụ ọrụ dị oke mkpa na usoro pathological, nke MOG nnwale autoimmune encephalomyelitis kpatara (experimentalautoimmuneencephalomyelitis, EAE bụ ụdị anụmanụ ama ama nke MS.

Njirimara 1. Adhesion molecule OG immunoglobuloin-dị ka mpaghara butyrophilin yiri mpaghara, na ọkụkọ BG antigen enweghị ike ịmata ọrụ MOG. Mkpokọta elu nke MOGs, nnabata nke MOG dị ka immunoglobulin superfamily, na ọdịdị nke Lα/HNK-1 carbohydrate antigen epitopes niile na-akwado ọrụ MOG dị ka molekul adhesion ma ọ bụ ndị na-anabata sel. Ọ chọtara na alfa/HNK L-1 antigen epitope ka amatara dị ka myelin metụtara glycoprotein (myelin - metụtara glycoprotein, MAG) na P0, ha abụọ nwere akụkụ adhesion nke myelin protein kpọmkwem. Ọ bụrụ na MOG nwere adhesion ọrụ, ọ nwere ike na-abịa na kọntaktị na ndị ọzọ Central ụjọ usoro components ma e wezụga onwe ya; A na-eche na ọ bụrụ na MOG nwere ọrụ dị ịrịba ama na adhesion cell, MOG nwere ike ịrụ ọrụ dị ka "glue" nrapado n'etiti eriri myelin dị n'akụkụ ma mee emesịa na usoro myelination. 2. Microtubule stable regulator 8-18C5 antibody nwere ike ime ka MBP mebiri emebi n'ọbọ myelin dị ọcha. 3. Mee mmeju MOG mkpụrụ ndụ ihe nketa na isi histocompatibility mgbagwoju (MHC) majorhistocompatibilitChemicalbookycomplex, ọnọdụ nke otu ihe ahụ dị ka ọkụkọ MHC antigen B - G, ya Ọdịdị bụ yiri gene ezinụlọ, nwere ike ime ka ike dịghịzi nzaghachi. A na-eche MOG ka ọ nwee ọrụ mgbochi na usoro nhụjuanya nke etiti, na akụkọ mmalite na-adịbeghị anya na-egosi na MOG na-egosipụta n'ọtụtụ neutrophils, nke na-akwadokwa ọrụ mgbochi nke MOG. Ọ bụ ezie na MOG adịghị na ụdị myelin na-adịghị eri nri, a pụrụ ịkọwa ya n'ọtụtụ ụzọ. Otu nkọwa bụ na MOG anaghị eme ihe ozugbo na usoro myelin, yana n'ụzọ ziri ezi, ọ nwere ike ịgbazite myelin na usoro ndị ọzọ na vivo. Otu akụkụ, dị ka kọntaktị n'etiti usoro ahụ ji alụso ọrịa ọgụ; Nkọwa ọzọ bụ na MOG bụ kpọmkwem maka ọrụ mgbochi nke CNS myelin sheath, n'adịghị ka sistemụ akwara myelin, nke na-eme ka ụzọ mmeju oge gboo na vivo. Mgbochi DNA na-echekwa MOG (MOG) - DNA nwere ike igbochi ụmụ oke nwere encephalomyelitis autoimmune autoimmune (EAE experimentalautoimmuneencephalomyelitis), bụ site na ọrụ mmeju mmejuputa C3d. Ya mere, n'ọbọ myelin CNS ga-enwerịrị ihe mgbakwunye na-ejikọta Ctq, na-eduga na mmeju mmeju.

 

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