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Kanama. 03, 2023 09:27 Subira kurutonde

MOG (35-55) CAS 149635-73-4 ku giciro cyinshi



MOG (35-55) CAS 149635-73-4 ku giciro cyinshi

Myelin oligodendrocytes glycoprotein (myelinoligodendrocyteglyco - protein, MOG) ni sisitemu yo hagati yo hagati (centralnervoussystem, CNS) myelin yo hanze cyane ya poroteyine ntoya ya myelin, Ni ubwoko bwa immunoglobuline IgG1, butunganya neza imiti ya cytotoxicitike kandi ni ikintu cy'ingenzi cya cytotoxicity -yatewe na demyelination ya MS. Kurwanya antibody ya MOG muri sclerose nyinshi (multiplesclerose, MS) igira uruhare runini mugikorwa cyindwara ya pathologiya, iterwa na MOG igerageza autoimmune encephalomyelitis (экспериментalautoimmuneencephalomyelitis, EAE nicyitegererezo cyinyamanswa kizwi ku rwego mpuzamahanga cya MS.

Ibiranga 1. molekules ya Adhesion OG immunoglobuloin isa nakarere ka butyrophiline, kandi antigen yinkoko BG ntishobora kumenya imikorere ya MOG. Ubuso bwaho bwa MOGs, kumenyekanisha MOGs nka immunoglobuline birenze urugero, no kugaragara kwa Lα / HNK-1 karubone ya antigen epitopes byose bishyigikira imikorere ya MOGs nka molekules ya adhesion cyangwa reseptor selile. Yasanze kuri alpha / HNK L - 1 antigen epitope yamenyekanye nka myelin ifitanye isano na glycoproteine ​​(myelin - associatedglycoprotein, MAG) na P0, byombi bifite ibice bifatika bya poroteyine ya myelin. Niba MOG ifite imikorere yo gufatira hamwe, irashobora guhura nibindi bice bigize sisitemu yo hagati ya sisitemu usibye ubwayo; Bikekwa ko niba MOG ifite uruhare runini muguhuza ingirabuzimafatizo, MOG irashobora gukora nka "kole" ifata fibre yegeranye na myelin hanyuma ikaza kubaho nyuma ya myelination. 2. Microtubule itunganya neza 8-18C5 antibody irashobora gutera MBP kwangirika mubyatsi bya myelin isukuye. 3. Kora ibyuzuzanya bya MOG mubice bikomeye bya histocompatibilité complex (MHC) majorhistocompatibilitChemicalbookycomplex, aho biherereye kimwe ninkoko MHC antigen B - G, imiterere yayo isa nimiryango ya gene, irashobora gutera ubudahangarwa bw'umubiri. MOG ikekwa kuba ifite imikorere yubudahangarwa muri sisitemu yo hagati y’imitsi, kandi raporo ziheruka zerekana ko MOG igaragarira mu bice bitandukanye bya neutrophile, nayo ishyigikira imikorere y’ubudahangarwa bwa MOG. Nubwo MOG idahari mubwoko butagaburira myelin, birashobora gusobanurwa muburyo butandukanye. Igisobanuro kimwe nuko MOG idakora muburyo butaziguye inzira ya myelin, kandi neza, irashobora guhuza myelin nibindi bikorwa muri vivo Ikintu kimwe, nko guhuza sisitemu yumubiri; Ikindi gisobanuro nuko MOG isa cyane cyane mumikorere yubudahangarwa bwumubyimba wa CNS myelin, bitandukanye na sisitemu ya periferique nervice myelin sheath, ikora inzira yuzuye yo kuzuzanya muri vivo. Urukingo rwa ADN rukingira kodegisi MOG (MOG) - ADN irashobora gukumira imbeba zifite igeragezwa rya autoimmune encephalomyelitis (EAE экспериментalautoimmuneencephalomyelitis), binyuze mu nshingano zo kuzuza C3d ishyirwa mu bikorwa. Kubwibyo, CNS myelin sheath igomba kuba irimo ibice byuzuzanya bihuza Ctq, biganisha ku kuzuza ibikorwa.

 

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