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  • MOG (35-55) CAS 149635-73-4 ntawm tus nqi lag luam wholesale

Aug. Peb 03, 2023 09:27 Rov qab mus rau npe

MOG (35-55) CAS 149635-73-4 ntawm tus nqi lag luam wholesale



MOG (35-55) CAS 149635-73-4 ntawm tus nqi lag luam wholesale

Myelin oligodendrocytes glycoprotein (myelinoligodendrocyteglyco - protein, MOG) yog lub hauv nruab nrab paj hlwb (centralnervoussystem, CNS) myelin sab nraud cov ntsiab lus tsawg kawg nkaus myelin protein muaj pes tsawg leeg, Nws yog ib qho subtype ntawm immunoglobulin IgG1, uas muaj txiaj ntsig zoo nyob rau hauv cov tshuaj lom neeg cov ntsiab lus tseem ceeb ntawm cov tshuaj lom neeg thiab tshuaj lom neeg. -induced demyelination ntawm MS. MOG antibody tiv thaiv nyob rau hauv ntau yam sclerosis (multiplesclerosis, MS) plays lub luag hauj lwm tseem ceeb heev nyob rau hauv cov txheej txheem pathological, induced los ntawm MOG sim autoimmune encephalomyelitis (experimentalautoimmuneencephalomyelitis, EAE yog ib tug thoob ntiaj teb lees paub tsiaj qauv ntawm MS.

Cov yam ntxwv 1. Adhesion molecule OG immunoglobuloin-zoo li thaj tsam zoo ib yam li thaj tsam butyrophilin, thiab nqaij qaib BG antigen tsis tuaj yeem paub txog MOG muaj nuj nqi. Qhov chaw hauv cheeb tsam ntawm MOGs, kev lees paub ntawm MOGs li immunoglobulin superfamily, thiab cov tsos ntawm Lα / HNK-1 carbohydrate antigen epitopes tag nrho txhawb kev ua haujlwm ntawm MOGs li adhesion molecules lossis cell receptors. Nws pom ntawm alpha / HNK L - 1 antigen epitope tau txheeb xyuas tias yog myelin txuam glycoprotein (myelin - txuam glycoprotein, MAG) thiab P0, ob leeg muaj qhov adhesion tivthaiv ntawm myelin protein tshwj xeeb. Yog hais tias MOG muaj adhesion muaj nuj nqi, nws yuav tuaj mus rau hauv kev sib cuag nrog lwm yam central paj hlwb Cheebtsam ntawm nws tus kheej; Nws tau kwv yees tias yog MOG muaj lub luag haujlwm tseem ceeb hauv kev ua kom cov cell adhesion, MOG tuaj yeem ua cov nplaum "cov kua nplaum" ntawm cov kab mob myelin uas nyob ib sab thiab tshwm sim tom qab hauv cov txheej txheem myelination. 2. Microtubule ruaj khov regulator 8-18C5 antibody tuaj yeem ua rau MBP degradation hauv purified myelin sheath. 3. Ua kom ntxiv dag zog MOG cov noob nyob rau hauv loj histocompatibility complex (MHC) majorhistocompatibilitChemicalbookycomplex, qhov chaw ntawm tib yam li nqaij qaib MHC antigen B - G, nws cov qauv zoo ib yam li cov tsev neeg cov noob, tuaj yeem ua rau muaj zog tiv thaiv kab mob. MOG tau pom tias muaj kev tiv thaiv kab mob hauv nruab nrab ntawm lub paj hlwb, thiab cov ntaub ntawv qhia ua ntej tsis ntev los no qhia tias MOG tau qhia nyob rau hauv ntau yam ntawm neutrophils, uas kuj txhawb kev tiv thaiv kab mob ntawm MOG. Txawm hais tias MOG tsis muaj nyob hauv cov tsiaj tsis pub noj ntawm myelin, nws tuaj yeem piav qhia ntau txoj hauv kev. Ib qho kev piav qhia yog tias MOG tsis ncaj qha ua rau cov txheej txheem myelin, thiab ntau dua, nws tuaj yeem kho myelin thiab lwm cov txheej txheem hauv vivo. Ib feem, xws li kev sib cuag ntawm lub cev tiv thaiv kab mob; Lwm qhov kev piav qhia yog tias MOG yog qhov tshwj xeeb rau kev tiv thaiv kab mob ntawm CNS myelin sheath, tsis zoo li lub paj hlwb peripheral myelin sheath, uas ua rau txoj hauv kev zoo sib xws hauv vivo. Tiv thaiv DNA tshuaj tiv thaiv encoding MOG (MOG) - DNA tuaj yeem tiv thaiv nas nrog kev sim autoimmune encephalomyelitis (EAE experimentalautoimmuneencephalomyelitis), yog los ntawm lub luag haujlwm ntawm kev ua kom tiav C3d. Yog li ntawd, CNS myelin sheath yuav tsum muaj cov khoom ntxiv uas khi Ctq, uas ua rau kom ua kom tiav.

 

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