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  • MOG (35-55) CAS 149635-73-4 ka theko e ngata

Aug. 03, 2023 09:27 Khutlela lethathamong

MOG (35-55) CAS 149635-73-4 ka theko e ngata



MOG (35-55) CAS 149635-73-4 ka theko e ngata

Myelin oligodendrocytes glycoprotein (myelinoligodendrocyteglyco - protheine, MOG) ke tsamaiso ea methapo e bohareng (centralnervoussystem, CNS) myelin outermost content minimal myelin protein composition, Ke subtype ea immunoglobulin IgG1, e laolang ka katleho e tlatselletsang-e itšetlehileng ka lik'hemik'hale tsa cytotoxicity. - e bakoang ke demyelination ea MS. MOG antibody resistance in multiple sclerosis (multiplesclerosis, MS) e phetha karolo ea bohlokoa haholo tšebetsong ea mafu, e bakoang ke MOG test autoimmune encephalomyelitis (experimentalautoimmuneencephalomyelitis, EAE ke mohlala oa liphoofolo o tsebahalang lefatšeng ka bophara oa MS.

Litšobotsi tsa 1. Molek'hule ea ho khomarela OG immunoglobuloin-like region e tšoana le sebaka se tšoanang sa butyrophilin, 'me khoho ea BG antigen e ke ke ea lemoha mosebetsi oa MOG. Sebaka sa libaka tsa MOGs, ho amoheloa ha MOG e le immunoglobulin superfamily, le ponahalo ea Lα / HNK-1 carbohydrate antigen epitopes kaofela li tšehetsa mosebetsi oa MOG e le limolek'hule tsa ho khomarela kapa li-cell receptors. O fumane ho alpha / HNK L - 1 antigen epitope e ile ea khetholloa e le myelin e amanang le glycoprotein (myelin - e amanang le glycoprotein, MAG) le P0, ka bobeli e na le karolo ea ho khomarela ea protheine ea myelin. Haeba MOG e na le ts'ebetso ea ho khomarela, e ka 'na ea kopana le likarolo tse ling tsa tsamaiso ea methapo e bohareng ntle le eona; Ho nahanoa hore haeba MOG e na le karolo e kholo ea ho khomarela lisele, MOG e ka sebetsa e le "khomaretsi" ea sekhomaretsi pakeng tsa likhoele tsa myelin tse haufi 'me tsa etsahala hamorao ts'ebetsong ea myelination. 2. Microtubule stable regulator 8-18C5 antibody e ka baka ho senyeha ha MBP ka sheath ea myelin e hloekisitsoeng. 3. Kenya tshebetsong tlatsana MOG liphatsa tsa lefutso ka sehloohong histocompatibility complex (MHC) majorhistocompatibilitChemicalbookycomplex, sebaka se tšoanang le khoho MHC antigen B - G, sebopeho sa eona se tšoana le malapa a liphatsa tsa lefutso, a ka baka karabelo e matla ea ho itšireletsa mafung. MOG e nahanoa hore e na le ts'ebetso ea 'mele ea ho itšireletsa mafung tsamaisong ea methapo e bohareng,' me litlaleho tsa morao-rao tsa pele li fana ka maikutlo a hore MOG e hlahisoa ka mefuta e mengata ea li-neutrophils, tse tšehetsang ts'ebetso ea 'mele ea ho itšireletsa mafung ea MOG. Le hoja MOG e le sieo mefuteng e sa jeseng ea myelin, e ka hlalosoa ka litsela tse 'maloa. Tlhaloso e 'ngoe ke hore MOG ha e sebetse ka ho toba lits'ebetsong tsa myelin,' me ka nepo, e ka 'na ea kopanya myelin le lits'ebetso tse ling ho vivo. Karolo e le 'ngoe, joalo ka ho kopana pakeng tsa sesole sa' mele; Tlhaloso e 'ngoe ke hore MOG e batla e tobile ts'ebetsong ea 'mele ea ho itšireletsa mafung ea CNS myelin sheath, ho fapana le tsamaiso ea methapo ea methapo ea myelin sheath, e kenyang tsela ea khale ea ho tlatsana ka har'a vivo. Protective DNA vaccine encoding MOG (MOG) - DNA e ka thibela litoeba tse nang le liteko tsa autoimmune encephalomyelitis (EAE experimentalautoimmuneencephalomyelitis), ke ka karolo ea tlatsetso ea ts'ebetsong ea C3d. Ka hona, sheath ea CNS myelin e tlameha ho ba le likarolo tse tlatselletsang tse tlamang Ctq, tse lebisang ho ts'ebetsong ea tlatsetso.

 

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