HUMANIN TRIFLUOROACETATE CAS 330936-69-1    Whatsapp: +86-19031013676

Humanin (HN) yog lub ntuj luv luv mitochondrial polypeptide nrog antiapoptotic thiab neuroprotective teebmeem^[2]. Humanin tiv thaiv hlwb tiv thaiv ntau yam kab mob, suav nrog oxidative kev nyuaj siab thiab cytotoxicity induced los ntawm ntau yam stimuli^[3] nrog kev ua haujlwm dav dav ntawm pancreas, hlwb, testis, thiab lub plawv^[4]. Humanin thiab nws cov analogues tuaj yeem siv los ua cov hom phiaj kho mob zoo tiv thaiv kab mob neuroprotective thiab neurodegenerative.^[1].

Humanin nce cell viability. HN txo qis feem pua ​​​​ntawm cov hlwb hypodiploid KGN nrog rau feem pua ​​​​ntawm apoptotic KGN hlwb. Humanin tuaj yeem suav hais tias yog qhov tseem ceeb ntawm kev muaj sia nyob hauv cov kab mob qog no^[5]. Humanin tuaj yeem koom nrog hauv cov lus teb ntawm HLECs rau oxidative kev nyuaj siab, thiab hais tias HN qhia tau zoo heev nyob rau hauv oxidative kev nyuaj siab. Tsis tas li ntawd, exogenous HN txo intracellular ROS cov ntsiab lus thiab kev puas tsuaj mitochondrial, thiab txhim kho mitochondrial biosynthesis; Txawm li cas los xij, qhov kev tiv thaiv no tau poob rau hauv ib qho endogenous Humanin knockdown cell qauv^[6]. Kev sib cuam tshuam ntawm Humanin thiab nws cov receptors (CNTFR, WSX-1, thiab gp130) tuaj yeem qhib STAT3 kev taw qhia txoj hauv kev los ntawm kev nce hauv STAT3 qhia thiab yog li ua rau nce ntawm beta cell ciaj sia nyob rau hauv lub txiav.^[9].

Humanin kev tswj hwm muaj cov teebmeem neuroprotective hauv vitro hauv tib neeg kab lis kev cai qauv thiab txaus los txhim kho kev paub hauv vivo hauv cov nas muaj hnub nyoog^[8]. Kom nkag siab txog cov teebmeem ntawm Humanin ntawm lub hlwb kev ua haujlwm, Cov nyhuv ntawm S14G-HN ntawm diazepam (DZP)-vim kev nco tsis zoo thiab kev ntxhov siab hauv cov nas uas siv cov khoom paub txog kev sim thiab xoom-maze test. Intraperitoneal txhaj ntawm S14G-HN thim rov qab DZP-vim kev nco tsis txaus, thaum tsis muaj kev hloov pauv tseem ceeb hauv kev coj cwj pwm ntawm kev ntxhov siab. S14G-Humanin tsis muaj kev cuam tshuam rau locomotor kev ua haujlwm hauv ob qho kev sim, qhia tias S14G-HN tsis cuam tshuam rau lub cev ua haujlwm lossis kev txhawb nqa.^[7].

Cov ntaub ntawv:
[1]. Hazafa A, Batool A, et al. Humanin: Ib qho mitochondrial-derived peptide hauv kev kho cov kab mob apoptosis. Lub neej Sci. 2021 Peb 1, 264:118679. doi: 10.1016/j.lfs.2020.118679. Epub 2020 Oct 29. PMID: 33130077.
[2]. Salemi M, Ridolfo F, et, al.Humanin gene qhia hauv fibroblast ntawm Down syndrome cov ntsiab lus. Int J Med Sci. 2020 Lub Ib Hlis 18; 17(3): 320-324. doi: 10.7150/ijms.39145. PIB: 32132866; PIB: PMC7053358.
[3]. Luciano F, Zhai D, et, al.Cytoprotective peptide humanin khi thiab inhibits proapoptotic Bcl-2/Bax tsev neeg protein BimEL. J Biol Chem. 2005 Lub Plaub Hlis 22; 280(16): 15825-35. doi: 10.1074/jbc.M413062200 ib. Epub 2005 Jan 20. PMID: 15661735.
[4]. Paharkova V, Alvarez G, et al. Rat Humanin yog encoded thiab txhais nyob rau hauv mitochondria thiab yog nyob rau hauv lub mitochondrial compartment qhov twg nws tswj ROS ntau lawm. Mol Cell Endocrinol. 2015 Sep 15; 413:96-100. doi: 10.1016/j.mce.2015.06.015. Epub 2015 Jun 23. PMID: 26116236.
[5]. Marvaldi C, Martin D, thiab al. Mitochondrial humanin peptide ua raws li cytoprotective yam hauv granulosa cell ciaj sia. Kev tsim tawm. 2021 Lub Plaub Hlis 20; 161(5): 581-591. doi: 10.1530/REP-20-0197 ib. PIB: 33764899.
[6]. Yang H, Cui Y, et, al.Cytoprotective luag hauj lwm ntawm humanin nyob rau hauv lub lens epithelial cell oxidative stress?induced raug mob. Mol Med Rep. 2020 Aug; 22(2): 1467-1479. doi: 10.3892/mmr.2020.11202. Epub 2020 Jun 2. PMID: 32627019; PIB: PMC7339735.
[7]. Murakami M, Nagahama M, et al. Humanin ameliorates diazepam-induced nco deficit nyob rau hauv nas. Neuropeptides. Peb Hlis 2017; 62:65-70. doi: 10.1016/j.npep.2016.10.008. Epub 2016 Oct 29. PMID: 27814910.
[8]. Yen K, Wan J, et, al.Humanin Tiv thaiv hnub nyoog ntsig txog kev paub txog kev poob qis hauv nas thiab koom nrog kev paub txog hnub nyoog zoo dua hauv tib neeg. Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7. PIB: 30242290; PIB: PMC6154958.
[9] .Charununtakorn ST, Shinlapawittayatorn K, et, al.Potential Roles of Humanin on Apoptosis in the Heart. Cardiovasc Ther. Peb Hlis 2016; 34(2): 107-14. doi: 10.1111/1755-5922.12168 ib. PIB: 26667157.