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ʻO Humanin (HN) kahi polypeptide mitochondrial pōkole kūlohelohe me nā hopena antiapoptotic a me nā neuroprotective.^[2]. Mālama ʻo Humanin i nā cell mai nā maʻi like ʻole, me ke koʻikoʻi oxidative a me ka cytotoxicity i hoʻoulu ʻia e nā ʻano hoʻoulu^[3] me ka hana ākea ākea ma ka pancreas, lolo, testis, a me ka naʻau^[4]. Hiki ke hoʻohana ʻia ʻo Humanin a me kāna mau analogs e like me nā pahuhopu therapeutic maikaʻi e kūʻē i nā maʻi neuroprotective a me neurodegenerative^[1].

Ua hoʻonui ʻo Humanin i ka hiki ke ola. Ua hoʻemi ʻo HN i ka pākēneka o nā pūnaewele KGN hypodiploid a me ka pākēneka o nā pūnaewele KGN apoptotic. Hiki ke noʻonoʻo ʻia ʻo Humanin he mea e ola ai i kēia laina cell tumor^[5]. Hiki i ka Humanin ke komo i ka pane o HLEC i ke koʻikoʻi oxidative, a ua hoʻonui nui ʻia ka ʻōlelo HN ma lalo o nā kūlana koʻikoʻi oxidative. Eia kekahi, hoʻemi ka HN exogenous i ka ʻike intracellular ROS a me ka pōʻino mitochondrial, a hoʻonui i ka biosynthesis mitochondrial; akā naʻe, ua nalowale kēia pale i loko o kahi kumu hoʻohālike hoʻohālike humanin knockdown cell^[6]. Hiki i ka launa pū ʻana o Humanin a me kāna mau mea loaʻa (CNTFR, WSX-1, a me gp130) ke hoʻāla i ke ala hōʻailona STAT3 ma o ka hoʻonui ʻana i ka hōʻike STAT3 a no laila ke alakaʻi i ka piʻi ʻana o ke ola o nā cell beta i ka pancreas.^[9].

Loaʻa i ka hoʻokele Humanin nā hopena neuroprotective in vitro i nā hiʻohiʻona moʻomeheu cell kanaka a lawa ia e hoʻomaikaʻi ai i ka cognition in vivo i nā ʻiole kahiko.^[8]. No ka hoʻomaopopo ʻana i ka hopena o Humanin i ka hana o ka lolo, ʻO ka hopena o S14G-HN ma ka diazepam (DZP) -induced memory impairment a me ka hopohopo i nā ʻiole me ka hoʻohana ʻana i ka hōʻike ʻike mea a me ka hōʻike zero-maze. Intraperitoneal injection of S14G-HN hoʻohuli i ka DZP-induced memory deficit, ʻoiai ʻaʻole i ʻike ʻia kahi loli nui i nā hōʻailona hana o ka hopohopo. S14G- ʻAʻohe hopena o Humanin i ka hana locomotor i kēlā me kēia hoʻokolohua, e hōʻike ana ʻaʻole i pili ka S14G-HN i ka hana kino a i ʻole ka hoʻoikaika kino.^[7].

Kuhikuhi:
[1]. Hazafa A, Batool A, et,al. Humanin: He peptide i loaʻa i ka mitochondrial i ka mālama ʻana i nā maʻi pili apoptosis. Ola Sci. 2021 Ian 1;264:118679. doi: 10.1016/j.lfs.2020.118679. Epub 2020 ʻOkakopa 29. PMID: 33130077.
[2]. Salemi M, Ridolfo F, et, al.Humanin gene expression i ka fibroblast o nā kumuhana Down syndrome. Int J Med Sci. 2020 Ian 18;17(3):320-324. doi: 10.7150/ijms.39145. PMID: 32132866; PMCID: PMC7053358.
[3]. ʻO Luciano F, Zhai D, et, al.Cytoprotective peptide humanin hoʻopaʻa a hoʻopaʻa i ka proapoptotic Bcl-2 / Bax ʻohana protein BimEL. J Biol Chem. 2005 Apr 22;280(16):15825-35. doi: 10.1074/jbc.M413062200. Epub 2005 Jan 20. PMID: 15661735.
[4]. Paharkova V, Alvarez G, a me al. Hoʻopili ʻia ʻo Rat Humanin a unuhi ʻia i ka mitochondria a ua hoʻonohonoho ʻia i ka ʻāpana mitochondrial kahi e hoʻoponopono ai i ka hana ROS. Mol Cell Endocrinol. 2015 Sep 15;413:96-100. doi: 10.1016/j.mce.2015.06.015. Epupa 2015 Iune 23. PMID: 26116236.
[5]. Marvaldi C, Martin D, a me al. Hana ʻo Mitochondrial humanin peptide ma ke ʻano he cytoprotective factor i ke ola cell granulosa. Hana hou. 2021 Apr 20;161(5):581-591. doi: 10.1530/REP-20-0197. PMID: 33764899.
[6]. ʻO Yang H, Cui Y, a me, al.Cytoprotective kuleana o ke kanaka i ka lens epithelial cell oxidative stress?induced injury. Mol Med Rep. 2020 Aug;22(2):1467-1479. doi: 10.3892/mmr.2020.11202. Epupa 2020 Iune 2. PMID: 32627019; PMCID: PMC7339735.
[7]. Murakami M, Nagahama M, et,al. Hoʻomaikaʻi ʻo Humanin i ka deficit hoʻomanaʻo ʻana i ka diazepam i nā ʻiole. Nā neuropeptides. 2017 Apr;62:65-70. doi: 10.1016/j.npep.2016.10.008. Epupa 2016 ʻOkakopa 29. PMID: 27814910.
[8]. ʻO Yen K, Wan J, et, al. Kāohi ʻo Humanin i ka emi ʻana o ka cognitive e pili ana i nā makahiki i nā ʻiole a pili pū me ka hoʻomaikaʻi ʻana i ka makahiki cognitive i loko o ke kanaka. Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7. PMID: 30242290; PMCID: PMC6154958.
[9] .Charununtakorn ST, Shinlapawittayatorn K, et, al. Nā Hana Pono o Humanin ma Apoptosis i loko o ka Puʻuwai. Cardiovasc Ther. 2016 Apr;34(2):107-14. doi: 10.1111/1755-5922.12168. PMID: 26667157.