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Jul. 12, 2023 09:51 Laghachi na ndepụta

HUMANIN TRIFLUOROACETATE cas 330936-69-1 WHATSAPP:+86-19031013676



HUMANIN TRIFLUOROACETATE cas 330936-69-1    WHATSAPP:+86-19031013676

Humanin (HN) bụ polypeptide mitochondrial dị mkpụmkpụ nke nwere mmetụta antiapoptotic na neuroprotective.[2]. Humanin na-echebe mkpụrụ ndụ megide ọrịa dị iche iche, gụnyere nrụgide oxidative na cytotoxicity nke ihe mkpali dị iche iche kpatara.[3] na-arụ ọrụ dị iche iche na pancreas, ụbụrụ, testis, na obi[4]. Enwere ike iji Humanin na analogs ya dị ka ezigbo ebumnuche ọgwụgwọ megide ọrịa neuroprotective na neurodegenerative.[1].

Humanin mụbara ikike cell. HN belatara pasentị nke mkpụrụ ndụ hypodiploid KGN yana pasent nke mkpụrụ ndụ KGN apoptotic. Enwere ike were Humanin dị ka ihe na-enyere aka ịlanarị n'ahịrị cell tumor a[5]. Humanin nwere ike itinye aka na nzaghachi nke HLEC na nrụgide oxidative, na okwu HN ahụ kwadoro nke ọma n'okpuru ọnọdụ nrụgide oxidative. Ọzọkwa, exogenous HN belatara intracellular ROS ọdịnaya na mitochondrial mmebi, na kwalite mitochondrial biosynthesis; Otú ọ dị, nchebe a tụfuru n'ụdị sel mmadụ knockdown endogenous[6]. Mmekọrịta nke Humanin na ndị na-anabata ya (CNTFR, WSX-1, na gp130) nwere ike mee ka ụzọ mgbaàmà STAT3 rụọ ọrụ site na mmụba nke okwu STAT3 ma mee ka mmụba nke beta cell dị ndụ na pancreas.[9].

Nlekọta Humanin nwere mmetụta neuroprotective na vitro na ụdị omenala sel mmadụ ma zuru oke iji melite cognition na vivo na ụmụ oke agadi.[8]. Iji ghọta mmetụta nke Humanin na ọrụ ụbụrụ, Mmetụta nke S14G-HN na diazepam (DZP) na-akpata nsogbu nchekwa na nchekasị na ụmụ oke na-eji ule njirimara ihe na ule efu efu. Ngwunye intraperitoneal nke S14G-HN weghaara ụkọ nchekwa nchekwa nke DZP, ebe ọ dịghị mgbanwe dị ịrịba ama na akara omume nke nchegbu. S14G- Humanin enweghị mmetụta na ọrụ locomotor na ule ọ bụla, na-egosi na S14G-HN emetụtaghị ọrụ anụ ahụ ma ọ bụ mkpali.[7].

Ntụaka:
[1]. Hazafa A, Batool A, et, al. Humanin: peptide sitere na mitochondrial na ọgwụgwọ ọrịa ndị metụtara apoptosis. Ndụ Sci. 2021 Jenụwarị 1;264:118679 . doi: 10.1016/j.lfs.2020.118679. Epub 2020 Ọkt 29. PMID: 33130077.
[2]. Salemi M, Ridolfo F, et, al.Humanin gene okwu na fibroblast nke Down syndrome isiokwu. Int J Med Sci. 2020 Jenụwarị 18; 17 (3): 320-324 . doi: 10.7150/ijms.39145. PMID: 32132866; PMCID: PMC7053358.
[3]. Luciano F, Zhai D, et, al.Cytoprotective peptide humanin na-ejikọta ma gbochie proapoptotic Bcl-2/Bax protein ezinụlọ BimEL. J Biol Chem. 2005 Eprel 22;280 (16): 15825-35 . doi: 10.1074/jbc.M413062200. Epub 2005 Jan 20. PMID: 15661735.
[4]. Paharkova V, Alvarez G, et, al. Oke Humanin ka etinyere ma tụgharịa ya na mitochondria ma debe ya na ngalaba mitochondrial ebe ọ na-ahazi mmepụta ROS. Endocrinol cell mol. 2015 Septemba 15; 413: 96-100 . doi: 10.1016/j.mce.2015.06.015. Epub 2015 Jun 23. PMID: 26116236.
[5]. Marvaldi C, Martin D, et, al. Mitochondrial humanin peptide na-arụ ọrụ dị ka ihe na-akpata cytoprotective na ndụ granulosa cell. Mmeputakwa. 2021 Eprel 20; 161 (5): 581-591 . doi: 10.1530/REP-20-0197. PMID: 33764899.
[6]. Yang H, Cui Y, et, al.Cytoprotective ọrụ nke humanin na oghere epithelial cell oxidative stress?kpatara mmerụ. Mol Med Rep. 2020 Ọgọst; 22 (2): 1467-1479. doi: 10.3892/mmr.2020.11202. Epub 2020 Jun 2. PMID: 32627019; PMCID: PMC7339735.
[7]. Murakami M, Nagahama M, et, al. Humanin na-emezi mperi ebe nchekwa diazepam kpatara na ụmụ oke. Neuropeptides. 2017 Eprel; 62: 65-70 . doi: 10.1016/j.npep.2016.10.008. Epub 2016 Ọkt 29. PMID: 27814910.
[8]. Yen K, Wan J, et, al.Humanin na-egbochi mbelata ọgụgụ isi nke afọ na ụmụ oke ma na-ejikọta ya na ọganihu ọgụgụ isi n'ime mmadụ. Sci Rep. 2018 Sep 21; 8 (1): 14212 . doi: 10.1038/s41598-018-32616-7. PMID: 30242290; PMCID: PMC6154958.
[9] .Charununtakorn ST, Shinlapawittayatorn K, et, al. Ọrụ nwere ike ime nke Humanin na Apoptosis na Obi. Cardiovasc Ther. 2016 Eprel; 34 (2): 107-14 . doi: 10.1111/1755-5922.12168. PMID: 26667157.

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