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Humanin (HN) gajeriyar mitochondrial polypeptide ce ta halitta tare da tasirin antiapoptotic da neuroprotective.^[2]. Humanin yana kare kwayoyin halitta daga cututtuka daban-daban, ciki har da damuwa na oxidative da cytotoxicity da aka jawo ta hanyoyi daban-daban.^[3] tare da faffadan ayyuka akan pancreas, kwakwalwa, testis, da zuciya^[4]. Humanin da analogs za a iya amfani da su azaman kyakkyawar maƙasudin warkewa daga cututtukan neuroprotective da neurodegenerative.^[1].

Humanin ya karu da iyawar tantanin halitta. HN ya rage yawan adadin ƙwayoyin hypodiploid KGN da kuma adadin ƙwayoyin KGN apoptotic. Ana iya la'akari da Humanin a matsayin abin da zai iya tsira a cikin wannan layin tantanin halitta^[5]. Humanin na iya shiga cikin amsawar HLECs zuwa damuwa na oxidative, kuma wannan magana ta HN ta kasance mai mahimmanci a ƙarƙashin yanayin damuwa. Bugu da ƙari kuma, exogenous HN ya rage abun ciki na ROS na ciki da kuma lalacewar mitochondrial, da kuma inganta mitochondrial biosynthesis; duk da haka, an rasa wannan kariyar a cikin ƙirar ƙwanƙwasa ta Humanin endogenous^[6]. Harkokin hulɗar Humanin da masu karɓa (CNTFR, WSX-1, da gp130) na iya kunna hanyar siginar STAT3 ta hanyar karuwa a cikin maganganun STAT3 kuma saboda haka ya haifar da karuwar beta cell rayuwa a cikin pancreas.^[9].

Gudanar da Humanin yana da tasirin neuroprotective a cikin vitro a cikin samfuran al'adun sel na ɗan adam kuma ya isa ya inganta fahimta a cikin vivo a cikin tsofaffin beraye.^[8]. Don fahimtar tasirin Humanin akan aikin kwakwalwa, Sakamakon S14G-HN akan diazepam (DZP) -induced ƙwaƙwalwar ƙwaƙwalwa da damuwa a cikin mice ta amfani da gwajin gano abu da gwajin sifili. Allurar intraperitoneal na S14G-HN ta sake juyar da ƙarancin ƙwaƙwalwar ajiya na DZP, yayin da ba a sami babban canji a cikin alamun halayen damuwa ba. S14G- Humanin ba shi da wani tasiri a kan ayyukan locomotor a kowane gwaji, yana nuna cewa S14G-HN bai shafi aikin jiki ko motsa jiki ba.^[7].

Magana:
[1]. Hazafa A, Batool A, et, al. Humanin: peptide wanda aka samu mitochondrial a cikin maganin cututtukan da ke da alaƙa da apoptosis. Rayuwa Sci. 2021 Jan 1;264:118679. doi: 10.1016/j.lfs.2020.118679. Epub 2020 Oct 29. PMID: 33130077.
[2]. Salemi M, Ridolfo F. Int J Med Sci. 2020 Janairu 18; 17 (3): 320-324. doi: 10.7150/ijms.39145. PMID: 32132866; Saukewa: PMC7053358.
[3]. Luciano F, Zhai D, et, al.Cytoprotective peptide humanin yana ɗaure kuma yana hana proapoptotic Bcl-2/Bax furotin iyali BimEL. J Biol Chem. 2005 Afrilu 22;280 (16): 15825-35. doi: 10.1074/jbc.M413062200. Epub 2005 Jan 20. PMID: 15661735.
[4]. Paharkova V, Alvarez G, et, al. Rat Humanin an ɓoye shi kuma an fassara shi a cikin mitochondria kuma an keɓe shi zuwa sashin mitochondrial inda yake sarrafa samar da ROS. Mol Cell Endocrinol. 2015 Satumba 15; 413: 96-100. doi: 10.1016/j.mce.2015.06.015. Epub 2015 Juni 23. PMID: 26116236.
[5]. Marvaldi C, Martin D, et, al. Mitochondrial humanin peptide yana aiki azaman cytoprotective factor a cikin rayuwar granulosa cell. Haihuwa. 2021 Afrilu 20; 161 (5): 581-591. doi: 10.1530/REP-20-0197. Saukewa: 33764899.
[6]. Yang H, Cui Y, et, al.Cytoprotective Matsayin humanin a cikin ruwan tabarau epithelial cell oxidative danniya?jawo rauni. Mol Med Wakili 2020 Agusta; 22 (2): 1467-1479. doi: 10.3892/mmr.2020.11202. Epub 2020 Jun 2. PMID: 32627019; Saukewa: PMC7339735.
[7]. Murakami M, Nagahama M, et, al. Humanin yana inganta ƙarancin ƙwaƙwalwar ajiya na diazepam a cikin beraye. Neuropeptides. 2017 Afrilu; 62: 65-70. doi: 10.1016/j.npep.2016.10.008. Epub 2016 Oct 29. PMID: 27814910.
[8]. Yen K, Wan J, et, al.Humanin Yana Hana Rashin Fahimtar Shekaru Masu Alaƙa a cikin Mice kuma yana Haɗe da Ingantaccen Shekarun Fahimi a cikin ɗan adam. Sci Rep. 2018 Satumba 21; 8 (1): 14212. doi: 10.1038/s41598-018-32616-7. PMID: 30242290; Saukewa: PMC6154958.
[9] .Charununtakorn ST, Shinlapawittayatorn K, et, al.Iwusuwar Matsayin Humanin akan Apoptosis a cikin Zuciya. Cardiovasc Ther. 2016 Afrilu; 34 (2): 107-14. doi: 10.1111/1755-5922.12168. Saukewa: 26667157.