I-HUMANIN TRIFLUOROACETATE cas 330936-69-1    WHATSAPP:+86-19031013676

I-Humanin (HN) yipolypeptide emfutshane ye-mitochondrial yendalo ene-antiapoptotic kunye ne-neuroprotective effects.^[2]. I-Humanin ikhusela iiseli kwizifo ezahlukeneyo, kubandakanywa uxinzelelo lwe-oxidative kunye ne-cytotoxicity ebangelwa zizenzo ezahlukeneyo.^[3] kunye nomsebenzi obanzi kwi-pancreas, ingqondo, amatyhalarha kunye nentliziyo^[4]. I-Humanin kunye ne-analogs yayo inokusetyenziswa njengeethagethi ezilungileyo zonyango ngokuchasene nezifo ze-neuroprotective kunye ne-neurodeergenerative.^[1].

Humanin yandise ukusebenza kweeseli. I-HN yehla ipesenti yeeseli ze-hypodiploid KGN kunye nepesenti yeeseli ze-aptotic KGN. I-Humanin inokuthathwa njengento yokusinda kulo mgca weseli yethumba^[5]. I-Humanin inokubandakanyeka ekuphenduleni kwe-HLECs kuxinzelelo lwe-oxidative, kwaye inkcazo ye-HN yayilawulwa kakhulu phantsi kweemeko zoxinzelelo lwe-oxidative. Ngaphezu koko, i-HN yangaphandle yanciphisa umxholo we-ROS we-intracellular kunye nomonakalo we-mitochondrial, kunye ne-biosynthesis ye-mitochondrial ephuculweyo; nangona kunjalo, olu khuseleko lwalahleka kwimodeli yeseli ye-Hunin engapheliyo^[6]. Ukusebenzisana kwe-Humanin kunye ne-receptors yayo (i-CNTFR, i-WSX-1, kunye ne-gp130) inokusebenzisa indlela yokubonisa i-STAT3 ngokunyuka kwenkcazo ye-STAT3 kwaye ngenxa yoko ikhokelela ekwandeni kokusinda kweeseli ze-beta kwi-pancreas.^[9].

Ulawulo lwe-Humanin luneziphumo ze-neuroprotective kwi-vitro kwiimodeli zenkcubeko yeeseli zabantu kwaye zanele ukuphucula ukuqonda kwi-vivo kwiimpuku ezikhulileyo.^[8]. Ukuqonda imiphumo ye-Humanin ekusebenzeni kwengqondo, Umphumo we-S14G-HN kwi-diazepam (DZP) -ukwenza ukukhubazeka kwememori kunye nokuxhalaba kwiigundane usebenzisa uvavanyo lokuqaphela into kunye novavanyo lwe-zero-maze. Inaliti ye-Intraperitoneal ye-S14G-HN iguqule i-DZP-induced memory deficit, kanti akukho tshintsho lubalulekileyo luye lwabonwa kwiimpawu zokuziphatha zokukhathazeka. I-S14G- I-Humanin yayingenayo impembelelo kumsebenzi we-locomotor kulo naluphi na uvavanyo, ebonisa ukuba i-S14G-HN ayizange ichaphazele ukusebenza komzimba okanye ukukhuthaza.^[7].

IiReferensi:
[1]. Hazafa A, Batool A, et,al. I-Humanin: I-peptide evela kwi-mitochondrial kunyango lwezifo ezinxulumene ne-apoptosis. Ubomi beSayensi. 2021 Jan 1;264:118679. doi: 10.1016/j.lfs.2020.118679. Epub 2020 Oct 29. PMID: 33130077.
[2]. Salemi M, Ridolfo F, et, al.Humanin gene expression in fibroblast of Down syndrome subjects. Int J Med Sci. 2020 Jan 18;17(3):320-324. doi: 10.7150/ijms.39145. PMID: 32132866; I-PMCID: PMC7053358.
[3]. ULuciano F, uZhai D, et, al.Cytoprotective peptide humanin ibopha kwaye inqanda iproapoptotic Bcl-2 / Bax yeprotheni yentsapho ye-BimEL. J Biol Chem. 2005 Apr 22; 280 (16): 15825-35. doi: 10.1074/jbc.M413062200. Epub 2005 Jan 20. PMID: 15661735.
[4]. Paharkova V, Alvarez G, et,al. I-Rat Humanin ifakwe kwikhowudi kwaye iguqulelwe kwi-mitochondria kwaye ifakwe kwi-mitochondrial compartment apho ilawula ukuveliswa kwe-ROS. I-Mol Cell Endocrinol. 2015 Sep 15;413:96-100. doi: 10.1016/j.mce.2015.06.015. Epub 2015 Jun 23. PMID: 26116236.
[5]. UMarvaldi C, uMartin D, et, al. I-Mitochondrial humanin peptide isebenza njenge-cytoprotective factor kwi-granulosa cell survival. Ukuveliswa kwakhona. 2021 Epreli 20; 161 (5): 581-591. doi: 10.1530/REP-20-0197. PMID: 33764899.
[6]. Yang H, Cui Y, et, al.Cytoprotective indima ye-human kwi-lens epithelial cell oxidative stress?induced injury. UMol Med Rep. 2020 Aug;22(2):1467-1479. doi: 10.3892/mmr.2020.11202. Epub 2020 Jun 2. PMID: 32627019; I-PMCID: PMC7339735.
[7]. Murakami M, Nagahama M, et,al. I-Humanin yenza intsilelo yenkumbulo eyenziwe yi-diazepam kwiimpuku. IiNeuropeptides. 2017 Epreli; 62:65-70. doi: 10.1016/j.npep.2016.10.008. Epub 2016 Oct 29. PMID: 27814910.
[8]. U-Yen K, u-Wan J, et, al.U-Humanin unqanda ukuhla kweNgcaciso eNxulumene nobudala kwiiMice kwaye inxulunyaniswa nokuPhuculwa kweNgcaciso yeminyaka kuBantu. Sci Rep. 2018 Sep 21; 8 (1): 14212. doi: 10.1038/s41598-018-32616-7. PMID: 30242290; I-PMCID: PMC6154958.
[9] .Charununtakorn ST, Shinlapawittayatorn K, et, al.Iindima ezinokwenzeka zeHumanin kwi-Apoptosis kwiNtliziyo. ICardiovasc Ther. 2016 Epreli;34(2):107-14. doi: 10.1111/1755-5922.12168. PMID: 26667157.