I-HUMANIN TRIFLUOROACETATE cas 330936-69-1    WHATSAPP:+86-19031013676

I-Humanin (HN) iyi-polypeptide emfushane yemvelo ye-mitochondrial enemiphumela ye-antiapoptotic kanye neuroprotective.^[2]. I-Humanin ivikela amangqamuzana ezifweni ezahlukahlukene, kufaka phakathi ukucindezeleka kwe-oxidative kanye ne-cytotoxicity ebangelwa izisusa ezihlukahlukene.^[3] ngomsebenzi we-spectrum ebanzi kumanyikwe, ubuchopho, amasende, nenhliziyo^[4]. I-Humanin nama-analogs ayo ingasetshenziswa njengezinhloso ezinhle zokwelapha ngokumelene nezifo ze-neuroprotective kanye ne-neurodeergenerative.^[1].

I-Humanin ikhulise ukusebenza kwamaseli. I-HN yehlise iphesenti lamaseli e-hypodiploid KGN kanye nephesenti lamaseli e-apoptotic KGN. I-Humanin ingathathwa njengento ekhuthaza ukusinda kulo mugqa weseli yesimila^[5]. I-Humanin ingase ihileleke ekuphenduleni kwe-HLECs ekucindezelekeni kwe-oxidative, nokuthi inkulumo ye-HN yayilawulwa kakhulu ngaphansi kwezimo zokucindezeleka okwenziwe nge-oxidative. Ngaphezu kwalokho, i-HN yangaphandle yehlise okuqukethwe kwe-ROS ye-intracellular kanye nokulimala kwe-mitochondrial, kanye ne-mitochondrial biosynthesis ethuthukisiwe; kodwa-ke, lesi sivikelo silahlekile kumodeli yeseli ye-Humanin knockdown cell^[6]. Ukusebenzisana kwe-Humanin nama-receptors ayo (i-CNTFR, i-WSX-1, ne-gp130) ingenza kusebenze indlela yokusayina ye-STAT3 ngokukhuphuka kwenkulumo ye-STAT3 futhi ngenxa yalokho kuholele ekwandeni kokusinda kwamaseli e-beta kumanyikwe.^[9].

Ukuphathwa kwe-Humanin kunemiphumela ye-neuroprotective in vitro kumamodeli wesiko lamaseli omuntu futhi kwanele ukuthuthukisa ukuqonda ku-vivo kumagundane asebekhulile.^[8]. Ukuze uqonde imiphumela ye-Humanin ekusebenzeni kobuchopho, Umphumela we-S14G-HN ku-diazepam (DZP) -ukwenza ukukhubazeka kwenkumbulo nokukhathazeka kumagundane esebenzisa ukuhlolwa kokuqashelwa kwento kanye nokuhlolwa kwe-zero-maze. Umjovo we-Intraperitoneal we-S14G-HN ubuyisele emuva ukushoda kwenkumbulo okubangelwa i-DZP, kanti alukho ushintsho olubalulekile olubonwe kumaka wokuziphatha wokukhathazeka. I-S14G- I-Humanin ayizange ibe nomthelela emsebenzini we-locomotor kunoma yikuphi ukuhlolwa, okubonisa ukuthi i-S14G-HN ayizange ithinte ukusebenza komzimba noma ugqozi.^[7].

Izithenjwa:
[1]. Hazafa A, Batool A, et,al. I-Humanin: I-peptide etholakala ku-mitochondrial ekwelapheni izifo ezihlobene ne-apoptosis. Impilo Sci. 2021 Jan 1;264:118679. doi: 10.1016/j.lfs.2020.118679. Epub 2020 Oct 29. PMID: 33130077.
[2]. Salemi M, Ridolfo F, et,al.Humanin gene expression in fibroblast of Down syndrome subjects. I-J Med Sci. 2020 Jan 18;17(3):320-324. doi: 10.7150/ijms.39145. I-PMID: 32132866; I-PMCID: PMC7053358.
[3]. U-Luciano F, u-Zhai D, et, al.Cytoprotective peptide humanin ibopha futhi ivimbele iphrotheni yomndeni we-proapoptotic Bcl-2/Bax BimEL. J Biol Chem. 2005 Apr 22;280(16):15825-35. doi: 10.1074/jbc.M413062200. Epub 2005 Jan 20. PMID: 15661735.
[4]. U-Paharkova V, u-Alvarez G, et, al. I-Rat Humanin ibhalwe ngekhodi futhi yahunyushwa nge-mitochondria futhi yenziwa yasendaweni endaweni ye-mitochondrial lapho ilawula ukukhiqizwa kwe-ROS. I-Mol Cell Endocrinol. 2015 Sep 15;413:96-100. doi: 10.1016/j.mce.2015.06.015. Epub 2015 Jun 23. PMID: 26116236.
[5]. Marvaldi C, Martin D, et,al. I-Mitochondrial humanin peptide isebenza njengesici se-cytoprotective ekusindeni kweseli ye-granulosa. Ukukhiqiza kabusha. 2021 Apr 20;161(5):581-591. doi: 10.1530/REP-20-0197. PMID: 33764899.
[6]. U-Yang H, u-Cui Y, et, al.Indima ye-Cytoprotective ye-humanin ku-lens epithelial cell oxidative stress?induced injury. UMol Med Rep. 2020 Aug;22(2):1467-1479. doi: 10.3892/mmr.2020.11202. I-Epub 2020 Jun 2. PMID: 32627019; I-PMCID: PMC7339735.
[7]. Murakami M, Nagahama M, et,al. I-Humanin ithuthukisa ukushoda kwenkumbulo eyenziwe yi-diazepam kumagundane. Ama-Neuropeptides. 2017 Apr; 62:65-70. doi: 10.1016/j.npep.2016.10.008. I-Epub 2016 Oct 29. PMID: 27814910.
[8]. U-Yen K, u-Wan J, et, al.I-Humanin Ivimbela Ukwehla Kwengqondo Okuhlobene Neminyaka Kumagundane futhi Ihlotshaniswa Neminyaka Ethuthukisiwe Yokuqonda Kubantu. I-Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7. PMID: 30242290; I-PMCID: PMC6154958.
[9] .Charununtakorn ST, Shinlapawittayatorn K, et,al.Izindima Ezingaba khona ze-Humanin ku-Apoptosis Enhliziyweni. I-Cardiovasc Ther. 2016 Apr;34(2):107-14. doi: 10.1111/1755-5922.12168. PMID: 26667157.