HUMANIN TRIFLUOROACETATE cas 330936-69-1    WHATSAPP:+86-19031013676

Humanin (HN) ke polypeptide e khuts'oane ea tlhaho ea mitochondrial e nang le litlamorao tsa antiapoptotic le neuroprotective.^[2]. Humanin e sireletsa lisele khahlanong le mafu a fapaneng, ho kenyelletsa khatello ea oxidative le cytotoxicity e bakoang ke lintho tse fapaneng tse susumetsang.^[3] ka ts'ebetso e pharalletseng ho manyeme, boko, testis, le pelo^[4]. Humanin le li-analogue tsa eona li ka sebelisoa e le lipheo tse ntle tsa kalafo khahlano le mafu a amanang le neuroprotective le neurodegenerative.^[1].

Humanin e ile ea eketsa tšebetso ea lisele. HN e fokolitse peresente ea lisele tsa hypodiploid KGN hammoho le liperesente tsa lisele tsa apoptotic KGN. Humanin e ka nkuoa e le ntho ea ho pholoha moleng ona oa lisele tsa tumor^[5]. Humanin e ka 'na ea ameha karabelong ea HLECs ho khatello ea oxidative, le hore polelo ea HN e ne e laoloa haholo tlas'a maemo a khatello ea mali. Ho feta moo, HN ea ka ntle e ile ea fokotsa litaba tsa ROS tse ka hare ho lisele le tšenyo ea mitochondrial, le ho ntlafatsa biosynthesis ea mitochondrial; leha ho le joalo, ts'ireletso ena e ile ea lahleha ka mokhoa o sa feleng oa Humanin knockdown cell^[6]. Tšebelisano ea Humanin le li-receptors tsa eona (CNTFR, WSX-1, le gp130) e ka kenya tšebetsong tsela ea matšoao ea STAT3 ka keketseho ea polelo ea STAT3 mme ka lebaka leo e lebisa keketsehong ea bophelo ba lisele tsa beta manyeme.^[9].

Tsamaiso ea Humanin e na le litlamorao tsa neuroprotective in vitro mefuteng ea setso sa lisele tsa motho 'me e lekane ho ntlafatsa kutloisiso ea litoeba tse tsofetseng.^[8]. Ho utloisisa liphello tsa Humanin mosebetsing oa boko, Phello ea S14G-HN ho diazepam (DZP) -e baka ho senyeha ha mohopolo le ho tšoenyeha ho litoeba ho sebelisa teko ea ho lemoha ntho le teko ea zero-maze. Ente ea Intraperitoneal ea S14G-HN e ile ea fetola khaello ea memori e susumelitsoeng ke DZP, athe ha ho phetoho e kholo e ileng ea bonoa ho matšoao a boitšoaro ba matšoenyeho. S14G- Humanin e ne e se na phello mosebetsing oa locomotor tekong efe kapa efe, e bontšang hore S14G-HN ha e ame ts'ebetso ea 'mele kapa tšusumetso.^[7].

Litšupiso:
[1]. Hazafa A, Batool A, et,al. Humanin: Peptide e nkiloeng ke mitochondrial kalafong ea mafu a amanang le apoptosis. Life Sci. 2021 Jan 1;264:118679. doi: 10.1016/j.lfs.2020.118679. Epub 2020 Oct 29. PMID: 33130077.
[2]. Salemi M, Ridolfo F, et, al.Humanin gene expression in fibroblast of Down syndrome subjects. Ke J Med Sci. 2020 Jan 18;17(3):320-324. doi: 10.7150/ijms.39145. PMID: 32132866; PMCID: PMC7053358.
[3]. Luciano F, Zhai D, et, al.Cytoprotective peptide humanin e tlama le ho thibela proapoptotic Bcl-2 / Bax protheine ea lelapa BimEL. J Biol Chem. 2005 Apr 22;280(16):15825-35. doi: 10.1074/jbc.M413062200. Epub 2005 Jan 20. PMID: 15661735.
[4]. Paharkova V, Alvarez G, et,al. Rat Humanin e kentsoe le ho fetoleloa ka mitochondria 'me e behiloe sebakeng sa mitochondrial moo e laolang tlhahiso ea ROS. Mol Cell Endocrinol. 2015 Sep 15;413:96-100. doi: 10.1016/j.mce.2015.06.015. Epub 2015 Jun 23. PMID: 26116236.
[5]. Marvaldi C, Martin D, et, al. Mitochondrial humanin peptide e sebetsa e le ntho ea cytoprotective ho pholoheng ha lisele tsa granulosa. Ho ikatisa. 2021 Apr 20;161(5):581-591. doi: 10.1530/REP-20-0197. PMID: 33764899.
[6]. Yang H, Cui Y, et, al.Cytoprotective role of humanin in lens epithelial cell oxidative stress?induced injury. Mol Med Rep. 2020 Aug;22(2):1467-1479. doi: 10.3892/mmr.2020.11202. Epub 2020 Jun 2. PMID: 32627019; PMCID: PMC7339735.
[7]. Murakami M, Nagahama M, et,al. Humanin e matlafatsa khaello ea memori e bakoang ke diazepam ho litoeba. Li-neuropeptides. 2017 Apr; 62:65-70. doi: 10.1016/j.npep.2016.10.008. Epub 2016 Oct 29. PMID: 27814910.
[8]. Yen K, Wan J, et,al.Humanin E Thibela Ho Fokotsa Kelello e Amanang le Lilemo ho Litoeba 'me e Amahanngoa le Lilemo tse Ntlafetseng tsa Kelello Bathong. Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7. PMID: 30242290; PMCID: PMC6154958.
[9] .Charununtakorn ST, Shinlapawittayatorn K, et, al.Mehato e ka khonehang ea Humanin ho Apoptosis ka Pelong. Cardiovasc Ther. 2016 Apr;34(2):107-14. doi: 10.1111/1755-5922.12168. PMID: 26667157.