HUMANIN TRIFLUOROACETATE ca 330936-69-1    WHATSAPP:+86-19031013676

Humanin (HN) ndi polypeptide yayifupi ya mitochondrial yokhala ndi antiapoptotic ndi neuroprotective zotsatira.^[2]. Humanin amateteza maselo ku matenda osiyanasiyana, kuphatikiza kupsinjika kwa okosijeni ndi cytotoxicity yoyambitsidwa ndi zokopa zosiyanasiyana.^[3] ndi ntchito yochuluka pa kapamba, ubongo, testis, ndi mtima^[4]. Humanin ndi ma analogi ake atha kugwiritsidwa ntchito ngati njira zabwino zochizira matenda a neuroprotective ndi neurodegenerative.^[1].

Humanin amawonjezera mphamvu ya ma cell. HN inachepetsa kuchuluka kwa maselo a hypodiploid KGN komanso kuchuluka kwa maselo a apoptotic KGN. Humanin atha kuwonedwa ngati chinthu chothandizira kupulumuka pamzere wama cell chotupa ichi^[5]. Humanin atha kukhudzidwa ndi kuyankha kwa HLECs kupsinjika kwa okosijeni, komanso kuti mawu a HN adasinthidwa kwambiri pansi pa zovuta za okosijeni. Kuphatikiza apo, HN yakunja idachepetsa zomwe zili mu ROS komanso kuwonongeka kwa mitochondrial, ndikuwonjezera kuphatikizika kwa mitochondrial; komabe, chitetezo ichi chinatayika mumtundu wamtundu wa Humanin knockdown cell^[6]. Kuyanjana kwa Humanin ndi zolandilira zake (CNTFR, WSX-1, ndi gp130) zitha kuyambitsa njira yolozera ya STAT3 kudzera pakuwonjezeka kwa mawu a STAT3 ndipo chifukwa chake kumabweretsa kuwonjezeka kwa moyo wa maselo a beta mu kapamba.^[9].

Ulamuliro wa Humanin uli ndi zotsatira za neuroprotective mu vitro mumitundu yama cell amunthu ndipo ndikwanira kupititsa patsogolo kuzindikira mu vivo mu mbewa zakale.^[8]. Kuti mumvetse zotsatira za Humanin pa ntchito ya ubongo, Zotsatira za S14G-HN pa diazepam (DZP) -kuchititsa kuwonongeka kwa kukumbukira ndi nkhawa mu mbewa pogwiritsa ntchito kuyesa kuzindikira kwa chinthu ndi kuyesa kwa zero-maze. Jekeseni wa intraperitoneal wa S14G-HN unasintha kuperewera kwa kukumbukira kwa DZP, pomwe palibe kusintha kwakukulu komwe kunawonedwa pamakhalidwe a nkhawa. S14G- Humanin inalibe mphamvu pazochitika za locomotor mu mayesero aliwonse, kusonyeza kuti S14G-HN sinakhudze kugwira ntchito kwa thupi kapena kulimbikitsana.^[7].

Zolozera:
[1]. Hazafa A, Batool A, et, al. Humanin: Peptide yochokera ku mitochondrial pochiza matenda okhudzana ndi apoptosis. Moyo Sci. 2021 Jan 1; 264:118679. doi: 10.1016/j.lfs.2020.118679. Epub 2020 Oct 29. PMID: 33130077.
[2]. Salemi M, Ridolfo F, et, al.Humanin gene expression in fibroblast of Down syndrome subjects. Ndi J Med Sci. 2020 Jan 18; 17 (3): 320-324. doi: 10.7150/ijms.39145. PMID: 32132866; PMCID: PMC7053358.
[3]. Luciano F, Zhai D, et, al.Cytoprotective peptide humanin imamanga ndikuletsa proapoptotic Bcl-2/Bax protein ya banja BimEL. J Biol Chem. 2005 Apr 22;280(16):15825-35. doi: 10.1074/jbc.M413062200. Epub 2005 Jan 20. PMID: 15661735.
[4]. Paharkova V, Alvarez G, et, al. Rat Humanin imasungidwa ndi kumasuliridwa mu mitochondria ndipo imayikidwa kumalo a mitochondrial komwe imayang'anira kupanga ROS. Mol Cell Endocrinol. 2015 Sep 15; 413:96-100. doi: 10.1016/j.mce.2015.06.015. Epub 2015 Jun 23. PMID: 26116236.
[5]. Marvaldi C, Martin D, et, al. Mitochondrial humanin peptide imagwira ntchito ngati cytoprotective factor pakupulumuka kwa ma cell a granulosa. Kubala. 2021 Apr 20; 161(5): 581-591. doi: 10.1530/REP-20-0197. PMID: 33764899.
[6]. Yang H, Cui Y, et, al. Cytoprotective gawo la humanin mu lens epithelial cell oxidative stress? Mol Med Rep. 2020 Oga; 22 (2): 1467-1479. doi: 10.3892/mmr.2020.11202. Epub 2020 Jun 2. PMID: 32627019; PMCID: PMC7339735.
[7]. Murakami M, Nagahama M, et, al. Humanin imathandizira kuchepa kwa kukumbukira kwa diazepam mu mbewa. Neuropeptides. 2017 Apr; 62:65-70. doi: 10.1016/j.npep.2016.10.008. Epub 2016 Oct 29. PMID: 27814910.
[8]. Yen K, Wan J, et, al.Humanin Amaletsa Kuchepa kwa Chidziwitso Chokhudzana ndi Zaka mu Mbewa ndipo Zimagwirizanitsidwa ndi Kupititsa patsogolo Kuzindikira kwa Zaka mwa Anthu. Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7. PMID: 30242290; PMCID: PMC6154958.
[9] .Charununtakorn ST, Shinlapawittayatorn K, et, al.Potential Maudindo a Humanin pa Apoptosis mu Mtima. Cardiovasc Ther. 2016 Apr; 34 (2): 107-14. doi: 10.1111/1755-5922.12168. PMID: 26667157.