HUMANIN TRIFLUOROACETATE cas 330936-69-1    WHATSAPP:+86-19031013676

Humanin (HN) waa polypeptide mitochondrial gaaban oo dabiici ah oo leh saameyn antiapoptotic iyo neuroprotective.^[2]. Humanin waxay unugyada ka ilaalisaa cuduro kala duwan, oo ay ku jiraan cadaadiska oksaydhiyaha iyo cytotoxicity ee ay keento kicinta kala duwan^[3] oo leh dhaqdhaqaaq ballaadhan oo xagga xameetida, maskaxda, xiniinyaha, iyo wadnaha^[4]. Humanin iyo analogs-keeda ayaa loo isticmaali karaa bartilmaameedyo daweyn oo wanaagsan oo ka dhan ah cudurrada neuroprotective iyo neurodegenerative^[1].

Humanin waxay kordhisay jiritaanka unugga. HN waxay hoos u dhigtay boqolkiiba unugyada hypodiploid KGN iyo sidoo kale boqolkiiba unugyada KGN apoptotic. Humanin waxa loo tixgalin karaa in ay tahay arrin ka hortagta badbaadada ee xariiqda unugyada burooyinka^[5]. Humanin waxaa laga yaabaa inay ku lug yeelato jawaabta HLECs ee cadaadiska oksaydhka, iyo muujinta HN ayaa si weyn loo hagaajiyay xaaladaha walaaca oksaydhka. Intaa waxaa dheer, HN exogenous waxay hoos u dhigtay nuxurka ROS ee gudaha iyo dhaawaca mitochondrial, iyo kor u kaca biosynthesis mitochondrial; si kastaba ha ahaatee, ilaalintan ayaa ku luntay qaabka unugyada garaaca ee Humanin endogenous^[6]. Isdhexgalka Humanin iyo reseptors (CNTFR, WSX-1, iyo gp130) waxay dhaqaajin karaan dariiqa calaamadaynta STAT3 iyada oo loo marayo korodhka muujinta STAT3 sidaas awgeedna waxay horseedi kartaa korodhka badbaadada unugyada beta ee xameetida.^[9].

Maamulka Humanin wuxuu leeyahay saameyn neuroprotective in vitro ee moodooyinka dhaqanka unugga aadanaha waana ku filan yahay si loo hagaajiyo garashada gudaha vivo ee jiirarka da'da ah.^[8]. Si loo fahmo saamaynta Humanin ee shaqada maskaxda, Saamaynta S14G-HN ee diazepam (DZP) -dhimista xusuusta iyo walaaca jiirarka iyadoo la adeegsanayo tijaabada aqoonsiga shayga iyo tijaabada eber-maze. Cirbadeynta intraperitoneal ee S14G-HN waxay beddeshay xusuusta xusuusta ee DZP, halka aan isbeddel weyn lagu arag calaamadaha dabeecadda walaaca. S14G- Humanin wax saameyn ah kuma yeelan dhaqdhaqaaqa lugaha ee labada imtixaanba, taasoo muujineysa in S14G-HN aysan saameyn ku yeelan shaqada jirka ama dhiirigelinta.^[7].

Tixraacyo:
[1] Hazafa A, Batool A, iyo al. Humanin: peptide-ka-mitochondrial-ka-soo-baxa ee daaweynta cudurrada la xiriira apoptosis. Nolosha Sci. 2021 Jan 1;264:118679. doi: 10.1016/j.lfs.2020.118679. Epub 2020 Oct 29. PMID: 33130077.
[2]. Salemi M, Ridolfo F, et, al. Muujinta hiddaha aadanaha ee fibroblast ee maadooyinka Down syndrome-ka. Int J Med Sci. 2020 Jan 18;17(3):320-324. doi: 10.7150/ijms.39145. PMID: 32132866; PMCID: PMC7053358.
[3] Luciano F, Zhai D, et. J Biol Chem. 2005 Abriil 22;280 (16): 15825-35. doi: 10.1074/jbc.M413062200. Epub 2005 Jan 20. PMID: 15661735.
[4] Paharkova V, Alvarez G, iyo al. Jiirka Humanin waxaa lagu dhejiyay oo lagu turjumay mitochondria waxaana lagu meeleeyay qaybta mitochondrial halkaasoo ay maamusho wax soo saarka ROS. Mol Cell Endocrinol 2015 Seb 15;413:96-100. doi: 10.1016/j.mce.2015.06.015. Epub 2015 Jun 23. PMID: 26116236.
[5] Marvaldi C, Martin D, iyo al. Mitochondrial humanin peptide wuxuu u shaqeeyaa sidii arrin cytoprotective ah oo badbaadada unugyada granulosa. Taran. 2021 Abriil 20; 161 (5): 581-591. doi: 10.1530/REP-20-0197. PMID: 33764899.
[6] Yang H, Cui Y, et, al. Doorka cytoprotective ee humanin ee lens epithelial cell oxidative stress? dhaawac sababay. Mol Med Rep. 2020 Agoosto; 22 (2): 1467-1479. doi: 10.3892/mmr.2020.11202. Epub 2020 Jun 2. PMID: 32627019; PMCID: PMC7339735.
[7]. Murakami M, Nagahama M, et, al. Humanin waxay hagaajisaa xusuusta diazepam ay keentay jiirarka. Neuropeptides. 2017 Abril;62:65-70. doi: 10.1016/j.npep.2016.10.008. Epub 2016 Oct 29. PMID: 27814910.
[8] Yen K, Wan J, et, al.Humanin waxa uu ka hortagaa hoos u dhaca garaadka ee da'da la xidhiidha ee jiirarka waxana uu ku xidhan yahay da'da garashada ee bini'aadamka oo la hagaajiyay. Sci Rep. 2018 Seb 21; 8 (1): 14212. doi: 10.1038/s41598-018-32616-7. PMID: 30242290; PMCID: PMC6154958.
[9] .Charununtakorn ST, Shinlapawittayatorn K, et, al. Doorarka suurtagalka ah ee Humanin ee Apoptosis ee Wadnaha. Wadnaha Ther. 2016 Abriil; 34 (2): 107-14. doi: 10.1111/1755-5922.12168. PMID: 26667157.