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Iul. 12, 2023 09:51 Ad album

HUMANIN TRIFLUOROACETATE cas 330936-69-1 WHATSAPP:+86-19031013676



HUMANIN TRIFLUOROACETATE cas 330936-69-1    WHATSAPP:+86-19031013676

Humanin (HN) est brevis polypeptida mitochondrialis naturalis cum effectibus antipoptoticis et neuroprotectivo.[2]. Humanin cellulas contra varios morbos, inter accentus oxidative et cytotoxicitatem, variis stimulis inducta, tutantur[3] cum lato-spectro in pancreate, cerebro, testis et corde[4]. Humanin eiusque analogs uti possunt ut scuta therapeutica bona contra morbos neuroprotectivos et neurodegenerativos[1].

Humanin cellam augebat viability. HN decrevit recipis cellularum hypodiploidis KGN necnon cellularum apoptoticorum KGN recipis. Humanin considerari potuit elementum pro-supersestum in hac linea cellula tumore[5]. Humanin in responsione HLECs ad accentus oxidative implicari potest, et HN expressio sub condicionibus accentus oxidativa signanter orta est. Praeterea exogenous HN contentum intracellularem ROS et damnum mitochondriale imminutum, et biosynthesi mitochondriale auctum; attamen haec protectio in endogeno Humanin cellae cella exemplo amissa est[6]. Commercio Humanin et eius receptorum (CNTFR, WSX-1, gp130) potuit iter STAT3 signantem movere per augmentum expressionis STAT3 ac proinde ad augmentum betae cellae superstes in pancreate.[9].

Humanina administratio neuroprotectivos effectus habet in vitro in exemplaribus culturae cellae humanae et sufficit ad cognitionem vivorum in muribus senibus emendandis.[8]. Ut effectus Humanin in functione cerebri cognoscant, Effectus S14G-HN in diazepam (DZP) memoriam incommodi et anxietatem in muribus induxit utens cognitio obiecti probatio et nulla probatio erroris. Iniectio intraperitonealis S14G-HN invertitur DZP-inducta memoria defectus, cum nulla notabilis mutatio in se gerendi notis anxietatis observata est. S14G- Humanin in actu motorio nullum effectum habuit in utroque experimento, significans S14G-HN non affici physicam operationem vel motivum.[7].

Notae:
[1]. Hazafa A, Batool A, et, al. Humanin: Peptidium mitochondriale in curatione morborum apoptosis relatum. Vita sci. 2021 Ian 1, 264:118679. doi: 10.1016/j.lfs.2020.118679. Epub 2020 Oct 29. PMID: 33130077.
[2]. Salemi M, Ridolfo F, et, al.Humanin gene expressio in fibroblast de Duno syndrome subjecta. Int J Med Sci. 2020 Ian 18, 17 (3):320-324. doi: 10.7150/ijms.39145. PMID: 32132866; PMCID: PMC7053358.
[3]. Luciano F, Zhai D, et,al.Cytoprotective peptidium humaninum alligat et vetat proapoptoticum Bcl-2/Bax dapibus familiae BimEL. J Biol Chem. 2005 Apr. 22, 280 (16):15825-35. doi: 10.1074/jbc.M413062200. Epub 2005 Ian 20. PMID: 15661735.
[4]. Paharkova V, Alvarez G, et al. Rat Humanin in mitochondria encoded et transfertur et ad mitochondrialem cellulam collocatur ubi productionem ROS disponit. Mol Cell Endocrinol. 2015 Sep 15, 413:96-100. doi: 10.1016/j.mce.2015.06.015. Epub 2015 Iun 23. PMID: 26116236.
[5]. Marvaldi C, Martin D, et al. Peptidium mitochondriale humaninum agit ut factor cytoprotectivus in cellulis granulosis superstes. Reproduction. 2021 Apr 20, 161(5): 581-591. doi: 10.1530/REP-20-0197. PMID: 33764899.
[6]. Yang H, Cui Y, et, al. Cytoprotective munus humaninum in lens epithelial cellae oxidativae accentus? iniuriae adductus. Mol Med Rep. 2020 Aug;22(2):1467-1479. doi: 10.3892/mmr.2020.11202. Epub 2020 Iun 2. PMID: 32627019; PMCID: PMC7339735.
[7]. Murakami M, Nagahama M, et, al. Humanin meliorat diazepam-inducta memoria in muribus deficit. Neuropeptides. 2017 Apr;62:65-70. doi: 10.1016/j.npep.2016.10.008. Epub 2016 Oct 29. PMID: 27814910.
[8]. Yen K, Wan J, et, al.Humanin praecaventia aetatis Cognitivae declinationis in Muribus affinis et cum Aevo Cognitivo confirmato coniungitur in hominibus. Sci Rep. 2018 Sep 21, 8(1):14212. doi: 10.1038/s41598-018-32616-7. PMID: 30242290; PMCID: PMC6154958.
[9] .Charununtakorn ST, Shinlapawittayatorn K, et, al. Potentiales partes Humanin de Apoptosin in Cor. Cardiovasc, patris. 2016 Apr;34(2):107-14. doi: 10.1111/1755-5922.12168. PMID: 26667157.

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