HUMANIN TIFLUOROACETATE cas 330936-69-1    WHATSAPP:+86-19031013676

Humanin (HN) o se polypeptide mitochondrial faʻanatura faʻatasi ma aʻafiaga antiapoptotic ma neuroprotective^[2]. E puipuia e le Humanin sela mai faʻamaʻi eseese, e aofia ai le faʻamaʻi faʻamaʻi ma le cytotoxicity e faʻaosoina e ala eseese^[3] fa'atasi ai ma gaioiga lautele o alaleo ile pancreas, fai'ai, su'esu'e, ma le fatu^[4]. O le Humanin ma ana analog e mafai ona faʻaaogaina e avea ma faʻataʻitaʻiga lelei faʻasaga i faʻamaʻi neuroprotective ma neurodegenerative^[1].

Humanin fa'ateleina le olaola. O le HN na faʻaititia le pasene o sela KGN hypodiploid faʻapea foʻi ma le pasene o sela KGN apoptotic. E mafai ona manatu le Humanin o se mea e ola ai i lenei laina tumo^[5]. E ono aʻafia le Humanin i le tali atu a le HLEC i le faʻamaʻi faʻamaʻi, ma o le faʻaaliga o le HN na matua faʻamalosia i lalo o tulaga faʻamaʻi faʻamaʻi. E le gata i lea, o le exogenous HN na faʻaititia ai le intracellular ROS content ma le mitochondrial faʻaleagaina, ma faʻaleleia le biosynthesis mitochondrial; ae ui i lea, o lenei puipuiga na leiloa i le Humanin knockdown cell model^[6]. O fegalegaleaiga a le Humanin ma ona tali (CNTFR, WSX-1, ma le gp130) e mafai ona faʻagaoioia le ala faʻailoga STAT3 e ala i le faʻateleina o le STAT3 faʻamatalaga ma mafua ai ona faʻateleina le ola o le beta i le pancreas.^[9].

O le pulega a le Humanin o loʻo i ai aʻafiaga o le neuroprotective in vitro i faʻataʻitaʻiga aganuʻu a le tagata ma e lava e faʻaleleia ai le malamalama i vivo i isumu matutua.^[8]. Ina ia malamalama i aʻafiaga o le Humanin i le gaioiga o le faiʻai, O le aʻafiaga o le S14G-HN i luga o le diazepam (DZP) - faʻaleagaina le mafaufau ma le popole i isumu e faʻaaoga ai le suʻega o mea faitino ma le zero-maze test. Intraperitoneal tui ole S14G-HN na suia ai le DZP-induced memory deficit, ae leai se suiga taua na matauina i faailoga o le popole. S14G- Humanin e leai se aʻafiaga i gaioiga o locomotor i suʻega uma, e faʻaalia ai o le S14G-HN e leʻi aʻafia ai le gaioiga faaletino poʻo le faʻaosofia.^[7].

Fa'asinomaga:
[1]. Hazafa A, Batool A, et,al. Humanin: O se peptide e maua mai i le mitochondrial i le togafitiga o faʻamaʻi faʻamaʻi apoptosis. Life Sci. 2021 Ian 1;264:118679. doi: 10.1016/j.lfs.2020.118679. Epub 2020 Oketopa 29. PMID: 33130077.
[2]. Salemi M, Ridolfo F, et, al.Humanin gene expression i fibroblast o mataupu Down syndrome. Int J Med Sci. 2020 Ian 18;17(3):320-324. doi: 10.7150/ijms.39145. PMID: 32132866; PMCID: PMC7053358.
[3]. Luciano F, Zhai D, et, al.Cytoprotective peptide humanin fusifusia ma taofia proapoptotic Bcl-2 / Bax aiga protein BimEL. J Biol Chem. 2005 Apr 22;280(16):15825-35. doi: 10.1074/jbc.M413062200. Epub 2005 Ian 20. PMID: 15661735.
[4]. Paharkova V, Alvarez G, ma, al. Rat Humanin o loʻo faʻapipiʻiina ma faʻaliliu i le mitochondria ma o loʻo faʻaogaina i le vaega mitochondrial lea e faʻatonutonu ai le gaosiga o le ROS. Mol Cell Endocrinol. 2015 Sep 15;413:96-100. doi: 10.1016/j.mce.2015.06.015. Epub 2015 Iuni 23. PMID: 26116236.
[5]. Marvaldi C, Martin D, et,al. Mitochondrial humanin peptide e galue o se cytoprotective factor i le ola o le cell granulosa. Toe gaosia. 2021 Aperila 20;161(5):581-591. doi: 10.1530/REP-20-0197. PMID: 33764899.
[6]. Yang H, Cui Y, et, al.Cytoprotective matafaioi a humanin i tioata epithelial cell oxidative stress?manuʻa faʻaoso. Mol Med Rep. 2020 Aukuso;22(2):1467-1479. doi: 10.3892/mmr.2020.11202. Epub 2020 Iuni 2. PMID: 32627019; PMCID: PMC7339735.
[7]. Murakami M, Nagahama M, et,al. E fa'aleleia e le Humanin le fa'aletonu o mafaufauga e mafua mai i le diazepam i isumu. Neuropeptides. 2017 Ape;62:65-70. doi: 10.1016/j.npep.2016.10.008. Epub 2016 Oketopa 29. PMID: 27814910.
[8]. Yen K, Wan J, et,al.Humanin e Puipuia le Pa'u o le Gagana Fa'ata'ita'i i Vaitausaga i isumu ma Fa'atasi ma le Fa'aleleia o le Tausaga Fa'atonu i Tagata. Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7. PMID: 30242290; PMCID: PMC6154958.
[9] .Charununtakorn ST, Shinlapawittayatorn K, et, al. Matafaioi a le Humanin i Apoptosis i le Loto. Cardiovasc Ther. 2016 Ape;34(2):107-14. doi: 10.1111/1755-5922.12168. PMID: 26667157.